Adolfo Garcia Ocana, PhD
- PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
Research Topics:
Apoptosis/Cell Death, Cell Biology, Cell Cycle, Cell Division, Diabetes, Gene Expressions, Gene Regulation, Gene Therapy, Growth Factors and Receptors, Hormones, Knockout Mice, Molecular Biology, Obesity, Protein Kinases, Receptors, Signal Transduction, Transcription Factors, Transgenic Mice, TransplantationDr. Garcia-Ocaña’s research interest over the years has been to study tissue regeneration, growth promoting agents and intracellular signaling. More specifically, his research group is currently working in three areas of research: First, his research group is studying the role of agents that can induce robust pancreatic beta cell regeneration in vivo using mouse models of human islet transplantation. In collaboration with Drs. Andrew Stewart, Peng Wang and Robert DeVita, his group is testing the effect of harmine and harmine derivatives on human beta cell expansion in mice transplanted with human islets using 3D imaging techniques. These studies could have strong implications for future therapies aiming at increasing the number of insulin-producing cells in diabetic patients. Second, since beta cell regenerative therapies will require, at the same time, treatment with pancreatic beta cell protective agents and immune tolerance enhancers for type 1 diabetes therapy, his research group is also studying sulfated polysaccharides and growth factors that simultaneously modulate the immune system and protect pancreatic beta cells for amelioration of type 1 diabetes. Third, his lab, in collaboration with Dr. Donald Scott group, is studying how pancreatic beta cells adapt to changes in nutrients and the role that the transcription factor Myc plays in this adaptation. His research group is using the latest technologies (HTS, Genomics, Proteomics and Metabolomics), animal models and basic science knowledge to uncover and translate significant findings into potential safe and innovative therapies for the treatment of diabetes. Additional information regarding Dr. Garcia-Ocaña’s research group, funding and publications can be found clicking the following link: https://labs.icahn.mssm.edu/garciaocana-lab/.
Dr. Garcia-Ocaña is also the Director of the Human islet and Adenovirus Core (HIAC) funded by the joint Albert Einstein-Mount Sinai Diabetes Research Center (ES-DRC). The HIAC provides key advice, methods, technology and infrastructure to assist research investigators in the use of human islets for research, with the goal of furthering understanding of normal and pathophysiologic islet cell growth and function. While the focus is on human islets, the HIAC also provides isolation of rodent islets, access to rodent insulinoma cell lines, and specific experimental analyses such as assays for insulin secretion, islet bioenergetics, beta cell proliferation, mass and survival, as well as human islet transplantation into immunodeficient mice, with subsequent functional analyses. HIAC also generates and makes available to the ES-DRC community reagents and tools including adenovirus or lentivirus viralvectors for gene delivery of cDNAs and shRNAs of interest to beta cells and other cell types to study beta cell regeneration, differentiation, survival and function. For more information, please click the following link: https://einsteinmed.org/centers/diabetes-research/human-Islet-and-adenovirus-core/.
Education
BS, Universidad Autonoma of Madrid
PhD, Universidad Autonoma of Madrid
PhD Student, Université Paris VII, Dept. of Renal Physiology, Faculté de Medecine Xavier Bichat
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Garcia Ocana during 2021 and/or 2022. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting:
- Sun Pharmaceuticals
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.