Recognition and Publications

Filizola M, Devi LA. Structural biology: How opioid drugs bind to receptors. Nature. 2012 May 16;485(7398):314-7.

Costantino CM, Gomes I, Stockton SD, Lim MP, Devi LA. Opioid receptor heteromers in analgesia. Expert Rev Mol Med. 2012 Apr 10;14:e9.

Costantino CM, Gupta A, Yewdall AW, Dale BM, Devi LA, Chen BK. Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4 T Cells. PLoS One. 2012;7(3): e33961.

Rozenfeld R, Bushlin I, Gomes I, Tzavaras N, Gupta A, Neves S, Battini L, Gusella GL, Lachmann A, Ma'ayan A, Blitzer RD, Devi LA. Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. PLoS One. 2012;7(1):e29239.

Abul-Husn NS, Annangudi SP, Ma'ayan A, Ramos-Ortolaza DL, Stockton SD Jr, Gomes I, Sweedler JV, Devi LA. Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. PLoS One. 2011;6(10):e25535.

Miller LK, Hou X, Rodriguiz RM, Gagnidze K, Sweedler JV, Wetsel WC, Devi LA. Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. J Neurochem. 2011 Oct 4.

Gupta A, Devi LA, Gomes I. Potentiation of μ-opioid receptor-mediated signaling by ketamine. J Neurochem. 2011 Oct;119(2):294-302.

Miller LK, Devi LA. The highs and lows of cannabinoid receptor expression in disease: mechanisms and their therapeutic implications. Pharmacol Rev. 2011 Sep;63(3):461-70.

Imai S, Sudo Y, Nakamura A, Ozeki A, Asato M, Hojo M, Devi LA, Kuzumaki N, Suzuki T, Uezono Y, Narita M. Possible involvement of β-endorphin in a loss of the coordinated balance of μ-opioid receptors trafficking processes by fentanyl. Synapse. 2011 Sep;65(9):962-6.

Narita M, Imai S, Nakamura A, Ozeki A, Asato M, Rahmadi M, Sudo Y, Hojo M, Uezono Y, Devi LA, Kuzumaki N, Suzuki T. Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state. Addict Biol. 2011 Aug 4.

Lim MP, Devi LA, Rozenfeld R. Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis. Cell Death Dis. 2011 Jun 9;2:e170.

Gomes I, Ijzerman AP, Ye K, Maillet EL, Devi LA. G protein-coupled receptor heterodimerization: a role in allosteric modulation of ligand binding. Mol Pharmacol. 2011 Jun;79(6):1044-52.

Rozenfeld R, Gupta A, Gagnidze K, Lim MP, Gomes I, Lee-Ramos D, Nieto N, Devi LA. AT1R-CB(1)R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J. 2011 May 3;30(12):2350-63.

Golebiewska U, Johnston JM, Devi L, Filizola M, Scarlata S. Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptors. Biochemistry. 2011 Apr 12;50(14):2829-37.

Rozenfeld R, Devi LA. Exploring a role for heteromerization in GPCR signalling specificity. Biochem J. 2011 Jan 1;433(1):11-8.

Gomes I, Dale CS, Casten K, Geigner MA, Gozzo FC, Ferro ES, Heimann AS, Devi LA. Hemoglobin-derived peptides as novel type of bioactive signaling molecules. AAPS J. 2010 Dec;12(4):658-69.

Ouimet T, Orng SV, Poras H, Gagnidze K, Devi LA, Fournie-Zaluski MC, Roques BP. Identification of an endothelin-converting enzyme-2 specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay. J Biol Chem. 2010 Nov 5;285(45):34390-400.

Larocca TJ, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, Alvin Z, Champion HC, Haddad G, Hajjar RJ, Devi LA, Schecter AD, Tarzami ST. [beta2]-adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4. J Cardiovasc Pharmacol. 2010 Nov;56(5):548-59.

Williams D, Devi LA. Escorts take the lead: Molecular chaperones as therapeutic targets. Prog Mol Biol Transl Sci. 2010;91C:121-149.

Hipser C, Bushlin I, Gupta A, Gomes I, Devi LA. Role of antibodies in developing drugs that target G-protein-coupled receptor dimers. Mt Sinai J Med. 2010 Jul-Aug;77(4):374-80.

Gupta A, Mulder J, Gomes I, Rozenfeld R, Bushlin I, Ong E, Lim M, Maillet E, Junek M, Cahill CM, Harkany T, Devi LA. Increased abundance of opioid receptor heteromers after chronic morphine administration.Sci Signal. 2010 Jul 20;3(131):ra54.  
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Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: The G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15;26(14):1804-5.

Morgan DJ, Wei S, Gomes I, Czyzyk T, Mzhavia N, Pan H, Devi LA, Fricker LD, Pintar JE. The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J Neurochem. 2010 J Neurochem. 2010 Jun 1;113(5):1275-84.

Rozenfeld R, Devi LA. Receptor heteromerization and drug discovery. Trends Pharmacol Sci. 2010 Mar;31(3):124-30.

Ramos-Ortolaza DL, Bushlin I, Abul-Husn N, Annangudi SP, Sweedler J, Devi LA. Quantitative neuroproteomics of the synapse. Methods Mol Biol. 2010;615:227-46.

Morón JA, Gullapalli S, Taylor C, Gupta A, Gomes I, Devi LA. Modulation of opiate-related signaling molecules in morphine-dependent conditioned behavior: conditioned place preference to morphine induces CREB phosphorylation. Neuropsychopharmacology. 2010 Mar;35(4):955-66.

Miller J, Agarwal A, Devi LA, Fontanini K, Hamilton JA, Pin JP, Shields DC, Spek CA, Sakmar TP, Kuliopulos A, Hunt SW 3rd. Insider access: pepducin symposium explores a new approach to GPCR modulation. Ann N Y Acad Sci. 2009 Nov;1180 Suppl 1:E1-12.

Bushlin I, Rozenfeld R, Devi LA. Cannabinoid-opioid interactions during neuropathic pain and analgesia. Curr Opin Pharmacol. 2010 Feb;10(1):80-6.

Abul-Husn N, Bushlin I, Morón JA, Jenkins SL, Dolios G, Wang R, Iyengar R, Ma'ayan A. and Devi LA. Systems approach to explore components and interactions in the presynapse. Proteomics. 2009 Jun 27;9(12):3003-3315

Ferre, S, Baler, ., Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin J-P, Volkow ND, Waldohoer M, Woods AS, and Franco R. Building a new conceptual framework fo receptor heteromers. Nature Chem. Biol. 2009; 5:131-134

Ellgren M, Artmann A, Tkalych O, Gupta A, Hansen HS, Hansen SH, Devi LA, Hurd YL. Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. Eur Neuropsychopharmacol. 2008 Nov;18(11):826-34

Decaillot FM, Rozenfeld R, Gupta A, and Devi LA. Cell Surface Targeting of mu-delta Opioid Receptor Heterodimers by RTP4. Proc. Natl. Acad. Sci. USA, 2008;105:16045-50.

Gagnidze K, Sachchidanand, Rozenfeld R, Mezei M, Zhou MM, Devi LA. Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem. 2008 Jun 26;51(12):3378-87.

Charlton JJ, Allen PB, Psifogeorgou K, Chakravarty S, Gomes I, Neve RL, Devi LA, Greengard P, Nestler EJ, Zachariou V. Multiple actions of spinophilin regulate mu opioid receptor function. Neuron. 2008 Apr 24;58(2):238-47.

Jenkins SL, Iyengar R, Diverse-Pierluissi MA, Chan AM, Devi LA, Sobie EA, Ting AT, Weinstein DC. Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment. Sci Signal. 2008;1(9):tr2.

Iyengar R, Diverse-Pierluissi MA, Jenkins SL, Chan AM, Devi LA, Sobie EA, Ting AT, Weinstein DC. Inquiry learning. Integrating content detail and critical reasoning by peer review. Science. 2008 Feb 29;319(5867):1189-90.

Gupta A, Rozenfeld R, Gomes I, Raehal KM, Décaillot FM, Bohn LM, Devi LA. Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies. J Biol Chem. 2008 Apr 18;283(16):10735-44.

Heimann AS, Gomes I, Dale CS, Pagano RL, Gupta A, de Souza LL, Luchessi AD, Castro LM, Giorgi R, Rioli V, Ferro ES, Devi LA. Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20588-93.

Rozenfeld R, Abul-Husn NS, Gomez I, Devi LA. An emerging role for the delta opioid receptor in the regulation of mu opioid receptor function. ScientificWorldJournal. 2007 Nov 2;7:64-73. Review.

Morón JA, Devi LA. Use of proteomics for the identification of novel drug targets in brain diseases. J Neurochem. 2007 Jul;102(2):306-15.

Rozenfeld R, Devi LA. Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. FASEB J. 2007 Aug;21(10):2455-65.

Bolan EA, Kivell B, Jaligam V, Oz M, Jayanthi LD, Han Y, Sen N, Urizar E, Gomes I, Devi LA, Ramamoorthy S, Javitch JA, Zapata A, Shippenberg TS. D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism. Mol Pharmacol. 2007 May;71(5):1222-32.

Harkany T, Guzmán M, Galve-Roperh I, Berghuis P, Devi LA, Mackie K. The emerging functions of endocannabinoid signaling during CNS development. Trends Pharmacol Sci. 2007 Feb;28(2):83-92.

Gupta A, Décaillot FM, Gomes I, Tkalych O, Heimann AS, Ferro ES, Devi LA. Conformation state-sensitive antibodies to G-protein-coupled receptors. J Biol Chem. 2007 Feb 23;282(8):5116-24.

Gendron L, Esdaile MJ, Mennicken F, Pan H, O'Donnell D, Vincent JP, Devi LA, Cahill CM, Stroh T, Beaudet A. Morphine priming in rats with chronic inflammation reveals a dichotomy between antihyperalgesic and antinociceptive properties of deltorphin. Neuroscience. 2007 Jan 5;144(1):263-74.

Morón JA, Abul-Husn NS, Rozenfeld R, Dolios G, Wang R, Devi LA. Morphine administration alters the profile of hippocampal postsynaptic density-associated proteins: a proteomics study focusing on endocytic proteins. Mol Cell Proteomics. 2007 Jan;6(1):29-42.

Gupta A, Devi LA. The use of receptor-specific antibodies to study G-protein-coupled receptors. Mt Sinai J Med. 2006 Jul;73 (4):673-81.

Decaillot FM, Che FY, Fricker LD, Devi LA. Peptidomics of Cpefat/fat mouse hypothalamus and striatum: effect of chronic morphine administration. J Mol Neurosci. 2006;28(3):277-84.

Gupta A, Decaillot FM, Devi LA. Targeting opioid receptor heterodimers: strategies for screening and drug development. AAPS J. 2006 Mar 10;8(1):E153-9.

Pignatari GC, Rozenfeld R, Ferro ES, Oliveira L, Paiva AC, Devi LA. A role for transmembrane domains V and VI in ligand binding and maturation of the angiotensin II AT1 receptor. Biol Chem. 2006 Mar;387(3):269-76.

He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA, Iyengar R. The G{alpha}o/i-coupled Cannabinoid Receptor-mediated Neurite Outgrowth Involves Rap Regulation of Src and Stat3. J Biol Chem. 2005 Sep 30; 280(39):33426-34.

Fricker AD, Rios C, Devi LA, Gomes I. Serotonin receptor activation leads to neurite outgrowth and neuronal survival. Brain Res Mol Brain Res. 2005 Aug 18; 138(2):228-35.

Pan H, Nanno D, Che FY, Zhu X, Salton SR, Steiner DF, Fricker LD, Devi LA . Neuropeptide processing profile in mice lacking prohormone convertase-1. Biochemistry. 2005 Mar 29; 44(12):4939-48.

Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor induced neurite outgrowth is mediated by Rap1 activation through Galphao/I-triggered proteasomal degradation of Rap1GAPIL. J Biol Chem 2005 Mar 25;280(12):11413-21.

Taylor C, Fricker AD, Devi LA, Gomes I. Mechanisms of action of antidepressants: from neurotransmitter systems to signaling pathways. Cell Signal 2005 May; 17(5):549-57.

Gomes I, Gupta A, Filipovska J, Szeto HH, Pintar JE, Devi LA. A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia Proc Natl Acad Sci. 2004; 101:5135-5139.

Jordan BA, Gomes I, Rios C, Filipovska J, Devi LA. Functional interactions between mu opioid and alpha 2A-adrenergic receptors. Mol Pharmacol. 2003; 64:1317-1324.

Gomes I, Filipovska J, Devi LA. Opioid receptor oligomerization. Detection and functional characterization of interacting receptors. Methods Mol Med. 2003;84:157-83.

Mzhavia N, Pan H, Che FY, Fricker LD, Devi LA . Characterization of endothelin-converting enzyme-2. Implication for a role in the nonclassical processing of regulatory peptides. J Biol Chem. 2003 Apr 25;278(17):14704-11.

Gomes I, Filipovska J, Jordan B, Devi LA. Oligomerization of opioid receptors. Methods 2002 Aug;27(4):358-65.

Mzhavia N, Qian Y, Feng Y, Che FY, Devi LA, Fricker LD. Processing of proSAAS in neuroendocrine cell lines. Biochem J. 2002;361:67-76.

Jordan BA, Trapaidze N, Gomes I, Nivarthi R, Devi LA. Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci. 2001;98:343-348.

Mzhavia N, Qian Y, Feng Y, Che FY, Devi LA, Fricker LD. Processing of proSAAS in neuroendocrine cell lines. Biochem J. 2002;361:67-76.

Devi LA. Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. TIPS 2001;22:532-537.

Berman Y, Mzhavia N, Polonskaia A, Devi LA. Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice. J Biol Chem. 2001;276:1466-1473.

Che FY, Yan L, Li H, Mzhavia N, Devi LA, Fricker LD. Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice. Proc Natl Acad Sci. 2001;9:9971-9976.

Mzhavia M, Berman Y, Che FY, Fricker LD, Devi LA. ProSAAS processing in mouse brain and pituitary. J Biol Chem 2001;276:6207-6213.

Gomes I, Jordan BA, Nagy V, Trapaidze N, Gupta A, Devi LA. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. J Neurosci 2000;20:RC110.

Fricker LD, McKinzie AA, Sun J, Curran E, Qian Y, Yan L, Patterson SD, Courchesne PL, Richards B, Levin N, Mzhavia N, Devi LA, Douglass J. Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci 2000;20:639-648.

Jordan BA, Devi LA. G-protein-coupled receptor heterodimerization modulates receptor function. Nature 1999;5:697-700.


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Lakshmi A. Devi, PhD
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