Recognition and Publications

Wang Q, Chikina M, Zaslavsky E, Pincas H, Sealfon SC. β-catenin regulates GnRH-induced FSHβ gene expression. Mol Endocrinol. 2012 Dec 4. 

Hartmann BM, Li W, Jia J, Patil S, Marjanovic N, Martínez-Romero C, Albrecht RA, Hayot F, García-Sastre A, Wetmur J, Moran T, Sealfon SC. Mouse dendritic cell influenza virus infectivity is much lower than for human and is hemagglutinin subtype dependent. J Virol. 2012 Nov 28. 

Braun DA, Fribourg M, Sealfon SC. Cytokine response is determined by duration of receptor and STAT3 activation. J Biol Chem. 2012 Nov 19.

Nair VD, Ge Y, Balasubramaniyan N, Kim J, Okawa Y, Chikina M, Troyanskaya O, Sealfon SC. Involvement of Histone Demethylase LSD1 in Short-Time-Scale Gene Expression Changes during Cell Cycle Progression in Embryonic Stem Cells. Mol Cell Biol. 2012 Dec;32(23):4861-76. 

Ge Y, Sealfon SC. flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding. Bioinformatics. 2012 Aug 1;28(15):2052-8.

Choi SG, Jia J, Pfeffer RL, Sealfon SC. G proteins and autocrine signaling differentially regulate gonadotropin subunit expression in pituitary gonadotrope. J Biol Chem. 2012 Jun 15;287(25):21550-60.

Zaslavsky E, Hayot F, Sealfon SC. Computational approaches to understanding dendritic cell responses to influenza virus infection. Immunol Res. 2012 Dec;54(1-3):160-8.

Yuen T, Choi SG, Pincas H, Waring DW, Sealfon SC, Turgeon JL. Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes. Mol Cell Endocrinol. 2011 Nov 25.

Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, Mackerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs. Cell. 2011 Nov 23;147(5):1011-23. 

Albizu L, Holloway T, González-Maeso J, Sealfon SC. Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology. 2011 Sep;61(4):770-7. 

Choi SG, Ruf-Zamojski F, Pincas H, Roysam B, Sealfon SC. Characterization of a MAPK scaffolding protein logic gate in gonadotropes. Mol Endocrinol. 2011 Jun;25(6):1027-39.

Hu J, Nudelman G, Shimoni Y, Kumar M, Ding Y, López C, Hayot F, Wetmur JG, Sealfon SC. Role of cell-to-cell variability in activating a positive feedback antiviral response in human dendritic cells. PLoS One. 2011 Feb 8;6(2):e16614.

Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett. 2011 Apr 15;493(3):76-9.

Sugár IP, Sealfon SC. Misty Mountain clustering: application to fast unsupervised flow cytometry gating. BMC Bioinformatics. 2010 Oct 9;11:502.

Patil S, Pincas H, Seto J, Nudelman G, Nudelman I, Sealfon SC. Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase. BMC Syst Biol. 2010 Oct 7;4:137.

Bowles R, Patil S, Pincas H, Sealfon SC. Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation. J Immunol Methods. 2010 Dec 15;363(1):21-8.

Seto J, Qiao L, Guenzel CA, Xiao S, Shaw ML, Hayot F, Sealfon SC. Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study. J Virol. 2010 Nov;84(21):10965-73.

Fink MY, Pincas H, Choi SG, Nudelman G, Sealfon SC. Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: A pathway-based web-accessible knowledgebase. Mol Endocrinol. 2010 Sep;24(9):1863-71.

Shimoni Y, Fink MY, Choi SG, Sealfon SC. Plato's Cave Algorithm: Inferring Functional Signaling Networks from Early Gene Expression Shadows. PLoS Comput Biol. 2010 Jun 24;6(6):e1000828.

Qiao L, Phipps-Yonas H, Hartmann B, Moran TM, Sealfon SC, Hayot F. Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells. Biophys J. 2010 Feb 17;98(4):505-14.

Zaslavsky E, Hershberg U, Seto J, Pham AM, Marquez S, Duke JL, Wetmur JG, Tenoever BR, Sealfon SC, Kleinstein SH. Antiviral response dictated by choreographed cascade of transcription factors. J Immunol. 2010 Mar 15;184(6):2908-17.

Hu J, Iyer-Biswas S, Sealfon SC, Wetmur J, Jayaprakash C, Hayot F. Power-laws in interferon-B mRNA distribution in virus-infected dendritic cells. Biophys J. 2009 Oct 7;97(7):1984-9.

Nudelman G, Ge Y, Hu J, Kumar M, Seto J, Duke JL, Kleinstein SH, Hayot F, Sealfon SC, Wetmur JG. Coregulation mapping based on individual phenotypic variation in response to virus infection. Immunome Res. 2010 Mar 18;6(1):2.

Yuen T, Ruf F, Chu T, Sealfon SC. Microtranscriptome regulation by gonadotropin-releasing hormone. Mol Cell Endocrinol. 2009 Apr 10;302(1):12-7.

González-Maeso J, Sealfon SC. Psychedelics and schizophrenia. Trends Neurosci. 2009 Apr;32(4):225-32.

Bordería AV, Hartmann BM, Fernandez-Sesma A, Moran TM, Sealfon SC. Antiviral-activated dendritic cells: a paracrine-induced response state. J Immunol. 2008 Nov 15;181(10):6872-81.

Phipps-Yonas H, Seto J, Sealfon SC, Moran TM, Fernandez-Sesma A. Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. PLoS Pathog. 2008 Oct;4(10):e1000193.

Viswanathan GA, Seto J, Patil S, Nudelman G, Sealfon SC. Getting started in biological pathway construction and analysis. PLoS Comput Biol. 2008 Feb;4(2):e16. Review.

Gonzalez-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, and Sealfon SC. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008. Mar 6;452(7183): p. 93-7.

Ruf F, Hayot F, Park MJ, Ge Y, Lin G, Roysam B, and Sealfon SC. Noise propagation and scaling in regulation of gonadotrope biosynthesis. Biophys J, 2007. Dec 15;93(12): p. 4474-80.

Viswanathan GA, Nudelman G, Patil S, and Sealfon SC. BioPP: a tool for web-publication of biological networks. BMC Bioinformatics., 2007. May 22;8: p. 168.

Gonzalez-Maeso J, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, Lira A, Bradley-Moore M, Ge Y, Zhou Q, Sealfon SC and Gingrich JA. Hallucinogens recruit specific cortical 5-HT (2A) receptor-mediated signaling pathways to affect behavior. Neuron, 2007. Feb 1;53(3): p. 439-52.

Ruf F, Park MJ, Hayot F, Lin G, Roysam B, Ge Y, and Sealfon SC. Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone. J Biol Chem, 2006. Oct 13;281(41): p. 30967-78.