The Tumor Immune Microenvironment
Dendritic cells (DC) and macrophages are prominent components of the tumor microenvironment and can induce anti-tumor immunity by virtue of their function as antigen presenting cells. These cells promote tumor growth through the release of potent soluble mediators that regulate tumor cell proliferation or survival.
One of the primary goals of our laboratory is to understand the contribution of mononuclear phagocyte to tumor homeostasis, tumor immunity, and to tumor response to chemotherapy. Using mainly endogenous tumor models, and when necessary, tumor grafts, we study the mechanisms that control the recruitment and survival of phagocytes at the tumor site. We also examine the interaction between tumor cells and phagocytes, and the mechanisms that control the induction of potent and therapeutic antitumor immunity.