Manganese 2016 Conference

Manganese Health Effects on Neurodevelopment and Neurodegenerative Diseases
September 25-28, 2016
New York City

Click here to access the webcast.

Conference Materials


On September 25-28, 2016, the Icahn School of Medicine at Mount Sinai hosted MANGANESE2016, an international conference on the neurotoxicity and prevention of adverse manganese health effects. This was the 28th meeting in the International Neurotoxicology Conference series, and the first time a meeting in the conference series was convened at Mount Sinai. 

MANGANESE2016 was attended by more than 150 representatives from academia, government, industry, and labor from 19 countries, including Belgium, Brazil, Canada, China, Costa Rica, France, Germany, Italy, Mexico, Mongolia, Morocco, Netherlands, Norway, Norway, South Africa, South Korea, Sweden, the United Kingdom, and the United States. More than 300 individuals registered for the live online webcast and there were 200 active viewers.

The conference was chaired by Roberto Lucchini, MD, Director, Division of Occupational and Environmental Medicine, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai. Additional participants from Environmental Medicine and Public Health included Department Chair Robert O. Wright, MD, MPH; Manish Arora, BDS, MPH, PhD; Mathilda Chiu, ScD; Philip J. Landrigan, MD, MSc; and Megan Horton, PhD, MPH.

International experts and new researchers gathered to present, discuss, and evaluate the most recent information on manganese. The conference yielded state-of-the-science discussion of what is known and identified information gaps. A summary report is in development to identify needs for future research. The peer-reviewed proceedings will be published as a Special Issue of the international journal NeuroToxicology.  Special highlights included a poster competition to encourage young investigators working in the area of manganese exposure research and an awards banquet honoring Annette Kirschner, PhD, who retired this year after 28 years of service at the National Institute of Environmental Health Sciences.  Poster competition winners are noted below.

Support for the conference was provided by the National Institute of Environmental Health Sciences, the Environmental Protection Agency, the National Institute of Neurological Disorders and Stroke, International Manganese Institute, International Commission on Occupational Health, Society of Toxicology, Drs. Morris and Joan Cranmer, the Centre national du cinema (Paris), and the Royal Society of Chemistry.

Post-doctoral Poster competition winners

1st Place: Kalynda Gonzales, PhD, Postdoctoral Associate in Environmental and Occupational Health, Florida International University

“Loss of striatal cholinergic interneurons in the presence of intact nigral dopaminergic neurons in early manganese-induced parkinsonism”

2nd Place: Anna Pfalzer, PhD, Postdoctoral Fellow in Pediatric Neurology at Vanderbilt University

“Manganese-induced alterations of the striatal transcriptome in Huntington’s disease mice”

3rd Place: Christopher Barnhart, PhD, Postdoctoral Fellow in Molecular Pharmacology at the Albert Einstein College of Medicine

“The role of TMEM135 in manganese-induced death and neurodegeneration in C. elegans and primary dopaminergic cultures”

Pre-doctoral Poster competition winners

1st Place: Miles Bryan, Pediatrics, Biochemistry, Neurology, Vanderbilt University

“A potential role for phosphotidyl -inositol-3-kinase (PI3K) in regulating manganese homeostasis through an autophagy-mediated mechanism”

2nd Place: Katriana Popichak, Department of Environmental and Radiological Health Sciences, Colorado State University

“Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese”

3rd Place: David Edmondson, School of Health Sciences, Purdue University

“Reversibility of increased thalamic GABA levels in welders with decreased Mn exposure”

Honorable Mention:  Rebecca Bailey, Neurology, Cincinnati Children’s Hospital Medical Center

“Additive effects of developmental manganese overexposure in combination with 6-OHDA toxicity on egocentric and allocentric learning and memory”