Recognition and Publications

Gorgakopoulos, A., Marambaud, P., Efthimiopoulos, S., Shioi, J., Cui, W., Li, C., Schütte, M., Gordon, R., Holstein, G. R., Martinelli, G., Mehta, P., Friedrich, V. L-.Jr., Robakis N. K. (1999). Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell-Cell Adhesion System and is Recruited to Intercellular and Synaptic Contacts. Mol. Cell, 4: 893-902.

Baki, L., Marambaud. P, Efthimiopoulos S., Georgakopoulos S., Wen, P., Cui, W., Ozawa, M., Friedrich L., and Robakis, N.K. (2001) Presenilin1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc. Natl. Acad. Sci. USA 98: 2381-2386.

Marambaud, P., Wen, P., Dutt, A., Shioi, J., Siman, R., Takashima, A., and Robakis, N.K. (2003) A CBP-binding transcriptional repressor produced by the PS1/-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114: 635-645 [for commentaries on this paper see Nature 425: 565-566 (2003) and Cell, 114: 533-535 (2003)].

Georgakopoulos, A., Litterst, C., Ghersi, E., Baki, L., Xu, C.J., Serban, G., and Robakis, N.K. (2006). Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 25: 1242-52.

Litterst, C., Georgakopoulos A., Shioi J., Ghersi, E., Wisniewski, T., Wang, R., Ludwig, A., Robakis, NK. (2007). Ligand binding and calcium influx induce distinct ectodomain/g-secretase processing pathways of EphB2 receptor. J. Biol. Chem. 282: 16155-16163.

Baki, L., Neve, R., Shao, Z., Shioi, J., Georgakopoulos A., and Robakis, NK., (2008). Wild-type but not FAD mutant Presenilin-1, prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase survival signaling. J. Neurosci. 28: 483– 490.

Xu, J., Litterst, C., Georgakopoulos, A., Zaganas, I., and Robakis NK (2009). Peptide EphB2/CTF2 generated by the g-secretase processing of EphB2 receptor, promotes tyrosine phosphorylation and cell surface localization of NMDA receptors. J. Biol. Chem., 284: 27220–27228.

Robakis, NK. (2010). Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives. Neurobiol. Aging. doi:10.1016/j.nerobiolaging.2010.05.022.

Pimplikar SW., Nixon RA, Robakis NK, Shen J. and Tsai LH., (2010) J. Neurosci. 30: 14946 –14954

Georgakopoulos, A., Xu, J. Xu, C.J., Mauger, G. and Robakis, N.K. (2011) “Presenilin1/γ-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein.” FASEB J. 25(10): 3594-3604.

Xu, J., Xilouri, M., Bruban, J., Shioi, J., Shao, Z., Papazoglou, I., Vekrellis, K., Robakis, N.K. (2011) “Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.” Neurobiol. Aging 32(12): 2326.e5-2326.e16

Barthet, G., Dunys, J., Shao, Z., Xuan, Z., Ren, Y., Xu, J., Arbez, N., Mauger, G., Bruban, J., Georgakopoulos, A., Shioi, J. and Robakis, N.K. (2012b)  “Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors.” Neurobiol. Aging 34(2): 499-510.

Barthet, G., Georgakopoulos, A. and Robakis, N.K. (2012a) “Cellular mechanisms of γ-secretase substrate selection, processing and toxicity.” Prog. Neurobiol. 98: 166-175.

Robakis, N.K. and Georgakopoulos A. (2013) “Allelic interference: A mechanism for trans-dominant transmission of loss of function in the neurodegeneration of Familial Alzheimer’s Disease.” Neurodegener. Dis. [Epub ahead of print]

Xuan, Z., Barthet, G., Shioi, J., Xu, J., Georgakopoulos, A., Bruban, J. and Robakis, N.K. (2013) “Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation and surface expression of NMDAR subunit NR2B.” J. Biol. Chem. 288(42): 30495-30501.

Contact Us

Nikolaos Robakis
Tel: 212-241-9380; 212-241-9304;
212-241-9378; 212-241-9087  
Fax: 212-241-0760
Send e-mail

Icahn School of Medicine
Box 1229
One Gustave L. Levy Place
New York, NY 10029


Annenberg Building
Rooms 22-70 and 22-38

Annenberg Building
Room 22-64