Projects and Grants
- The genetic and cellular mechanisms underlying the pathophysiology of diabetic cardiomyopathy
Objective: to investigate the consequences of diabetes on cardiac function and the role of insulin resistance and cardiometabolism dysregulation in contractile failure
- Proteomic and Genomic Profiling of Diabetes-induced Cardiac Dysfunction
Objective: to investigate the global changes in gene and protein expression profiles accompanying diabetic cardiomyopathy in human and animal models. Functional significance of potential new candidates and pathways are examined.
- Identification and Functional Characterization of SERCA2a-target Genes
Objective: to identify and characterize new target genes and proteins whose expression is altered by SERCA2a in heart failure.
- Electrical Remodeling and Cardiac Hypertrophy
Objective: to investigating the molecular and ionic basis of action potential prolongation in cardiac hypertrophy and failure using gene transfer of various K channels and chaperones.
NIH/NHLBI K01 HL076659
Electrical Remodeling and Cardiac Hypertrophy and Signaling
NIH/NHLBI R01 HL 07873
Genetic Editing of Calcium Cycling in Diabetic Cardiomyopathy