Mlodzik Lab - Publications

Selected Publications (in chronological order since 1994; out of total of 111)

Peer Review Original Research Articles

Bohmann, D., Ellis, M.C., Staszewski, L.M. and Mlodzik, M. (1994). Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78, 973-986.

Strutt, D.I., Wiersdorff, V. and Mlodzik, M. (1995). Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature 373, 705-709.

Treier, M., Bohmann, D. and Mlodzik, M. (1995). Jun cooperates with the ETS-domain protein Pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell 83, 753-760.

Zeidler, M., Yokomori, K., Tjian, R. and Mlodzik, M. (1996). Drosophila TFIIA-S is up-regulated and required during Ras mediated photoreceptor determination. Genes & Dev. 10, 50-59.

Yuan, Y.P., Schultz, J., Mlodzik, M. and Bork, P. (1997). Secreted Fringe-like glycosyltransferases as signaling molecules in pattern formation. Cell 87, 9-11.

Strutt, D.I., Weber, U. and Mlodzik, M. (1997). The role of RhoA in tissue polarity and Frizzled signalling. Nature 387, 292-296.

Kockel, L., Zeitlinger, J., Staszewski, L.M., *Bohmann, D. and *Mlodzik, M (1997). Jun in Drosophila development: Redundant and non-redundant functions, and regulation by two MAPK signal transduction pathways. Genes & Dev. 11, 1748-1758. *co-senior and corresponding authors

Boutros, M., Paricio, N., Strutt, D.I. and Mlodzik, M. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94, 109-118.

Fanto, M. and Mlodzik, M. (1999). Asymmetric Notch activation downstream of Frizzled signaling specifies photoreceptors R3 and R4 and generates planar polarity in the Drosophila eye. Nature 397, 523-526.

Curtiss, J. and Mlodzik, M. (2000). Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent. Development 127, 1325-1336.

Pazman, C., Mayes, C.A., Fanto, M., Haynes, S. and Mlodzik, M. (2000). Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in Ras and Rho mediated signaling. Development 127, 1715-1725.

Weber, U., Paricio, N., and Mlodzik, M. (2000). Jun mediates Frizzled induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 127, 3619-3629.

Boutros, M., Mihaly, J., Bouwmeester, T. and Mlodzik, M. (2000). Signaling specificity by Frizzled in Drosophila. Science, 288, 1825-1828.

Fanto, M., Weber, U. Strutt, D.I. and Mlodzik, M. (2000). Specific roles of Rho and Rac downstream of Frizzled in planar polarity signaling. Current Biology, 10, 979-988.

Mihaly, J., Kockel, L., Gaengel, K., Weber, U. Bohmann, D. and Mlodzik, M. (2001). The role of the Drosophila TAK homologue dTAK in development. Mech Dev. 102, 67-79.

Ciapponi, L., Jackson, D., Mlodzik, M. and Bohmann, D. (2001). Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes & Dev. 15, 1540-1553.

Feiguin, F., Hannus, M., Mlodzik, M. and Eaton, S. (2001). The Ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization and formation of proximal-distal cortical domains. Developmental Cell 1, 93-101.

Darken, R., Scola, A., Rakeman, A., Das, G., Mlodzik, M. and Wilson, P.A. (2002). The planar polarity gene Strabismus regulates convergent extension movements in Xenopus. EMBO J. 21, 976-985.

Das, G., Reynolds-Kenneally, J. and Mlodzik, M. (2002). The atypical Cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye. Developmental Cell 2, 655-666.

Jenny, A., Darken, R. Wilson, P.A. and Mlodzik, M. (2003). Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. EMBO J., 22, 4409-4420.

Kenyon, K.L., Ranade, S.S., Curtiss, J., Mlodzik, M. and Pignoni, F. (2003). Coordinating proliferation and tissue specification to promote regional identity in the Drosophila head. Developmental Cell, 5, 403-414.

Gaengel, K. and Mlodzik, M, (2003). EGF-Receptor signaling regulates ommatidial rotation and cell motility in the Drosophila eye via the Ras effector Canoe/AF-6. Development, 130, 5413-5423.

Weber, U., Eroglu, C. and Mlodzik, M. (2003). Phospholipid membrane composition affects EGF-Receptor and Notch signaling through effects on membrane traffic during Drosophila development. Dev. Cell, 5, 559-570.

Wong, H.-C., Bourdelas, A., Krauss, A., Lee, H.-J. Shao, Y., Wu, D., Mlodzik, M., Shi, D.-L. and Zheng, J. (2003). Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Molecular Cell, 12, 1251-1260.

Wu, J., Klein, T..J. and Mlodzik, M. (2004). Subcellular localization of Frizzled receptors, mediated by their cytoplasmic tails, regulates signaling specificity and read-out. PLoS Biology, 2, 1004-1014.

Das, G., Jenny, A., Klein, T..J., Eaton, S., and Mlodzik, M (2004). Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development, 131, 4467-4476.

Domingos, P.M., Mlodzik, M., Mendes, C.S., Brown, S., Steller, H. and Mollereau, B. (2004). Spalt transcription factors are required for R3/R4 specification and establishment of planar cell polarity in the Drosophila eye. Development, 131, 5695-702.

Simons, M., Gloy, J., Ganner, A., Bullerkote, A., Bashkurov, M., Kroenig, C., Schermer, B., Bemzing, T., Cabello, O.A., Jenny, A., Mlodzik, M., Polok, B., Driever, W., Obara, T., and Walz G. (2005). Inversin, the nephronophthisis type II gene product, functions as a molecular switch between Wnt signaling pathways. Nature Genetics, 37, 537-543.

Djiane, A., Yogev, S., and Mlodzik, M. (2005). The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye. Cell 121, 621-631.

Jenny, A., Reynolds-Kenneally, J., Das, G., Burnett, M. and Mlodzik, M. (2005). Dishevelled is protected by Diego from the antagonistic effect of the Stbm/Prickle complex during Fizzled-PCP signaling. Nature Cell Biology 7, 691-697.

Dollar, G., Weber, U., Mlodzik, M., and Sokol, S., (2005). Regulation of Lethal Giant Larvae by Dishevelled. Nature 437, 1376-1380.

Reynolds-Kenneally, J., and Mlodzik, M. (2005). Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye. Developmental Biology 285, 38-48.

Ciruna, B., Jenny A., Lee, D., Mlodzik, M., and Schier A.F. (2006). Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature, 439, 220-224.

Matusek, T., Djiane A., *Mihaly, J. and *Mlodzik M. (2006). The Drosophila formin dDAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton. Development, 133, 957-966. *co-corresponding authors.

Delaney, J.R., Stöven, S., Uvell, H., Anderson, K.V., Engström, Y. and Mlodzik, M. (2006). Cooperative control of Drosophila immune responses by the JNK and NF-kB signaling pathways. EMBO J., 25, 3068-3077.

Klein, T.J., Jenny A., Djiane, A. and Mlodzik, M. (2006). CKIe/discs overgrown promotes both Wnt-Fz/b-Catenin and Fz/PCP signaling in Drosophila. Current Biology, 11, 1337-1343.

Mirkovic, I. and Mlodzik M. (2006). Cooperative activities of Drosophila DE-Cadherin and DN-Cadherin regulate the cell motility process of ommatidial rotation. Development, 133, 3283-3293.

Moeller, H., Jenny, A., Schaeffer, H-J., Schwarz-Romond, T., Mlodzik, M., Hammerschmidt, M. and Birchmeier, W (2006). Diversin regulates heart formation and gastrulation movements in development. Proc. Natl. Acad. Sci. (USA), 103, 15900-15905.

Del Alamo, D. and Mlodzik, M. (2006). Frizzled/PCP signaling dependent asymmetric Neuralized expression determines planar cell polarity and R3/R4 fates in the Drosophila eye. Developmental Cell, 11, 887-894.

Curtiss, J., Burnett, M. and Mlodzik, M. (2007). Distal antenna and distal antenna related function in the retinal determination network during eye development in Drosophila. Developmental Biology, 306, 685-702.

Munoz-Descalzo, S., Gomez-Cabrero, A., Mlodzik, M. and Paricio, N. (2007). Analysis of the role of the Rac/Cdc42 GTPases during planar cell polarity generation in Drosophila. Int. J. Dev. Biology, 51, 379-387.

Montrasio, S., Mlodzik, M. and Fanto, M. (2007). A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye. Dev. Dynamics, 236, 2936-2942.

Gaengel K., and Mlodzik M. (2008). Microscopic analysis of the adult Drosophila retina using semi-thin plastic sections. Methods Molecular Biology, 420, 277-287.

Wu, J., Jenny, A., Mirkovic, I. and Mlodzik, M. (2008). Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila. Mech. Development, 125, 30-42.

Weber, U., Pataki, S., Mihaly, J., and Mlodzik, M. (2008). Combinatorial signaling by the Frizzled/PCP and Egfr-pathways during planar cell polarity establishment in the Drosophila eye. Developmental Biology 316, 110-123.

Jenny, A., and Mlodzik, M. (2008). Modified vector for the two-step directional cloning of inverted repeats for RNA interference in Drosophila. BioTechniques, 44, 335-339.

Del Alamo, D. and Mlodzik, M. (2008). Self-modulation of Notch signaling during ommatidial development via the roughened eye transcriptional repressor. Development, 135, 2895-2904.

Wu, J., and Mlodzik, M., (2008). The Frizzled extracellular domain is ligand for Van Gogh/Stbm during non-autonomous planar cell polarity signaling. Developmental Cell, in press.

Invited Reviews (selected since 1999; out of a total of 19)

Mlodzik, M. (1999). Planar polarity in the Drosophila eye: a multifacetted view of signaling specificity and crosstalk. EMBO J. 18, 6873-6879.

Mlodzik, M. (2000). Spiny Legs and Prickled Bodies: New insights and complexities in planar polarity establishment. Bioessays 22, 311-315.

Curtiss, J., Halder, G. and Mlodzik, M. (2002). Selector and signaling molecules cooperate in organ patterning. Nature Cell Biol. 4, 48-51.

Mlodzik, M. (2002). Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genetics, 18, 564-571.

Klein, T.J., and Mlodzik M. (2004). A conserved signaling cassette regulates hair patterning from Drosophila to man. Proc. Natl. Acad. Sci., 101, 9173-0174.

Klein, T.J., and Mlodzik, M. (2005). Planar cell polarization: An emerging model points in the right direction. Annual Reviews in Cell and Dev. Biology, 21, 155-176

Mlodzik, M. (2006). A GAP in convergernt extension scores a PAR. Developmental Cell, 11, 2-4.

Delaney, J.R. and Mlodzik, M. (2006). TGF-β Activated Kinase-1: new insights into the diverse roles of TAK1 in development. Cell Cycle, 5, 2852-2855.

Seifert, J. R. K., and Mlodzik, M (2007) Frizzled/PCP signaling: a conserved mechanism regulating cell polarity and directed motility. Nature Reviews Genetics, 8, 126-138.

Simons, M., and Mlodzik, M. (2008). Planar Cell Polarity: from Fly Development to Human Disease. Annual Reviews in Genetics, in press.