Publications

The following list contains selected peer-reviewed publications from Yue Laboratory (selected from 75 peer-reviewed publications).

Recent publications of importance to the field (in chronological order):

Yue Z and Yang XW (2013) Dangerous duet: LRRK2 and alpha-synuclein jam at CMA. Nature Neuroscience. 2013 Apr;16(4):375-7. doi: 10.1038/nn.3361. PMID: 23528933

Yang Y, Coleman M, Zhang L, Zheng X, Yue Z (2013). Autophagy in axonal and dendritic degeneration. Trends in Neuroscience. 2013 Apr 29. doi:pii: S0166-2236(13)00062-3. PMID: 23639383.

Bezard E, Yue Z, Kirik D, Spillantini MG (2013). Animal Models of Parkinson Disease: limits and relevance to neuroprotection studies. Movement Disorders 28(1):61-70.

Konishi A, Arakawa S, Yue Z, Shimizu S. (2012) Involvement of Beclin 1 in the engulfment of apoptotic cells. The Journal of Biological Chemistry; Mar 5. PMID: 22393062.

Friedman L, Lachenmayer L, Wang J, He L, Poulose S, Komatsu M, Holstein G, Yue Z. (2012) Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of a-synuclein and LRRK2 in the brain. The Journal of Neuroscience 2012 May 30;32(22):7585-93. PMID: 22649237.

McMahon J, Huang X, Yang J, Komatsu M, Yue Z, Qian J, Zhu X, Huang Y. (2012) Impaired autophagy in neurons following disinhibition of mTOR and its contribution to epileptogenesis. Journal of Neuroscience Nov 7;32(45):15704-14.

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S. (2012) Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry. 2012 Jul 31. [Epub ahead of print]. PMID: 22850627.

Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S. (2012) Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry. 2012 Aug 7. [Epub ahead of print] PMID: 2286903.

Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, Lachenmayer ML, Yue Z, Ehrlich ME, Petsko G, Ju S, Ringe D, Sankovich SE, Caine JM, Macreadie IG, Gandy S, Martins RN. (2012) Latrepirdine (Dimebon™) Enhances Autophagy and Reduces Intracellular GFP-Aβ42 Levels in Yeast. J Alzheimers Dis. 2012 Aug 17. [Epub ahead of print] PMID: 22903131.

Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M, Yue Z*, Zhao Y*. (2012) Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nature Communications; Feb 7;3:662. PMID: 22314358. *Co-corresponding authors.

Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. (2012) Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation. Cell Host & Microbe; 11(3):264-76. PMID: 22423966.

Hernández-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, Yue Z, Czaja MJ, Friedman SL. (2012) Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology; 142(4):938-46. PMID: 22240484.

Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP. (2011) Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice. PLoS Genetics; 7(10):e1002321. PMID: 22022281.

Morris S, Swanson MS, Lieberman A, Reed M, Yue Z, Lindell DM, Lukacs NW. (2011) Autophagy-mediated dendritic cell activation is essential for innate cytokine production and APC function with respiratory syncytial virus responses. The Journal of Immunology; 187(8):3953-61. PMID: 21911604.

Suárez AL, Kong R, George T, He L, Yue Z, van Dyk LF. (2011) Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistence. Journal of Virology; 85(13):6293-308. PMID: 21490089.

Li X, Wang QJ, Pan N, Lee S, Zhao Y, Chait BT, Yue Z. (2011) Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS One; 6(3):e17153. PMID: 21390248.

Arsov I, Adebayo A, Kucerova-Levisohn M, Haye J, Macneil M, Papavasiliou FN, Yue Z, Ortiz BD. (2011) A role for autophagic protein beclin 1 early in lymphocyte development. The Journal of Immunology; 186(4):2201-9. PMID: 21239722.

Dou Z, Chattopadhyay M, Pan JA, Guerriero JL, Jiang YP, Ballou LM, Yue Z, Lin RZ, Zong WX. (2010) The Class IA phosphatidylinositol 3-kinase p110ß subunit is a positive regulator of autophagy. The Journal of Biological Chemistry; 15;191(4):827-43. PMID: 21059846.

Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z. (2010) Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. The Journal of Neuroscience; 30(5):1788-97. PMID: 20130188.

Zhong Y, Wang QJ, Li X, Chait BT, Heintz N, and Yue Z. (2009) Distinct Regulation of Autophagic Activity by Novel Components Atg14L and Rubicon in Beclin 1-Vps34/phosphatidylinositol (PtdIns) 3-kinase complex. Nature Cell Biology; 11(4):468-76, PMID: 19270693.

Arsov I, Li X, Matthews G, Coradin J, Hartmann B, Simon AK, Sealfon SC, Yue Z. (2008) BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death and Differerentiation;15(9):1385-95. PMID: 18451870.

Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, Goldman JE. (2008) Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Human Molecular Genetics; 17(11):1540-55. PMID: 18276609.

Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K. (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell; 131 (6):1149-63, PMID: 1808310.

Ullman E, Fan Y, Stawowczyk M, Chen HM, Yue Z, Zong WX. (2007) Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death and Differentiation; 2008 Feb;15(2):422-5. PMID: 17917679.

Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K, Yue Z. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proceedings of the National Academy of Sciences USA; 104 (36): 14489-14494, PMID: 17726112.

Wang QJ, Ding Y, Kolhz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z. (2006) Induction of autophagy in axonal dystrophy and degeneration. The Journal of Neuroscience; 26(31):8057-8068, PMID: 16885219.

Yue Z, Jin S, Yang C, Levine AJ, Heintz N. (2003) Beclin1, an autophagy gene essential for early embryonic development, is a haplo-insufficient tumor suppressor. Proceedings of the National Academy of Sciences USA; 100 (25):15077-15082, PMID: 14657337.

Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N. (2002) A Novel Protein Complex linking the d2 Glutamate Receptor (GluRd2) and Autophagy: Implications for Neurodegeneration in Lurcher Mice. Neuron; 35 (5):921-33 PMID: 12372286.