Coagulation and Hemostasis in Cardiac Surgery

Current

• Characterization of the duration of the action of clopidogrel in healthy volunteers
• Evaluation of the potential to manipulate platelet function in patients on clopidogrel
• Evaluation of point-of-care tests of platelet function to guide perioperative transfusion of blood and blood products in the setting of cardiac surgery with cardiopulmonary bypass

Completed

• Evaluation of the Ultegra®, point-of-care platelet function instrument during cardiac surgery
• Evaluation of reopro thromboelastography during cardiopulmonary bypass.
• Evaluation of the high dose thrombin time to measure heparin anticoagulation during cardiac surgery.
• Evaluation of the Rapid Point® point-of-care platelet function analyzer during cardiac surgery
• Comparison of the potential of standard platelet aggregometry and three different point-of-care platelet function analyzers to detect the defect of clopidogrel in healthy volunteers.