Immunity – New Study Identifies the Contribution of Human Dendritic Cells Subsets to Flu Immunity

Study reveals the striking similarity between human DC that populate human lungs and the lungs of humanized mice.

 – April 4, 2013 /Press Release/  –– 

Study reveals the striking similarity between human DC that populate human lungs and the lungs of humanized mice. Long Summary: A new study published in Immunity this week by Merad Laboratory in collaboration with Karolina Palucka’s group identifies the contribution of human dendritic cells subsets to Flu immunity. Using humanized mice and human lungs , the study reveals the striking similarity between human DC that populate human lungs and the lungs of humanized mice, and establishes the key role of human CD1c+ DC to the induction of flu specific intraepithelial T cells.

Chun Yu, Christian Becker, Florentina Marches, Kristina Goller, Jacques Banchereau, Miriam Merad* and Karolina Palucka*. Human CD1c+ dendritic cells drive the differentiation of CD103+ intraepithelial CD8+ T cells via TGFb1. Immunity. 2013 Apr 18;38(4):818-30. (*: contributed equally)

Learn more about the study.