Research Support

Current

Targeted Inhibition of Inducible Nitric Oxide Synthase (iNOS) to Enhance Sensitivity of Head and Neck Squamous Cell Carcinoma to Cisplatin-Based Therapy
Purpose:
The major goal of this project is to determine the feasibility of pharmacologic inhibition of inducible nitric oxide synthase (iNOS) in combination with chemotherapy as a treatment for head and neck cancer.
Type: NIH Clinical Research Loan Repayment Program (LRP)
Agency: NIH
Investigator: Andrew Sikora, MD/PhD (PI)
Term: 10/2010 - 03/2013

Role of Activated EGFR and COX-2 in Metastasis and Escape from Tumor Dormancy
Purpose:
The goal of this project is to test the hypothesis inhibition of inflammatory signaling through the COX-2 and iNOS pathways in combination with inhibition of EGFR signaling will prevent dissemination and growth of head and neck cancer cells in a mouse model.
Type: R03DE021741-01A1
Agency: National Institute of Dental and Craniofacial Research, NIH
Investigator: Andrew Sikora, MD/PhD (PI); Julio Aguirre-Ghiso, PhD (Co-I)
Term: 9/2011 - 6/2013

Spousal Support and Emotional Disclosure in Head and Neck Cancer
Purpose:
Specific aims are to: (1) examine the associations between patients’/spouses reported/observed communication behaviors and their cognitive processing; (2) examine associations between couples’ communication styles at the initiation of treatment and patient and spouse psychological functioning and general QOL 4 months after treatment; and, (3) to examine associations between patient symptom distress, patient disclosure, and patient cognitive processing over the course of radiation treatment for HNC
Type: K07CA124668-01A2
Agency: NIH/NCI
Investigator: Hoda Badr, PhD
Term: 09/2013

Improving Oral Health and Quality of Life After Oral Cancer: A Web-based Approach
Purpose:
This study proposes a web-based intervention, called Computer Assisted oral health REhabilitation and Support (CARES), which is guided by Self Determination Theory (SDT). Specific aims are: 1a) To develop and evaluate the content of the CARES intervention; 1b) To evaluate the feasibility of the CARES prototype; and 2) To pilot test the initial efficacy of CARES.
Type: R34 DE022273
Agency: NIH/NIDCR
Investigator: Hoda Badr, PhD
Term: 09/2013

Couple-focused Symptom Management Intervention for Older Lung Cancer Patients and their Spouses
Purpose:
This is a pilot study grant funded through the Claude D. Pepper Older American Independence Centers (OAIC) – ‘Promoting Independence through Pain and Symptom Management,’ Center grant. Specific aims of this mentored pilot study are to: 1) use in-depth interviews to develop and refine a couple-focused intervention for older lung cancer patients and their partners; and, 2) to pilot test the intervention in a small randomized trial.
Type: NIA P30 AG028741-01A2
Agency: OAIC
Investigator: Albert Siu, MD; Hoda Badr, PhD
Term: 2013

Optical Systems for in vivo Molecular Imaging of Cancer
Purpose:
The major goal of this project is to develop new contrast agents and optimize micro-endoscopic evaluation to discriminate benign from cancerous tissue in the upper aerodigestive tract and other sites.
Type: 2R01 CA103830-06 (Renewal)
Agency: National Cancer Institute, NIH
Investigator: Andrew Sikora, MD/PhD (Co-PI)
Term: 05/2011 - 04/2014

Functional Determinants of Metastatic Dormancy
Purpose:
To study the role of p53, BHLHB3 and ATF6 signaling pathways in the induction of dormancy and survival of dormant disseminated tumor cells in the bone marrow. Also, to isolate and functionally characterize bone marrow disseminated tumor cells in different target organs.
Type: RO1CA109182
Agency: NYSTEM – ESSCB
Investigator: Julio Aguirre-Ghiso, PhD (PI)
Term: 07/01/2004 - 12/31/2014

Regulation by p38 and NR2F1 Signaling of Early Dissemination and Dormancy of Breast Cancer Cells
Purpose:
To study the role of NR2F1 and p38 signaling in the regulation of an epithelium to mesenchyme transition and early dissemination from pre-malignant mammary epithelium that is HER2 positive.
Type: BC112380
Agency:
Investigator: Maria Soledad Sosa, PhD (PI), Julio Aguirre-Ghiso, PhD (Mentor)
Term: 2012 - 2015

Targeting iNOS to Inhibit Myeloid-Derived Suppressor Cells (MDSC) in Melanoma
Purpose:
The goal of this project is to determine the role of inducible nitric oxide synthase (iNOS) in the induction of immunosuppressive myeloid-cells, and to test the ability of pharmacologic iNOS inhibition to reverse cancer-associated immunosuppression.
Type: K08 CA154963 Career Development Award
Agency: National Cancer Institute, NIH
Investigator: Andrew Sikora, MD/PhD (PI)
Term: 6/2011 - 5/2016

Tumor Microenvironments Determining Migration, Dissemination, and Dormancy (TMEN, U54)
Purpose:
The major research focus of our proposed TMEN Center is the study of the microenvironments in primary tumors that drive tumor cell dissemination and survival, and dormancy and growth at secondary organs
Type: U54CA163131
Agency: NIH/NCI
Investigator: Julio Aguirre-Ghiso, PhD (PI)
Term: 09/01/2011 - 08/31/2016

Past:

Methods of Treating Head and Neck Squamous Cell Carcinoma Residual Disease
Purpose:
To perform a pre-clinical testing of small molecules that disrupt uPAR-integrin-EGFR signaling in HNSCC.
Type: Collaborative grant
Agency: MSSM: Technology Development Fund Award
Investigator: Julio Aguirre-Ghiso, PhD (PI)
Term: 01/2011 - 01/2012

Characterization of the Endogenous Immune Response in HPV+ Oropharyngeal Squamous Cell Carcinoma Patients Receiving Radiation-Based Therapy
Purpose:
The major goal of this project is to examine the HPV-specific immune response in patients with HPV+ and HPV- oropharyngeal cancer before and after radiation-based therapy.
Type: MSSM Tisch Cancer Center Developmental Award
Agency: MSSM
Investigator: Andrew Sikora, MD/PhD (Co-PI), Seunghee Kim-Schulze, PhD (Co-I)
Term: 01/2011 - 3/2012

Regulation of Disseminated Tumor Cell Fate by RAR and NR2F1 Signaling
Purpose:
To study the role of RAR and NR2F1 to the dormancy of disseminated tumor cells to the bone marrow and lung in HNSCC and breast cancer models.
Type: Collaborative grant
Agency: Samuel Waxman Cancer Research Foundation
Investigator: Julio Aguirre-Ghiso, PhD (Co-I)
Term: 06/2009 - 07/2012

Plasticity of Head and Neck Cancer Initiating Cells
Purpose:
To identify tumor initiating “stem” cells in HNSCC and determine whether their behavior follows a stochastic or hierarchical model. Also , to identify the underlying mechanisms driving tumor initiating cell behavior and its link to cancer dormancy.
Type: Investigator-initiated research project
Agency: NIH/NCI
Investigator: Julio Aguirre-Ghiso, PhD (PI)
Term: 01/01/2009 - 12/31/2012

Self-Determination Theory and Lifestyle Behaviors in Barrett's Esophagus Patients
Purpose:
Specific aims are to: (1) characterize the lifestyle behaviors (e.g., diet, physical activity [PA], smoking, alcohol use) of BE patients from baseline to 6 months later; and, to evaluate a Self-Determination Theory process model for patient lifestyle change during the same time frame; and (2) to determine the effects of spousal autonomy support at baseline on patients’ autonomous motivation and perceived competence to engage in recommended lifestyle changes (i.e., to eat a healthier diet, engage in more PA, achieve a healthy body weight, and stop smoking and drinking alcohol) at baseline and 3 and 6 months later.
Type: R03CA136056-01
Agency: NIH/NCI
Investigator: Hoda Badr, PhD
Term: 09/2012

EBV-Specific T-Cell Therapy for Nasopharynx Cancer: Immunomodulation and Response
Purpose:
To perform a Phase II adoptive immunotherapy trial in incurable NPC and study immunologic correlates of response
Type: R21 CA132279
Agency: NCI/NIH, Dana-Farber Cancer Institute Administered
Investigator: Marshall Posner, MD (PI)
Term: 09/26/2008 - 2012


Contact Us

Andrew Sikora, MD, PhD
Director, Head and Neck Translational Research
Tel: 212-659-9516
Send e-mail

Julio Aguirre-Ghiso, PhD
Director, Head and Neck Cancer Basic Research
Tel: 212-241-9582
Send e-mail

Mariko Stronach
Research Program Coordinator
Tel: 212-241-9144
Send e-mail