The research of our lab is focused on adeno-associated virus (AAV), a promising gene therapy vector. One area of our research aims at gaining a better understanding of the cellular roadblocks that prevent the efficient transduction of certain cell types by AAV.
Because for many gene therapy applications the transduction of only specific cell types and tissues is required, a second area of research of our lab is the development of AAV variants that efficiently transduce specific tissues and cell types—in particular, cell types of the cardiovascular system and stem cells.
The Cardiovascular Research Center at Mount Sinai recruited Thomas Weber, PhD, in 2008 for his expertise in the biology of adeno-associated vector entry. Research projects Dr. Weber currently leads include:
Thomas Weber, PhD
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