Aurelian Radu, PhD
- ASSOCIATE PROFESSOR | Cell, Developmental & Regenerative Biology
Research Topics:Angiogenesis, Anti-Tumor Therapy, Cancer, Endothelial Cells
National Diploma Physics and Biophysics, University of Bucharest
PhD, Institute of Cellular Biology and Pathology
FSHR as a marker of tumor blood vessels
My research work is focused on a marker of tumor blood vessels, the Follicle Stimulating Hormone Receptor (FSHR), which is present in all major tumor types that we investigated, while having a very limited presence in normal tissues and organs.
We are evaluating the feasibility of FSHR blood tests, to detect the presence of tumors and to monitor their response to therapies based on FSHR released in blood. We are also working to elucidate the role of FSHR in cancer progression. Another area of investigation is the use of FSHR as a target for directing imaging and therapeutic agents into tumors.
Radu A, Pichon C, Camparo P, Antoine M, Allory Y, Couvelard A, Fromont G, Vu Hai M, Ghinea N. Blood vessel endothelium expresses FSHR in a wide range of human cancers . New Engl J Med 2010 Oct; 363(17): 1621-1630.
Siraj MA, Pichon C, Radu A, Ghinea N. Endothelial FSH receptor in primary kidney cancer correlates with subsequent response to Sunitinib. J Cell Mol Med 2012; 16(9): 2010-16.
Siraj MA, Desestret V, Antoine M, Fromont G, Huerre M, Sanson M, Camparo P, Pichon C, Planeix F, Gonin J, Radu A, Ghinea N. Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases.. BMC Cancer. 2013; 13: 246-252.