Nature Medicine - New Study Reveals the Role of Macrophages in Erythropoiesis
Andrew Chow, a MD/PhD student who works in Dr. Merad’s and Dr. Frenette’s laboratories, is the author of a new study published in Nature Medicine that reveals the role of macrophages in erythropoiesis. Erythroblastic islands are composed of a central macrophage and develop red blood cells that have been described since 1958, but demonstrating the functional relevance of these structures in vivo has been elusive. The Merad and Frenette laboratories now report that CD169+ macrophages in the BM and splenic red pulp are critical in the recovery from erythropoietic stress and contribute to the pathogenesis of polycythemia vera.
CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. Nat Med. 2013 Mar 17. doi: 10.1038/nm. 3057
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