Recognition and Publications

1. RONDEAU E, OCHI S, LACAVE R, HE CJ, MEDCALF R, DELARUE F, SRAER JD. Urokinase synthesis and binding by glomerular epithelial cells in culture. Kidney Int., 1989, 36:593-600.
   
   
2. VILLAMEDIANA LM, RONDEAU E, HE CJ, MEDCALF RL, PE
   
   
3. RALDI MN, LACAVE R, DELARUE F, SRAER JD. Thrombin regulates fibrinolytic components of human mesangial cells. Kidney Int., 1990, 38:956-961.HE CJ, RONDEAU E, MEDCALF RL, LACAVE R, SCHLEUNING WD, SRAER JD. Thrombin increases proliferation and decreases fibrinolytic activity of cultured glomerular epithelial cells. J. Cell. Physiol., 1991, 146:131-141.
   
   
4. HE CJ, REBIBOU JM, PERALDI MN, MEULDERS Q, RONDEAU E. Growth factor-like effect of urokinase type plasminogen activitor in human renal cells. Biochem. Biophys. Res. Commun., 1991, 176:1408-1416.
   
   
5. REBIBOU JM, HE CJ, MEULDERS Q, DELARUE F, RONDEAU E, SRAER JD. Characterization and localization of endothelin 1 (ET-1) receptors in human glomeruli. Nephrol. Dial. Transplant., 1992, 7:288-292.
   
   
6. HE CJ, KANFER A. Quantification and modulation of thrombomodulin activity in rat and human isolated glomeruli. Kidney Int., 1992, 41:1170-1174.
   
   
7. HE CJ, RONDEAU E, PERALDI MN, SRAER JD. Thrombin transduction pathways in human glomerular epithelial cells. J. Cell. Physiol. 1992, 150:475-483.
   
   
8. MEULDERS Q, HE CJ, ADIDA C, PERALDI MN, SCHLEUNING WD, SRAER JD. Tumor necrosis factor- increases antifibrinolytic activity of human mesangial cells. Kidney Int., 1992, 42:327-334.
   
   
9. HE CJ, NGUYEN G, LI XM, PERALDI MN, ADIDA C, RONDEAU E, SRAER JD. Transcriptional activation of the urokinase receptor gene by endothelin-1. Biochem. Biophys. Res. Commun. 1992, 186:1631-1638.
   
   
10. ELLIOT SJ, STRIKER LJ, HATTORI M, YANG CW, HE CJ, PETEN EP, STRIKER GE. Mesangial cells from diabetic NOD mice constitutively secrete increased amounts of insulin-like growth factor-1. Endocrinology. 1993, 133:1783-1788.
    
    
11. ZACHARIAS U, HE CJ, NGUYEN G, SRAER JD, RONDEAU E. Long-term effects of thrombin require sustained activation of the functional thrombin receptor. FEBS Lett. 1993, 334:225-228.
    
    
12. YANG CW, VLASSARA H, PETEN EP, HE CJ, STRIKER GE, STRIKER LJ. Upregulation of glomerular gene expression in diabetes: Role of advanced glycosylation endproducts. Proc. Natl. Acad. Sci. USA, 1994, 91:9436-9440.
    
    
13. BECQUEMONT L, NGUYEN G, PERALDI MN, HE CJ, SRAER JD, AND RONDEAU E. Expression of plasminogen/plasmin receptors on human glomerular epithelial cells. Am. J. Physiol. 1994, 36: F303-F310.
    
    
14. BAUDEAU C, DELARUE F, HE CJ, NGUYEN G, SRAER JD, AND RONDEAU E. Induction of MHC class II molecules HLA-DR, DP, and DQ and ICAM 1 in human podocytes by gamma-interferon. Exp. Nephrol. 1994, 2(5): 306-312.
    
    
15. YANG CW, HATTORI M, VLASSARA H, HE CJ, CAROME MA, YAMATO E, ELLIOT S, STRIKER GE, STRIKER LJ. Overexpression of TGF-b1 mRNA is associated with upregulation of glomerular tenascin and laminin gene expression in diabetic NOD mice. J. Am. Soc. Nephrol., 1995, 5:1610-1617.
    
    
16. XU YC, ZACHARIAS U, PERALDI MN, HE CJ, LU CY, SRAER JD, and RONDEAU E. Constitutive expression and modulation of the functional thrombin receptor in the human kidney. Am. J. Pathol., 1995, 146:101-110.
    
    
17. ZACHARIAS U, HE CJ, HAGEGE J XU Y, JD SRAER, and RONDEAU E. Thrombin and phorbol ester induce internalization of thrombin receptor of human mesangial cells through different pathways. Exp. Cell Res., 1995, 216 (2): 371-379.
    
    
18. HE CJ, STRIKER LJ, TSOKOS M, YANG CW, PETEN EP, STRIKER GE. Relationships between mesangial cell proliferation and types I and IV collagen mRNA levels in vitro. Am. J. Physiol., 1995, 269: C554-C562.
    
    
19. HE CJ, STRIKER LJ, ZALUT P, YANG CW, STRIKER GE. Molecular analysis of spontaneous glomerulosclerosis in Os/+ mice, a model with reduced nephron mass. Am. J. Physiol. 1995, 269:F266-273.
    
    
20. Striker GE, HE CJ, LIU ZH, YANG CW, ZALUPS RK, ESPOSITO C, and STRIKER LJ. Pathogenesis of non-immune glomerulosclerosis, studies in animals and potential applications to man. Lab. Invest., 1995, 73:596-605.
    
    
21. KANFER A, BRUCH JF, NGUYEN G, HE CJ, DELARUE F, FLAHAULT, NESSMANN C, AND UZAN S. Increased placental antifibrinolytic potential and fibrin deposits in pregnancy-induced hypertension and preeclampsia. Lab. Invest. 1996, 74:253-358.
    
    
22. HE CJ, ESPOSITO C, PHILLIPS C, ZALUPS RK, HENDERSON DA, STRIKER GE, AND STRIKER LJ. Dissociation of glomerulosclerosis, glomerular hypertrophy and cell proliferation in mouse srains heterozygous for a mutation (Os) which induces a 50% reduction in nephron number. J. Clin. Invest. 1996, 97:1242-1249.
    
    
23. YONG ML, WOJCIEHOWICZ D, MITSUHASHI T, GILMORE R, SHIMIZU N, LI J, STITT A, HE CJ, AND VLASSARA H. Molecular identity and tissue distribution of advanced glycation endproduct receptors. Proc. Natl. Acad. Sci. USA. 1996, 93:11047-11052.
    
    
24. KOSCHINSKY T, HE CJ, MITSUHASHI T, LIU C, BUENTING C, HEITMANN K, AND VLASSARA H. Reactive Advanced Glycation Endproducts from food: a new risk for diabetic complications. Proc. Natl. Acad. Sci. U.S.A., 1997, 94:6474-6479.
    
    
25. STITT AW, HE CJ, FRIEDMAN S, ROSSI P, SHER L, ONG L, FOUNDS H, LI YM, BUCALA R, AND VLASSARA H. Elevated serum AGE-modified ApoB in euglycemic, normolipidemic patients with atherosclerosis. Mol Medicine, 1997, 3:617-627.
    
    
26. ESPOSITO C ; HE CJ, ; STRIKER GE ; ZALUPS RK, AND STRIKER LJ: Nature and severity of the glomerular response to nephron reduction is strain-dependent in mice. Am J Pathol, 1999; 154:891-897.
    
    
27. RONDEAU E, SRAER JD; NGUYEN G, HE CJ; ZACHARIAS U and XU Y: Role of thrombin and its receptor, the protease-activated receptor 1, in the pathophysiology of glomerular injury. Adv Nephrol Necker Hosp; 1999, 29:17-34.
    
    
28. HE CJ, SABOL J, MITSUHASHI T AND VLASSARA H.: Dietary glycotoxins: Inhibition of reactive products by aminoguanidin facilitates renal clearance and reduce tissue sequestration. Diabetes; 1999, 48:1308-1315.
    
    
29. STITT AW, HE CJ, AND VLASSARA H. Characterization of the advanced glycation endproduct (AGE)-receptor complex in human vascular endothelial cells. Biochem. Biophys. Res. Commun. 1999, 256:549-556.
    
    
30. HE CJ, Zheng F, Stitt A, STRIKER LJ, HATTORI M, AND VLASSARA H. Differential expression of renal AGE-receptor genes in NOD mice: Possible role in nonobese diabetic renal disease. Kidney Int., 2000, 58:1931-1940.
    
    
31. HE CJ, KOSCHINSKY T, SABOL J, BUENTING C, HEITMANN K, AND VLASSARA H. Low expression of AGE-receptor-1 in peripheral blood mononuclear cells of diabetic patients. Mol. Medicine, 2001, 7(3): 159-68.
    
    
32. HE C, Charoenkul V, Kahn T, Langhoff E, Uribarri J, Sedlacek M. Impact of the surgeon on the prevalence of arteriovenous fistulas. ASAIO J., 2002, 48(1): 39-40.
    
    
33. Zheng F, HE C, Cai W, Hattori M, Steffes M, and Vlassara H. Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products. Diabetes Metab. Res. Rev. 2002, 18(3): 224-37.
    
    
34. Cai W, Gao QD, Zhu L, Peppa M, He C, and Vlassara H. Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction. Mol. Medicine, 2002, 8(7): 337-346.
    
    
35. Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, He C, Vlassara H. Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients. J Am Soc Nephrol. 2003 14(3): 728-31.
    
    
36. Peppa M, H C, Hattori M, McEvoy R, Zheng F, Vlassara H. Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice. Diabetes. 2003 52(6): 1441-8.
    
    
37. Sunamoto M, Husain M, He JC, Schwartz EJ, and Klotman PE. 2003. Critical role for Nef in HIV-1-induced podocyte dedifferentiation. Kidney Int. 64: 1695-1701.
    
    
38. Cai WJ, He JC, Zhu L, Pepper M, Lu CY, Uribarri J, and Vlassara H. 2004. High-Levels of Dietary AGE Transform LDL Into a Potent Redox-Sensitive MAPK Stimulant in Diabetic Patients. Circulation. 110: 285-291.
    
    
39. *He JC, Husain M, Sunamoto M, D’Agati V, Klotman M, Iyengar R, and Klotman P. 2004. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J. Clin. Invest. 114: 643-651.
    
    
40. LU CY, He JC, Cai W, Liu H, Zhu L, and Vlassara H. 2004. AGE-receptor-1 is a negative regulator of the RAGE-promoted inflammatory response to advanced glycation endproducts in mesangial cells. Proc. Natl. Acad. Sci. U.S.A. 101: 11767-11772.
    
    
41. Dedrick J, He JC, Eungdamrong J, De S Gomes I, Ali W, Bivona TG, Philip MR, Devi L, and Iyengar R. 2005. Gao-triggered proteasomal degradation of Rap1GAPII induces Rap1-dependent neurite outgrowth by cannabinoid receptors. J. Biol. Chem. 280:11413-21.
    
    
42. He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA, and Iyengar R. The Go/i coupled cannabinoid receptor mediated neurite outgrowth involves Rap regulation of Src and Stat3. J. Biol. Chem. 2005. 280:33426-34.
    
    
43. Scordi-Bello IA, Mosoin A, He JC, Chen Y, Cheng Y, Jarvis GA, Keller MJ, Hogarty K, Waller DP, Profy AT, Herold BC, and Klotman ME. Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action. Antimicrob. Agents. Chemother. 2005 49(9):3607-15.
    
    
44. Husain M, D’Agati V, He JC, Klotman ME, and Klotman PE. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS. 2005 19(17):1975-1980.
    
    
45. Cai W, He JC, Zhu L,Lu C, Vlassara H. Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor. Proc Natl Acad Sci U S A. 2006, 103(37):13801-6.
    
    
46. *He JC, Lu TC, Fleet M, Sunamoto M, Husain M, Fang W, Neves S, Chen Y, Shankland S, Iyengar R, and Klotman PE. Retinoic acid inhibits HIV-1 induced podocyte proliferation through the cAMP pathway. J. Am. Soc. Nephrol. 2007, 18: 93-102.
    
    
47. Cai W, He JC, Zhu L, Chen X, Wallenstein S, Striker GE, Vlassara H. Reduced Oxidant Stress and Extended Lifespan in Mice Exposed to a Low Glycotoxin Diet: Association with Increased AGER1 Expression. Am. J. Pathol. 2007 Jun;170(6):1893-902.
    
    
48. Chuang PY, Yu Q, Fang W, Uribarri J, and *He JC. Advanced glycation endproducts induce podocyte apoptosis via activation of FOXO4 transcription factor. Kidney Int. 2007 72(8):965-76.
    
    
49. Cai WJ, He JC, L Zhu, Srtriker G, and Vlassara H. AGER1 Counteracts Cellular Oxidant Stress Induced by AGEs via Negative Regulation of p66shc-dependent FKHRL1 Phosphorylation. Am J Physiol Cell Physiol. 2008 294: C145-152.
    
    
50. Linden E, Cai W, He JC, Chen X, Zhu L, Winston J, Vlassara H, and Uribarri J. Endothelial dysfunction in patients with chronic kidney disease results from Advanced Glycation Endproducts (AGE)-induced inhibition of endothelial nitric oxide synthase through RAGE activation. C. J Am. Soc. Nephrol 2008, 3:691-8.
    
    
51. Lu TC, *He JC, Wang ZH, Fukumi-Tominaga T, Yu Q, Iyengar R, and Klotman PE. HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein (DIP). J. Biol. Chem. 2008, 283:8173-82. (*corresponding and co-first author).
    
    
52. Korgaonkar SN, Ross MD, Lu TC, D’Agati V, Iyengar R, Klotman PE, and *He JC. HIV- infection causes an upregulation of Vascular Endothelial Growth Factor in podocytes. J. Am. Soc. Nephrol 2008, 19:877-83.
    
    
53. Cai W, He JC, Zhu L, Chen X, Zheng F, Striker GE, and Vlassara H. Oral Glycotoxins Determine the Efeects of Calorie Restriction on Oxidant Stress, Age-Related Diseases, and Lifespan. Am J Pathol 2008, 173(2):327-36.
    
    
54. Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R, Klotman PE, and He JC*. Retinoic acid utilizes a transcriptional “feed-forward” loop through CREB and USF1 to simulate MKP1 expression in HIV-infected podocytes. Mol Cell Biol 2008, 28(18):5785-94.
    
    
55. Dai S, Wang Z, Pan X, Chen X, Wang W, Ren H, Feng Q, He JC, Han B, Chen N. ACTN4 gene mutations and single nucleotide polymorphisms in idiopathic focal segmental glomerulosclerosis. Nephron Clin Pract. 2009, 111(2):c87-94.
    
    
56. Lu TC, Wang ZH, Feng X, Chuang PY, Fang W, Shen Y, Levy DE, Xiong H, Chen N, He JC*. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy. Kidney Int. 2009 76(1):63-71.
    
    
57. Liu W, Ouyang X, Yang J, Liu J, Li Q, Gu Y, Fukata M, Lin T, He JC, Abreu M, Unkeless JC, Mayer L, Xiong H. AP-1 Activated by Toll-like Receptors Regulates Expression of IL-23 p19. J Biol Chem. 2009, 284(36):24006-16.
    
    
58. Feng X, Lu TC, Chuang PY, Fang W, Krishna R, Xiong H, Ouyang X, Shen Y, Levy D, Hyink D, Klotman M, D’Agati V, Iyengar R, Klotman P, and He JC*. Knock-down of Stat3 activity in vivo attenuates HIV-induced kidney injury. J. Am Soc Nephrol 2009, Oct;20(10):2138-46.
    
    
59. Lipshtat A, Jayaraman G, He JC, and Iyengar R. Design of Versatile Biochemical Switches that respond to Amplitude, Duration and Spatial Cues. Proc Natl Acad Sci USA. 2010 Jan 19;107(3):1247-52
    
    
60. Cai W, Torreggiani M, Zhu L, Chen X, He JC, Striker GE, Vlassara H. AGER1 Regulates Endothelial Cell NADPH Oxidase-dependent Oxidant Stress via PKC{delta}; Implications for Vascular Disease. Am J Physiol Cell Physiol. 2010 Mar;298(3):C624-34.
    
    
61. Snyder A, Alsauskas ZC, Leventhal JS, Rosenstiel PE, Gong P, Chan JJ, Barley K, He JC, Klotman ME, Ross MJ, Klotman PE. HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells. AIDS. 2010 May 15;24(8):1107-19.
    
    
62. Mosoian A, Teixeira A, Burns CS, Sander LE, Gusella GL, He JC, Blander JM, Klotman P, Klotman ME. Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10178-83.
    
    
63. Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D'Agati VD, Klotman PE. Upregulation of the homophilic adhesion molecule Sidekick-1 in podocytes contributes to glomerulosclerosis. J Biol Chem. 2010 Aug 13;285(33):25677-85.
    
    
64. Ratnam K, Feng X, Chuang PY, Verma V, Lu TC, Farrias E, Wang S, Napoli J, Chambon P, D’Agati V, Iyengar R, Klotman PE, and *He JC. Role of Retinoic Acid Receptor-alpha in HIV-associated Nephropathy. (In revision).
    
    
65. Jin Y, Ratnam K, Chuang P, Chen N, D’Agati V, Chu T, Dan Y, Ross M, Iyengar R, Klotman P, Ma’ayan A, and *He JC. Identification of HIPK2 as a novel kinase for kidney tubulointerstitial fibrosis by systems biology analysis of genomic-wide mRNA profiling. (In revision)

Review articles:

1. HE CJ, YANG CW, PETEN EP, LIU ZH, PATEL A, STRIKER LJ, STRIKER GE. Collagen and collagenase mRNAs in normal and sclerotic glomeruli: Predictors of progression and response to therapy. Kidney Int., 1995, 47, Suppl 49: S39-S43.
   
   
2. Schroppel B and *He JC. Expression of Toll-like receptors in the kidney: their potential role beyond infection. Kidney Int. 2006, 69: 785-787.
   
3. Lu TC, He JC, and Klotman P. Animal models of HIV-associated nephropathy. Curr. Opin. Nephrol. Hypertens. 2006. 15: 233-7.
   
   
4. Shah SN, He JC, Klotman P. Update on HIV-associated nephropathy. Curr Opin Nephrol Hypertens. 2006. 15: 450-5.
   
   
5. *He JC, Neves S, Jordan JD, and Iyengar R. Role of Go/i signaling network in the regulation of neurite outgrowth. Can J Physiol Pharmacol. 2006, 84(7):687-694.
   
   
6. Lu TC, He JC, and Klotman PE. Podocyte injury in HIVAN. Nephron. 2007, 106:c67-71.
   
   
7. Bromberg K, Iyengar R, and *He JC. Regulation of neurite outgrowth by Gi/o signaling pathways. Front. Biosci. 2008, 13:4544-57.
   
   
8. Chuang P, *He JC. Signaling in Regulation of Podocyte Phenotypes. Nephron. 2009, 111:9-15.
   
   
9. Chuang P, *He JC. Role of Stat3 in kidney disease. Kidney Int. 2010, 78(3):231-4.
   
   
10. Ma'ayan A, *He JC. Protein kinase target discovery from genome-wide messenger RNA expression profiling. Mt Sinai J Med. 2010 Jul;77(4):345-9.