Data Sharing Plan

This program focuses on mechanisms involved in p53 regulation and functions from novel perspectives elucidated by our investigators. The overall long term objectives of this research are to develop understanding of mechanisms by which p53 integrates responses to cellular stresses ranging from severe hypoxia and inflammation to the effects of genotoxic agents including many cancer therapeutics in determining cell fate decisions.

Data sets from this study including molecular, biochemical, and structural biological data will be made available without cost to researchers and analysts. The final data set will include both raw data and derived variables, which would be described in the documentation associated with the data set. The nature and format of the data will be computerized in final form. To ensure the access of all registered users PDF files will be created in Adobe Acrobat version 5.0 or higher. Typically, data sets will be available after acceptance for publication of the main findings from the final data set. User registration will be required in order to access or download files. 

Eligible users shall be defined as academic researchers and trainees involved in basic, translational or clinical research in cancer. As part of the registration process, users are required to submit their title, name of institution, area of research, and NIH bio-sketch. Registered users must agree to the conditions of use governing access to the public release data, including reporting responsibilities, restrictions on redistribution of the data to third parties, and proper acknowledgement of the data resource. Registered users may receive user support, as well as information related to errors in the data, future releases, and publication lists. The information provided to users shall not be used for commercial purposes, and will not be redistributed to third parties.

The Administrative Core will continue to maintain the Web site to allow registered users to have access to final data sets for a period of three years beyond the end of the grant.