We study host-virus interactions, vaccines and antivirals, and virulence factors of RNA viruses.
Virology, Influenza, Recombinant DNA
Our group is interested in fundamental questions concerning the genetic make-up and the biology of viruses. We use molecular biological techniques to understand how viruses replicate and how they interact with cells to cause disease in their hosts. Emphasis is on the study of RNA viruses, including influenza, paramyxo and corona (SARS) viruses.
There are four major research directions in our laboratory at the present time. (1) By genetically changing influenza viruses via recombinant DNA techniques, we are studying viral genes and gene products. Using these reverse genetics techniques, we are trying to develop novel influenza virus vaccines and vaccine vectors. (2) We are identifying intracellular proteins that interact with viral proteins, and we are studying the biological function(s) of these cellular proteins. (3) Another interest is the identification of novel targets for antivirals. (4) Finally, we are studying the pathogenicity of viruses in animal models including transmission of influenza viruses in guinea pigs.
We are interested in training students and postdoctoral fellows who will become independent investigators in "molecular" studies of infectious viral diseases.