About the Jabs Laboratory
Birth defects occur in approximately five percent of newborns, and there are more than 700 inherited conditions with craniofacial abnormalities. Here at the Jabs Laboratory we focus our research on raising our understanding of the molecular basis of human malformation disorders including craniosynostosis, oral clefting, limb disorders and syndromes:
- Treacher Collins
Mutations for syndromic craniosynostosis, cleft lip and palate, and mandibulofacial dysostosis conditions were identified in homeobox and helix-loop-helix transcription factors, growth factor receptors, connexins, and cohesion proteins.