Recent Publications

1. Guo Y, Zi X, Koontz Z, Kim A, Xie J, Gorlick R, Holcombe RF, Hoang BH. Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma SAOS-2 cells. J Orthopaedic Research, 25:964-971, 2007 [Feb 22, Epub ahead of print]. PMID:17318900 

2. Planutis K, Planutiene M, Moyer MP, Nguyen A, Perez C, Holcombe RF. Regulation of norrin receptor frizzled 4 by Wnt2 in colon-derived cells: Evidence for cross-talk between colon cancer and normal colonic mucosa. BMC Cell Biology 8:12-21, 2007. PMID:17386109. PMCID:PMC1847812 

3. You XJ, Bryant PJ, Jurnak F, Holcombe RF. Expression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel disease. Oncology Reports 18:691-694, 2007. PMID:17671721 

4. Zell JA, McEligot AJ, Ziogas A, Holcombe RF, Anton-Culver H. Differential effects of wine consumption on colorectal cancer outcomes based on family history of the disease. Nutrition and Cancer: An International Journal 59:36-45, 2007. (co-senior author) PMID:17927500 [CO-SENIOR AUTHOR ON THIS MANUSCRIPT.] 

5. You XJ, Nguyen AV, Albers G, Lin F, Holcombe RF. Wnt pathway-related gene expression in inflammatory bowel disease. Digestive Diseases & Sciences 53:1013-1019, 2008. [October 16, 2007 - Epub ahead of print]. PMID:17939044 

6. Gatcliffe TA, Monk BJ, Planutis, K, Holcombe RF. Wnt signaling in ovarian tumorigenesis. International J Gynecol Cancer 18:954-962, 2008. [November 6, 2007 - Epub ahead of print]. PMID:17986238. PMCID: PMC2575063. 

7. Chang KJ, Lee JG, Holcombe RF, Kuo J, Muthusamy M, Wu M. Endoscopic ultrasound delivery of an anti-tumor agent to treat a case of pancreatic cancer. Nature Clinical Practice: Gastroenterology & Hepatology, 5:107-111, 2008. PMID:18253139 

8. Hope C, Planutis K, Planoutiene M, Moyer MP, Johal KS, Woo J, Santoso C, Hanson JA, Holcombe RF. Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: Implications for colon cancer prevention. Molecular Nutrition and Food Research 52 Suppl 1:S52-61, 2008. PMID: 18504708. PMCID: PMC2519107 

9. Tang Y, Simoneau AR, Liao W-X, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Molecular Cancer Therapeutics 8:458-468, 2009. [January 27, 2009 – Epub ahead of print]. PMID: 19174556. PMCID: PMC2768341. 

10. Nguyen AV, Martinez M, Stamos MJ, Moyer MP, Planutis K, Hope C, Holcombe RF. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Management & Research 1:25-37, 2009. 

11. Najdi R, Syed A, Arce L, Theisen H, Ting J-H, Atcha F, Nguyen AV, Martinez M, Holcombe RF, Edwards RA, Marsh JL, Waterman ML. Wnt-directed changes in nuclear export and gene expression alter TCF function in colon cancer. Oncogene 28:4133-46, 2009. [September 14, 2009 - Epub ahead of print]. PMID: 19749792. PMCID: PMC2787979. [ONLY TRANSLATIONAL SCIENTIST INVOLVED IN THIS RESEARCH. OBTAINED NORMAL, POLYP AND MALIGNANT TISSUE FOR ANALYSIS UNDER INDIVIDUAL IRB-APPROVED PROTOCOL. PERFORMED ANALYSIS OF TCF1 EXPRESSION BY QRT-PCR IN POLYP TISSUES. KEY CONTRIBUTOR TO DATA ANALYSIS AND MANUSCRIPT PREPARATION.] 

12. Nguyen AV, Albers CG, Holcombe RF. Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. International Journal Molecular Medicine 26:121-125, 2010. PMID: 20514431. 13. Planutiene M, Planutis K, Holcombe RF. LEF1 is upregulated by Wnt3a in endothelial cells and promotes endothelial cell proliferation, invasion and matrix metalloproteinase-2 expression. BMC Cell Biology 2010, submitted.