Recognition and Publications

  1. Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, LeRoith D. Insulin-like growth factor-1 protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum. Cell Death Differ 2008; 15:1304-1317.
  2. Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, Yakar S, Sadler KC, LeRoith D. The role of insulin receptor signaling in zebrafish embryogenesis. Endocrinology 2008; 149:5996-6005.
  3. Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J 2009; 23:709-719.
  4. Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen K, LeRoith D. Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis. Bone 2009; 44:648-655.
  5. Kawashima Y, Chen H, Sun H, Lann D, Hajjar RJ, Yakar S, LeRoith D. Apolipoprotein E deficiency abrogates insulin resistance in a mouse model type 2 diabetes mellitus. Diabetologia 2009 Jul; 52(7):1434-1441.
  6. Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, Digirolamo DJ, Kopchick JJ, LeRoith D, Trucco M, Sperling MA. Liver-specific deletion of the growth hormone receptor reveals essential role of GH signaling in hepatic lipid metabolism. J Biol Chem 2009 Jul; 284(30):19937-19944.
  7. Novosyadlyy R, Vijayakumar A, Lann D, Fierz Y, Kurshan N, LeRoith D. Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-1 receptors is required for oncogene activation and tumor initiation. Oncogene 2009 Oct; 28(39):3477-3486.
  8. Wu Y, Sun H, Yakar S, LeRoith D. Elevated levels of insulin-like growth factor-1 in serum reduce the severe growth retardation of IGF-1 null mice. Endocrinology 2009; 150:4395-4403.
  9. Novosyadlyy R, Lann DE, Vijayakumar A, Rowzee A, Lazzarino DA, Fierz Y, Carboni JM, Gottardis MM, Pennisi PA, Molinolo AA, Kurshan N, Mejia W, Santopietro S, Yakar S, Wood TL, LeRoith D. Insulin-mediated acceleration of breast cancer development and progression in a non-obese model of type 2 diabetes. Cancer Research 2010 Jan; 70(2):741-751.
  10. Fierz Y, Novosyadlyy R, Vijayakumar A, LeRoith D. Insulin-sensitizing therapy abrogates accelerated breast cancer progression in a mouse model of type 2 diabetes. Diabetes 2010; 59:686-693.


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