Recognition and Publications

Aguirre-Ghiso JA. On the theory of tumor self-seeding: implications for metastasis progression in humans. . Breast Cancer Res 2010 April; 12(2): 304.

Ossowski L, Aguirre-Ghiso J. Dormancy of metastatic melanoma. . Pigment Cell Melanoma Res. 2009 October; 23(1): 41-56.

Sequeira SJ, Wen H, Avivar Valderas A, Aguirre-Ghiso JA. Inhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. . BMC Cell Biology 2009 September; 10(64).

Adam AP, George A, Iglesias BV, Schewe D, Ranganathan A, Kourtidis A, Conklin DS, Aguirre-Ghiso JA. Computational identification of a p38SAPK regulated transcription factor network required for tumor cell quiescence. . Cancer Res. 2009 July; 15(69): 5664-5672.

Schewe DM, Aguirre-Ghiso JA. Inhibition of eIF2α dephosphorylation eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. . Cancer Res. 2009 Feb; 15(69): 1545-1552.
Schewe DM, Aguirre-Ghiso JA. ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. . Proc Natl Acad Sci U S A. 2008 Jul; 105(30): 10519-10524.

Ranganathan AC, Ohja S, Kourtidis A, Conkilin D, Aguirre-Ghiso JA, . Dual function of PERK in tumor cell growth arrest and survival. Cancer Res 2008; 68(9): 1-9.

Aguirre-Ghiso JA, . Models, mechanisms and clinical evidence for cancer dormancy. Nature Reviews Cancer 2007; 7(11): 834-846.

Sequeira SJ, Ranganathan AC, Adam AP, Iglesias BV, Farias EF, Aguirre-Ghiso JA. Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation. PLoS ONE 2007 Jul 18; 2: e615.

Shinohara M, Mikhailov AV, Aguirre-Ghiso JA, Rieder CL. ERK1/2 activation is required for timely progress through early G2 but it is not directly involved in the G2/M or M/A transitions in mammalian cells. Molecular Biology of the Cell 2006 Dec 1; 17: 5227-5240.

Chaurasia P, Aguirre-Ghiso JA, Liang OD, Gardsvoll H, Ploug M, Ossowski L. A region in uPAR domain III controlling a functional association with a5b1 integrin and tumor growth. J. Biol. Chem 2006 May 26; 281(21): 14852-14863.

Ranganathan AC, Zhang L, Adam AP, Aguirre-Ghiso JA. Functional coupling of p38-induced upregulation of BiP and activation of RNA-dependent protein kinase-like ER kinase (PERK) to drug resistance of dormant carcinoma cells. Cancer Research 2006; 66(3): 1702-1711.

Aguirre-Ghiso JA, Ossowski L, Rosenbaum SK. GFP tagging of ERK and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth.. Cancer Res 2004; 64(20): 7336-7345.