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Milestones and Firsts by Elliot and Roslyn Jaffe Food Allergy Institute Researchers*
The Jaffe Food Allergy Institute at Mount Sinai in New York City is one of the world’s leaders in food allergy research. Today many children and adults are living longer, healthier lives because of the outstanding accomplishments and important insights of Jaffe researchers and the expert care they receive here for a broad spectrum of allergic problems and immunologic disorders.
Here are just a few of the Jaffe Institute’s milestones.
Epidemiology and Clinical Manifestations of Allergy
- Identification of risk factors for anaphylaxis, a severe, potentially fatal allergic reaction
- Described aspects of the natural course of egg, milk and peanut allergies
- Found that peanut allergies have more than tripled in children in the U.S. since the late 1990s
- Discovered that food allergy is a cause of eosinophilic esophagitis (an inflammation of the esophagus)
- Characterized and coined the term “Food Protein Induced Enterocolitis Syndrome” (FPIES), a non-IgE-mediated gastrointestinal food allergy disorder
- Used double-blind, placebo-controlled food challenges to determine the role of food allergy in atopic dermatitis
- Identified the relationship of blood test results to food allergy outcomes to improve diagnosis, now used worldwide
- Identified important components of multiple allergens for improving diagnoses
- Determined that baked forms of milk or egg may be tolerated by a majority with those allergies and ingestion may speed the resolution of these allergies
- Conducted studies of novel therapies using ingredients from traditional Chinese medicine
- Developed a novel food allergy vaccine using mutated proteins
- Conducted the first placebo- controlled study of egg oral immunotherapy
- Conducted the first placebo-controlled trial of dual therapy (immunotherapy and anti-IgE)
- Conducted the first placebo-controlled trial of anti-IgE for food allergy (a form of treatment for allergic conditions)
- Developed the first validated, publically-accessible educational program for managing childhood food allergies
- Conducted studies emphasizing the impact of food allergies on quality of life and bullying
Advocacy and Legislation
- Conducted multiple studies that paved the way for improved food labeling
*Many of these milestones were performed in collaboration with national and international colleagues.
With your continued support as participants in our research and with your generous donations to our work we can achieve great things!
Jaffe Food Allergy Institute
5 East 98th Street, 10th Floor
New York, NY 10029
Fall 2013 [PDF]