Trainee Publications

Olaso E, Ikeda K, Eng F, Xu L, Wang L, Lin HC, Yancopoulos G, and Friedman SL. DDR2 receptor promotes MMP-2 mediated proliferation and invasion of hepatic stellate cells during liver injury.  J Clin Investigation, 108: 1369-78, 2001.

Narla G, Heath K, Reeves H, Li D, Giono LE, , Narla J, Glucksman M, Kimmelman  A, Eng FJ, Chan A, Ferrari A, Martignetti J and Friedman SL.   Kruppel-like factor 6, a candidate tumor suppressor gene  mutated in prostate cancer. Science, 294:2563-5, 2001.

Olaso E, Labrador P,  Wang L,  Ikeda K,  Eng F,  Klein R,  Lovett DH,  Lin HC, and Friedman SL. DDR2 receptor regulates fibroblast proliferation and invasion by transcriptional activation of MMP-2.  J Biol Chem, 277: 3606-3613, 2002.

Reeve H, Arthur MJP, Martignetti JA, Friedman SL.  Kruppel like factor 6 (KLF6) is a tumor suppressor gene frequently inactivated in colorectal cancer.   Gastroenterology,126:1090-1103, 2004.

Benzeno B, Narla G, Allina J, Cheng GZ, Reeves HL, Banck MS, Odin JA, Diehl JA, Germain G, Friedman SL. Cyclin dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.  Cancer Research, 64(11):3885-91, 2004.

Safadi R, Ohta M, Alvarez CE, Fiel MI, Bansal M, Mehal WZ, and Friedman SL.  Immune stimulation of hepatic fibrosis by CD8 T cells and its attenuation by transgenic IL10 from hepatocytes. Gastroenterology, 127:870-882, 2004.

Kremer-Tal  S, Reeves  HL, Narla  G, Thung  SN, Schwartz  M, Difeo A, Katz A, Bruix J, Bioulac-Sage B, Martignetti JA,      Friedman SL.  Frequent inactivation of the tumor suppressor Kruppel like factor 6 (KLF6) in hepatocellular carcinoma.     Hepatology, 40:1047-1052, 2004.

Li D, Yea S,  Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ  and Friedman SL.  Regulation of Krüppel-like factor 6  tumor suppressor activity by acetylation.  Cancer Research, 65(20):9216-9225, 2005.

Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F, Keller G, and Friedman SL. Developmental regulation of   yolk-sac hematopoiesis by Krüppel-like Factor  6.  Blood, 107 (4), 1357-1365,  2006.

Yea S, Narla G, Zhao X, Garg R, Tal-Kremer S , Hod H, Villanueva A, Loke J, Tarocchi M, Akita K,  Shirasawa S, Sasazuki T, Martignetti JA, Llovet JM,  Friedman SL.  Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.  Gastroenterology, 135(1):326, 2008.

Guo J, Loke J, Zheng F, Hong F, Yea S, Fugita M, Tarocchi M, Abar OT, Huang H, Sninsky JJ, Friedman SL.  Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses.  Hepatology, 49(3):960-8, 2009.


Contact Us

Scott Friedman, MD
Tel: 212-659-9510
Fax: 212-849-2574
Send e-mail

Icahn Building
1425 Madison Avenue,11th Floor
Room 11-76
Box 1123
New York, NY 10029