Projects and Grants
National Cancer Institute - NIH
Title: Functional determinants of metastatic dormancy.
Objective: to study the role of p53, BHLHB3 and ATF6 signaling pathways in the induction of dormancy and survival of dormant disseminated tumor cells in the bone marrow. Isolate and functionally characterize bone marrow disseminated tumor cells in different target organs.
Title: Plasticity of head and neck cancer initiating cells.
Objective: To determine whether tumor stem cell behavior in HNSCC follows a stochastic or hierarchical model.
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES.
Title: Translational Machinery in Stress Signaling and Tumor Suppression.
Objective: To determine the extent and mechanism by which TRM9 is down-regulated in tumors. To analyze the tumor suppressor and signaling mechanisms of TRM9. To determine whether a cross talk between ER-stress signaling and TRM9 regulates translational programs and tumor growth suppression. In collaboration with Thomas Begley, SUNY-Albany
Samuel Waxman Cancer Research Foundation
Title: Regulation of disseminated tumor cell fate by RAR and NR2F1 signaling.
Objective: to study the contribution through genetic and pharmacological approaches of RAR and NR2F1 to the dormancy of disseminated tumor cells to the bone marrow and lung in head and neck and breast cancer models. In collaboration with Eduardo Farias, MSSM.
Tisch Cancer Institute at Mount Sinai Developmental Grant.
Title: Analysis of the mechanisms of multiple myeloma sensitivity to salubrinal and Velcade.
Objective: to study the sensitivity of multiple myeloma cells derived from patients to the combination of salubrinal and Velcade.
Julio. A. Aguirre-Ghiso, MSc, PhD
1468 Madison Avenue
New York NY 10029