Recognition and Publications

Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Wang J, Li X, Dietz DM, Pan N, Vialou VF, Neve RL, Yue Z, Han MH. Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science, 344(6181):313-9, 2014.

Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. G9a influences neuronal subtype specification in striatum. Nature Neuroscience, 2014 Mar. [PubMed]

Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison M, Ferguson D, Golden SA, Koo JW, Chaudhury D, Christoffel DJ, Pomeranz L, Friedman JM, Russo SJ, Nestler EJ, Han MH. Stress and CRF gate neural activation of BDNF in the mesolimibic reward pathway. Nature Neuroscience, 2014 Jan;17(1):27-9. [PubMed]

Lobo MK, Zaman S, Damez-Werno D, Koo JW, Bagot R, DiNieri J, Nugent A, Finkel E, Chaudhury D, Chandra R, Riberio E, Rabkin J, Mouzon E, Cachope R, Cheer J, Han MH, Dietz D, Self D, Hurd Y, Vialou V, Nestler EJ. DeltaFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. Journal of Neuroscience 2013 Nov 20;33(47):18381-95. [PubMed]

Chandra R, Lenz JD, Gancarz AM, Chaudhury D, Schroeder GL, Han MH, Cheer J, Dietz DM, Lobo MK. Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. Frontiers in Molecular Neuroscience 2013 May 24;6:13. [PubMed]

Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN,  Nestler EJ. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nature Neuroscience 2013 Apr;16(4):434-40. [PubMed]

Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel D, Nectow AR, Ekstrand M, Domingos A, Mazie-Robison M, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH. Rapid regulation of depression-like behaviors by control of midbrain dopamine neurons. Nature 2013 Jan 24;493(7433):532-6. [Chaudhury and Walsh contributed equally] [PubMed]

Russo SJ, Murrough JW, Han MH, Charney DS, Nestler EJ. Neurobiology of resilience. Nature Neuroscience 2012 Nov;15(11):1475-84. [PubMed]

Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han MH, Nestler EJ. BDNF is a negative modulator of morphine action. Science 2012 Oct 5;338(6103):124-8. [PubMed]

Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks A, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nature Neuroscience 2012 Sep;15(9):1245-54. [PubMed]

Han MH, Friedman AK. Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders. Neuropharmacology 2012 Jan;62(1):89-100. [PubMed]

Mazei-Robison MS, Koo JW, Friedman AK, Lansink CS, Robison AJ, Vinish M, Krishnan V, Kim S, Siuta MA, Galli MA, Niswender KD, Appasani R, Horvath MC, Neve RL, Worley PF, Snyder SH, Hurd YL, Cheer JF, Han MH, Russo SJ, Nestler EJ. Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron 2011 Dec 22;72(6):977-90. [PubMed]

Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA. Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania. Neuropsychopharmacology 2011 Jun;36(7):1478-88. [PubMed]

Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW. Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. Journal of Neuroscience 2011 May 25;31(21):7927-37. [PubMed]

Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greeengard P, Kim Y, Morrison JH, Russo SJ. IkappaB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. Journal of Neuroscience 2011 Jan 5;31(1):314-21. [PubMed]

Cao JL, Covington III HE, Friedman AK, Wilkinson MB, Walsh JJ, Cooper DC, Nestler EJ, Han MH. Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. Journal of Neuroscience 2010 Dec 8;30(49):16453-8. [PubMed]

Lobo MK, Covington III HE, Chaudhury D, Friedman AK, Sun HS, Damez-Werno D, Dietz D, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ. Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 2010 Oct 15;330(6002):385-90. [PubMed]

Cao JL, Vialou VF, Lobo MK, Robison AJ, Neve RL, Cooper DC, Nestler EJ, Han MH. Essential role of the cAMP-CREB pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons. Proc Natl Acad Sci USA 2010 Sep 28;107(39):17011-6. [PubMed]

Iñiguez SD, Vialou V, Warren BL, Cao JL, Alcantara LF, Davis LC, Manojlovic Z, Neve RL, Russo SJ, Han MH, Nestler EJ, Bolaños-Guzmán CA. Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress. Journal of Neuroscience 2010 Jun 2;30(22):7652-63. [PubMed]

Han MH, Renthal W, Ring RH, Rahman Z, Psifogeorgou K, Howland D, Birnbaum S, Young K, Neve R, Gomes I, Devi LA, Nestler EJ, Zachariou V. Brain region specific actions of RGS4 oppose morphine reward and dependence but promote analgesia. Biological Psychiatry 2010 Apr 15;67(8):761-9. [PubMed]

Wallace DL, Han MH, Graham DL, Green TA, Vialou VF, Iniguez SD, Cao JL, Chakravarty S, Kumar A, Krishnan V, Neve RL, Cooper DC, Bolanos CA, Barrot M, McClung CA, Nestler EJ. CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nature Neuroscience 2009 Feb;12(2):200-9. [Wallace and Han contributed equally] [PubMed]

Krishnan V, Han MH, Mazei-Robison M, Iñiguez SD, Ables JL, Vialou VF, Berton O, Ghose S, Covington HE 3rd, Wiley MD, Henderson RP, Neve RL, Eisch AJ, Tamminga CA, Russo SJ, Bolaños CA, Nestler EJ. AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biological Psychiatry 2008 Oct 15;64(8):691-700. [PubMed]

Huang YH, Lin Y, Brown TE, Han MH, Saal DB, Neve RL, Zukin RZ, Sorg BA, Nestler EJ, Malenka RC, Dong Y. CREB modulates the upstate of nucleus accumbens neurons: A critical role of synaptic NMDA receptors. Journal of Biological Chemistry 2008 Feb 1;283(5):2751-60. [PubMed]

Krishnan V, Han MH, Graham DL, Berton O, Renthal W, LaPlant Q, Graham A, Russo SJ, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Eisch AJ, Self DW, Lee FS, Tamminga C, Cooper DC, Gershenfeld HK, Nestler EJ. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 2007 Oct 19;131(2):391-404. [Krishnan and Han contributed equally] [PubMed]

Han MH, Bolanos CA, Green TA, Olson VG, Neve RL, Liu RJ, Aghananian GK, Nestler EJ. Role of cAMP response element-binding protein (CREB) in the rat locus coeruleus. Regulation of neuronal activity and opiate withdrawal behaviors. Journal of Neuroscience 2006 Apr 26;26(17):4624-9.[PubMed]

Contact Us

Ming-Hu Han, PhD
Tel: 212-659-1729
Fax: 212-831-0114

Icahn Medical Institute
Floor 12 Room 12-75B (Office)
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New York, NY 10029

Resilience Study News

Jump-starting natural resilience reverses stress susceptibility
NIH press release

Triggering resilience to depression
The Scientist press release

To quash depression, some brain cells must push through the stress
LA Times article

Stress: Brain yields clues about why some succumb while others prevail
NIMH press release

How mice cope with stressful social situations [PDF]
Preview in Cell

Resisting stress [PDF]
Research highlights in Nature Review Neuroscience

Active resilience [PDF]
Research highlights in Nature