Recognition and Publications

Neve, L.R. and Robakis, N.K. (1998). Alzheimer Disease: A Re-Examination of the Amyloid Hypothesis. Trends in Neuroscience (TINS) 21: 15-19.

Gorgakopoulos, A., Marambaud, P., Efthimiopoulos, S., Shioi, J., Cui, W., Li, C., Schütte, M., Gordon, R., Holstein, G. R., Martinelli, G., Mehta, P., Friedrich, V. L-.Jr., Robakis N. K. (1999). Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell-Cell Adhesion System and is Recruited to Intercellular and Synaptic Contacts. Mol. Cell, 4: 893-902.

Baki, L., Marambaud. P, Efthimiopoulos S., Georgakopoulos S., Wen, P., Cui, W., Ozawa, M., Friedrich L., and Robakis, N.K. (2001) Presenilin1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc. Natl. Acad. Sci. USA 98: 2381-2386.

Marambaud, P., Wen, P., Dutt, A., Shioi, J., Siman, R., Takashima, A., and Robakis, N.K. (2003) A CBP-binding transcriptional repressor produced by the PS1/-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114: 635-645 [for commentaries on this paper see Nature 425: 565-566 (2003) and Cell, 114: 533-535 (2003)].

Baki, L., Shioi, J., Wen, P., Shao, Z., Schwarzman, A., Gama-Sosa, M., Neve, R., and Robakis, NK. (2004). PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J.23: 2586-2596.

Georgakopoulos, A., Litterst, C., Ghersi, E., Baki, L., Xu, C.J., Serban, G., and Robakis, N.K. (2006). Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 25: 1242-52.

Litterst, C., Georgakopoulos A., Shioi J., Ghersi, E., Wisniewski, T., Wang, R., Ludwig, A., Robakis, NK. (2007). Ligand binding and calcium influx induce distinct ectodomain/g-secretase processing pathways of EphB2 receptor. J. Biol. Chem. 282: 16155-16163.

Baki, L., Neve, R., Shao, Z., Shioi, J., Georgakopoulos A., and Robakis, NK., (2008). Wild-type but not FAD mutant Presenilin-1, prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase survival signaling. J. Neurosci. 28: 483– 490.

Kouchi, Z., Barthet G., Serban G., Georgakopoulos A., Shioi J., and Nikolaos NK., (2009). P120 catenin inhibits production of abeta and AICD by recruiting cadherin substrates to g-secretase. J. Biol. Chem. 284:1954-61. Epub 2008 Nov 13.

Xu, J., Litterst, C., Georgakopoulos, A., Zaganas, I., and Robakis NK (2009). Peptide EphB2/CTF2 generated by the g-secretase processing of EphB2 receptor, promotes tyrosine phosphorylation and cell surface localization of NMDA receptors. J. Biol. Chem., 284: 27220–27228.

Robakis, NK. (2010). Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives. Neurobiol. Aging. doi:10.1016/j.nerobiolaging.2010.05.022.

Pimplikar SW., Nixon RA, Robakis NK, Shen J. and Tsai LH., (2010) J. Neurosci. 30: 14946 –14954