Projects and Grants

The following is a list of projects being conducted in the Liver Research Laboratory of Dr. Scott Friedman:

• Role of KLF6 in lipid and glucose homeostasis through study of mice with KLF6 depletion
  Investigators: Lars Bechmann, MD and Peri Kocabayoglu, MD
  
  
• Analysis of KLF6 SV1-specific targets using in vivo models
  Investigator: Diana Vetter, MD
  
  
• In vivo imaging of KLF6 splicing using novel reporter mice
  Investigator: Rebekka Hannivoort, MD
  
  
• Molecular regulation of KLF6 splicing by cytokines
  Investigator: Ursula Munoz Moron, PhD
  
  
• High throughput small molecule screening of KLF6 splicing inhibitors
  Investigator: David Zhang
  
  
• In vivo antagonism of KLF6 SV1 for HCC therapy
  Investigator: Michal Cohen, MD
  
  
• Regulation of cell growth via interaction of KLF6 with GSK3beta
  Investigator: Ursula Lee
  
  
• Characterization of transgenic promoters for stellate cell gene expression in vivo
  Investigator: Young Min Lee, MD
  
  
• Role of KLF6 in hepatic fibrosis
  Investigator: Zahra Ghiassi-Nejad
  
  
• Molecular regulation of stellate cell activation
  Investigator: Virginia Hernandez-Gea, MD
  
  
• Molecular basis for genetic regulation of hepatic fibrosis
  Investigator: Ori Rackovsky
  
  
• Antifibrotic activity of small molecules in cultured stellate cells and in vivo
  Investigators: Feng Hong, MD and Hsin Chou, MS
  
  
• Stellate cell inhibition in vivo
  Investigator: Juan Enrique Puche Garcia, MD, PhD
  
  
• Impact of hepatic fibrosis on liver regeneration
  Investigator: Juan Suarez-Cuenca, MD, PhD