Julio. A. Aguirre-Ghiso, Ph.D.
Alfred Adomako, Ph.D.
Studies the mechanisms by which multiple myeloma may enter a state of quiescence or dormancy in response to therapy. This may reveal epigenetic and/or genetic mechanisms by which myeloma cells may persist dormant in a drug tolerant state and subsequently contribute to relapse.
Alvaro Avivar-Valderas, Ph.D.
Studies the role of the endoplasmic reticulum kinase PERK in regulating mammary acinar morphogenesis. He focuses on the role of PERK in inducing autophagy and growth arrest in mammary epithelial cells and how these mechanisms might be hijacked in early breast cancer lesions like DCIS.
Paloma Bragado, Ph.D.
Her work focuses on cancer "stem/initiating" cells in HNSCC and how epigenetic mechanisms might control a metastable tumorigenesis program in these cells. She also studies how the genes BHLHB41/Sharp-1 and p53 and p38 signaling regulate disseminated tumor cell fate and the switch between dormancy and metastatic expansion.
Yeriel Estrada, BSc
Mr. Estrada is the principal Laboratory Coordinator and participates in ongoing efforts in the HNSCC studies by other members in the lab. He also directs the functioning and development of our chicken embryo facility optimizing methods for xenograft and tumor stem cells studies in the embryos.
Studies the interplay between Wnt and p38 signaling during early dissemination and dormancy of early disseminated tumor cells.
Nina Linde, Ph.D.
Studies how macrophages contribute to early dissemination during pre-malignant stages of breast cancer. She also investigates how tissue macrophages influence the decision between dormant and proliferative behavior of disseminated tumor cells in the secondary site.
Develops and optimizes immunofluorescence and immunohistochemistry protocols to detect dormancy markers in human sample and participates in all projects on the analysis of clinical samples.
Maria Soledad Sosa, Ph.D.
Studies the role of p38 signaling in controlling the expression and function of transcription factors in the retinoic acid signaling pathway important for induction of tumor dormancy in HNSCC. She also develops a project studying how p38 signaling influences early dissemination in breast cancer.
Julio. A. Aguirre-Ghiso, MSc, PhD
1468 Madison Avenue
New York NY 10029