P450-CYP2C19

Test Description:
The cytochrome P450 2C family is responsible for metabolizing a variety of exogenous and endogenous substrates. The human cytochrome P450-2C19 gene spans a region of approximately 56 kilobases and is composed of nine exons. The gene resides on chromosome 10 (q24) and is clustered among other closely related 2C genes in the order: Cen-2C18-2C19-2C9-2C8-Tel2. The 2C19 variant nomenclature adopted follows that outlined by the Human Cytochrome P450 (CYP) Allele Nomenclature Committee. Variants are accordingly classified as *2 to *12. This tests screens for the seven most common variants seen across various ethnic groups (2C19*2 – 2C19*8).

References:
1. http://www.ensembl.org/Homo_sapiens/exonview?transcript=ENST00000285981&db=core
2. Gray IC, Nobile C, Muresu R, Ford S, Spurr NK. 1995. A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics. 28:328-332.
3. http://www.imm.ki.se/CYPalleles/

Specimen Requirements:
Two 5-10 ml tubes of anticoagulated blood. The preferred anticoagulant is EDTA (lavendar top tubes), ACD (yellow top) tubes are also accepted.

Shipping: Send at room temperature.

Turnaround Time: 7-10 days

CPT Codes: 83891, 83900, 83901x3, 83914x3, 83912

Consent Form: Pharmacogenic Testing Consent [PDF]

Requisition Form: General Test Requisition [PDF]