The Merad Laboratory at the Icahn School of Medicine at Mount Sinai is a research laboratory that studies the mechanisms that regulate the development and function of dendritic cells and macrophages, and their contribution to the induction of immune responses against pathogens and tumor cells in vivo. Dendritic cells and macrophages form a small subset of hematopoietic cells that populate most tissues and are enriched in interface tissues. The primary role of these cells is to sense tissue injuries and shape innate and adaptive immune responses to pathogens that breach tissue. The primary goal of the laboratory is to dissect the regulatory mechanisms that control the development and function of these cells, in hopes that this knowledge will eventually lead to the development of novel clinical tools that will induce or restore immunity in human patients.
Dr. Miriam Merad is a Professor of Oncological Sciences, a Professor of Medicine (Hem/Onc division), the program leader of the Cancer Immunology and Immunotherapy program at the Tisch Cancer Institute, and the Director of the Human Immunology Center at the Ichan School of Medicine at Mount Sinai. Read more