Bachir Taouli, MD
- PROFESSOR | Radiology
- PROFESSOR | Medicine
Specialties:Radiology, Body Imaging
Research Topics:Cancer, Eye Movements, Liver, Magnetic Resonance Imaging, Mathematical Modeling of Biomedical Systems
Bachir Taouli, MD, MS, is Professor of Radiology and Medicine in the Body Imaging Section (Department of Radiology) and the Translational and Molecular Imaging Institute (TMII) at the Icahn School of Medicine at Mount Sinai, New York. After completing medical school and Radiology Residency in Paris VI University (France) in 2000, he joined the UCSF Department of Radiology for a research fellowship and post-doctoral clinical training. He then joined the NYU Department of Radiology where he worked for 6 years and where he developed clinical applications of advanced MRI techniques applied to liver, kidney and prostate diseases, including diffusion and perfusion imaging and spectroscopy. He joined the Icahn School of Medicine at Mount Sinai in 2009, where he is currently the director of Body MRI and Cancer Imaging in the Department of Radiology and TMII. Dr Taouli has been named vice-chair for translational research in April 2017. Dr. Taouli is a clinician scientist with particular expertise in the application of advanced MRI sequences applied to diffuse liver disease/liver cancer and abdominal and pelvic malignancies, including prostate cancer. He directs the Body MRI quantitative group at TMII (https://tmii.mssm.edu/research/research-laboratories/taouli-lab/). Dr. Taouli has extensive experience in Body MRI, and has been successfully NIH funded since 2010. He has authored/co-authored over 164 peer-reviewed manuscripts and book chapters primarily on body MRI, and lectured throughout the world on advanced body MRI techniques. Finally, Dr Taouli is a member of several scientific societies, including the Radiological Society of North America (RSNA), the International Society of Magnetic Resonance in Medicine (ISMRM), the American Roentgen Ray Society (ARRS), the Society of Abdominal Radiology (SAR), the European Society of Radiology (ESR), the American Association for the Study of Liver Diseases (AASLD), and the European Society of Gastrointestinal and Abdominal Radiology (ESGAR). He is a previous Associate editor for the American Journal of Roentgenology, previous member of the Annual Meeting Program Committee of the ISMRM, and the RSNA Gastrointestinal Radiology Subcommittee.
- CT Scan Of The Abdomen
- Diagnostic Ultrasound Of The Abdomen
- Inflammatory Bowel Disease
- Magnetic Resonance Imaging
- Upper Gastrointestinal Series
Multi-Disciplinary Training AreaBiophysics and Systems Pharmacology [BSP]
MD, Universite D' Alger
Residency, Pediatrics, Universite D' Alger
Residency, Diagnostic Imaging, Paris VI University (France)
Fellowship, Radiology, University of California - San Francisco
Best Translational Research/Dose Scientific Paper Award for abstract
Magna Cum Laude Merit Award for abstract
Magna Cum Laude Merit Award for abstract
Summa Cum Laude Merit Award
Fellow of the Society of Abdominal Radiology
Magna Cum Laude Merit Award
Best Paper-First time presenter
Non invasive detection of liver fibrosis and cirrhosis with MRI
MRI is a versatile technique, with no radiation exposure, and the possibility of performing multiparametric imaging. One of the interesting applications of MRI is the non invasive detection of liver damage caused by hepatitis and other insults, usually assessed with liver biopsy. Dr Taouli's experience using diffusion and perfusion MRI showed potential usefulness for detection of liver fibrosis and cirrhosis. MR elastography is also an emerging technique that will soon be offered routinely to patients with liver disease at Mount Sinai.
Assessment of liver cancer with advanced MRI methods
Primary liver cancer (hepatocellular carcinoma: HCC) can be treated aggressively when diagnosed early, using for example hepatic resection of transplantation. Imaging plays a pivotal role in the detection of hepatocellular carcinoma. MRI is especially attractive as it is radiation free and can be easily repeated in patients with liver disease on a regular basis. One of Dr Taouli's research interests is to characterize liver tumors in terms of aggressiveness, angiogenesis and oxygen delivery through the use of advanced MRI methods.
HCC screening using abbreviated MRI
An abbreviated MRI protocol (less than 15 min acquisition time) using a liver specific agent such as gadoxetic acid has the potential to improve liver cancer detection compared to standard ultrasound. We have started a prospective research protocol comparing the abbreviated MRI to ultrasound for HCC screening in patients with cirrhosis.
Prediction of the degree of portal hypertension in patients with cirrhosis
The goal of this study is to develop non invasive tools based on MR elastography and phase-contrast 4D flow imaging of the liver and spleen as biomarkers of portal pressure in patients with chronic liver disease.
Assessment of prostate cancer with MRI
MRI is the primary modality used for prostate cancer detection and staging. One of Dr Taouli's research interests is the use of multiparametric MRI to better detect and stage prostate cancer, and assess and predict response to radiation therapy.
Radiogenomics of HCC using qualitative and quantitative MRI
The goal of this study is to develop and validate robust and reproducible qualitative and quantitative MRI-signatures of genomic aberrations of HCC, and that ultimately predict response to molecular targeted therapies, enabling personalized management of HCC patients.
Chandarana H, Robinson E, Hajdu CH, Drozhinin L, Babb JS, Taouli B. Microvascular invasion in hepatocellular carcinoma: is it predictable with pretransplant MRI?. AJR. American journal of roentgenology 2011 May; 196(5).
Chandarana H, Lee VS, Hecht E, Taouli B, Sigmund EE, Taouli B. Comparison of biexponential and monoexponential model of diffusion weighted imaging in evaluation of renal lesions: preliminary experience. Investigative radiology 2011 May; 46(5).
Rosenkrantz AB, Oei M, Babb JS, Niver BE, Taouli B. Diffusion-weighted imaging of the abdomen at 3.0 Tesla: image quality and apparent diffusion coefficient reproducibility compared with 1.5 Tesla. Journal of magnetic resonance imaging : JMRI 2011 Jan; 33(1).
Do RK, Chandarana H, Chandanara H, Felker E, Hajdu CH, Babb JS, Kim D, Taouli B. Diagnosis of liver fibrosis and cirrhosis with diffusion-weighted imaging: value of normalized apparent diffusion coefficient using the spleen as reference organ. AJR. American journal of roentgenology 2010 Sep; 195(3).
Merkle EM, Szklaruk J, Taouli B, Felker E, Hajdu CH, Babb JS, Kim D, Taouli B. Imaging techniques in the diagnosis of hepatocellular carcinoma and metastatic carcinoma as a result of colon cancer. Gastroenterology & hepatology 2010 Aug; 6(8).
Marien T, Taouli B, Telegrafi S, Babb J, Lepor H. Optimizing the detection of subclinical inguinal hernias in men undergoing open radical retropubic prostatectomy. BJU international 2010 Nov; 106(10).
Lim RP, Tuvia K, Hajdu CH, Losada M, Gupta R, Parikh T, Babb JS, Taouli B. Quantification of hepatic iron deposition in patients with liver disease: comparison of chemical shift imaging with single-echo T2*-weighted imaging. AJR. American journal of roentgenology 2010 May; 194(5).
Rosenkrantz AB, Kopec M, Kong X, Melamed J, Dakwar G, Babb JS, Taouli B, Taouli B. Prostate cancer vs. post-biopsy hemorrhage: diagnosis with T2- and diffusion-weighted imaging. Journal of magnetic resonance imaging : JMRI 2010 Jun; 31(6).
Rosenkrantz AB, Neil J, Kong X, Melamed J, Babb JS, Taneja S, Taouli B. Prostate Cancer: Comparison of 3D T2-weighted sequence (SPACE) with conventional 2D T2-weighted imaging for Image Quality and Tumor Detection. AJR Am J Roentgenol 2010; In press.
Chandarana H, Robinson E, Hajdu CH, Drozhinin L, Babb JS, Taouli B, Taouli B. Microvascular invasion in hepatocellular carcinoma: is it predictable with pretransplant MRI?. AJR. American journal of roentgenology 2011 May; 196(5).
Gordic S, Corcuera-Solano I, Stueck A, Besa C, Argiriadi P, Guniganti P, King M, Kihira S, Babb J, Thung S, Taouli B. Evaluation of HCC Response to Locoregional Therapy: Validation of MRI-Based Response Criteria versus Explant Pathology. Journal of hepatology 2017 Aug;.
Lo GC, Besa C, King MJ, Kang M, Stueck A, Thung S, Wagner M, Smith AD, Taouli B. Feasibility and reproducibility of liver surface nodularity quantification for the assessment of liver cirrhosis using CT and MRI. European journal of radiology open 2017; 4.
Besa C, Lewis S, Pandharipande PV, Chhatwal J, Kamath A, Cooper N, Knight-Greenfield A, Babb JS, Boffetta P, Padron N, Sirlin CB, Taouli B. Erratum to: Hepatocellular carcinoma detection: diagnostic performance of a simulated abbreviated MRI protocol combining diffusion-weighted and T1-weighted imaging at the delayed phase post gadoxetic acid. Abdominal radiology (New York) 2017 Jul;.
Sagalovich D, Besa C, Tran TY, Thummar H, Le Grand B, Taouli B, Gupta M. Prone Percutaneous Nephrolithotomy: Does Bolster Orientation Matter?. Urology 2017 Jul;.
Lewis S, Besa C, Rosen A, Rastinehad AR, Semann S, Hectors S, Taouli B. Multiparametric magnetic resonance imaging for transition zone prostate cancer: essential findings, limitations, and future directions. Abdominal radiology (New York) 2017 Jul;.
Goossens N, Singal AG, King LY, Andersson KL, Fuchs BC, Besa C, Taouli B, Chung RT, Hoshida Y. Cost-Effectiveness of Risk Score-Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis. Clinical and translational gastroenterology 2017 Jun; 8(6).
Horowitz JM, Venkatesh SK, Ehman RL, Jhaveri K, Kamath P, Ohliger MA, Samir AE, Silva AC, Taouli B, Torbenson MS, Wells ML, Yeh B, Miller FH. Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel. Abdominal radiology (New York) 2017 Aug; 42(8).
Hectors SJ, Wagner M, Bane O, Besa C, Lewis S, Remark R, Chen N, Fiel MI, Zhu H, Gnjatic S, Merad M, Hoshida Y, Taouli B. Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging. Scientific reports 2017 May; 7(1).
Hectors SJ, Wagner M, Corcuera-Solano I, Kang M, Stemmer A, Boss MA, Taouli B. Comparison Between 3-Scan Trace and Diagonal Body Diffusion-Weighted Imaging Acquisitions: A Phantom and Volunteer Study. Tomography : a journal for imaging research 2016 Dec; 2(4).
Taouli B, Hoshida Y, Kakite S, Chen X, Tan PS, Sun X, Kihira S, Kojima K, Toffanin S, Fiel MI, Hirschfield H, Wagner M, Llovet JM. Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results. European radiology 2017 Apr;.
Corcuera-Solano I, Wagner M, Hectors S, Lewis S, Titelbaum N, Stemmer A, Rastinehad A, Tewari A, Taouli B. DWI of the prostate: Comparison of a faster diagonal acquisition to standard three-scan trace acquisition. Journal of magnetic resonance imaging : JMRI 2017 Mar;.
Gordic S, Ayache JB, Kennedy P, Besa C, Wagner M, Bane O, Ehman RL, Kim E, Taouli B. Value of tumor stiffness measured with MR elastography for assessment of response of hepatocellular carcinoma to locoregional therapy. Abdominal radiology (New York) 2017 Jun; 42(6).
Malyarenko DI, Wilmes LJ, Arlinghaus LR, Jacobs MA, Huang W, Helmer KG, Taouli B, Yankeelov TE, Newitt D, Chenevert TL. QIN DAWG Validation of Gradient Nonlinearity Bias Correction Workflow for Quantitative Diffusion-Weighted Imaging in Multicenter Trials. Tomography : a journal for imaging research 2016 Dec; 2(4).
Hectors SJ, Besa C, Wagner M, Jajamovich GH, Haines GK, Lewis S, Tewari A, Rastinehad A, Huang W, Taouli B. DCE-MRI of the prostate using shutter-speed vs. Tofts model for tumor characterization and assessment of aggressiveness. Journal of magnetic resonance imaging : JMRI 2017 Sep; 46(3).
Wagner M, Corcuera-Solano I, Lo G, Esses S, Liao J, Besa C, Chen N, Abraham G, Fung M, Babb JS, Ehman RL, Taouli B. Technical Failure of MR Elastography Examinations of the Liver: Experience from a Large Single-Center Study. Radiology 2017 Aug; 284(2).
Barat M, Fohlen A, Cassinotto C, Jannot AS, Dautry R, Pelage JP, Boudiaf M, Pocard M, Eveno C, Taouli B, Soyer P, Dohan A. One-month apparent diffusion coefficient correlates with response to radiofrequency ablation of hepatocellular carcinoma. Journal of magnetic resonance imaging : JMRI 2017 Jun; 45(6).
Azour L, Besa C, Lewis S, Kamath A, Oliver ER, Taouli B. The gravid uterus: MR imaging and reporting of abnormal placentation. Abdominal radiology (New York) 2016 Dec; 41(12).
Besa C, Lewis S, Pandharipande PV, Chhatwal J, Kamath A, Cooper N, Knight-Greenfield A, Babb JS, Boffetta P, Padron N, Sirlin CB, Taouli B. Hepatocellular carcinoma detection: diagnostic performance of a simulated abbreviated MRI protocol combining diffusion-weighted and T1-weighted imaging at the delayed phase post gadoxetic acid. Abdominal radiology (New York) 2017 Jan; 42(1).
Besa C, Ward S, Cui Y, Jajamovich G, Kim M, Taouli B. Neuroendocrine liver metastases: Value of apparent diffusion coefficient and enhancement ratios for characterization of histopathologic grade. Journal of magnetic resonance imaging : JMRI 2016 Dec; 44(6).
Huang W, Chen Y, Fedorov A, Li X, Jajamovich GH, Malyarenko DI, Aryal MP, LaViolette PS, Oborski MJ, O'Sullivan F, Abramson RG, Jafari-Khouzani K, Afzal A, Tudorica A, Moloney B, Gupta SN, Besa C, Kalpathy-Cramer J, Mountz JM, Laymon CM, Muzi M, Schmainda K, Cao Y, Chenevert TL, Taouli B, Yankeelov TE, Fennessy F, Li X. The Impact of Arterial Input Function Determination Variations on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysis Challenge. Tomography : a journal for imaging research 2016 Mar; 2(1).
Kakite S, Dyvorne HA, Lee KM, Jajamovich GH, Knight-Greenfield A, Taouli B. Hepatocellular carcinoma: IVIM diffusion quantification for prediction of tumor necrosis compared to enhancement ratios. European journal of radiology open 2016; 3.
Wagner M, Besa C, Bou Ayache J, Yasar TK, Bane O, Fung M, Ehman RL, Taouli B. Magnetic Resonance Elastography of the Liver: Qualitative and Quantitative Comparison of Gradient Echo and Spin Echo Echoplanar Imaging Sequences. Investigative radiology 2016 Sep; 51(9).
Lewis S, Vasudevan P, Chatterji M, Besa C, Jajamovich G, Facciuto M, Taouli B. Comparison of gadoxetic acid to gadobenate dimeglumine for assessment of biliary anatomy of potential liver donors. Abdominal radiology (New York) 2016 Jul; 41(7).
Hectors SJ, Wagner M, Besa C, Bane O, Dyvorne HA, Fiel MI, Zhu H, Donovan M, Taouli B. Intravoxel incoherent motion diffusion-weighted imaging of hepatocellular carcinoma: Is there a correlation with flow and perfusion metrics obtained with dynamic contrast-enhanced MRI?. Journal of magnetic resonance imaging : JMRI 2016 Oct; 44(4).
Taouli B, Beer AJ, Chenevert T, Collins D, Lehman C, Matos C, Padhani AR, Rosenkrantz AB, Shukla-Dave A, Sigmund E, Tanenbaum L, Thoeny H, Thomassin-Naggara I, Barbieri S, Corcuera-Solano I, Orton M, Partridge SC, Koh DM. Diffusion-weighted imaging outside the brain: Consensus statement from an ISMRM-sponsored workshop. Journal of magnetic resonance imaging : JMRI 2016 Sep; 44(3).
Bane O, Wagner M, Zhang JL, Dyvorne HA, Orton M, Rusinek H, Taouli B. Assessment of renal function using intravoxel incoherent motion diffusion-weighted imaging and dynamic contrast-enhanced MRI. Journal of magnetic resonance imaging : JMRI 2016 Aug; 44(2).
Kihira S, Kagen AC, Vasudevan P, Jajamovich GH, Schiano TD, Andrle AF, Babb JS, Fischman A, Taouli B. Non-invasive prediction of portal pressures using CT and MRI in chronic liver disease. Abdominal radiology (New York) 2016 Jan; 41(1).
Taouli B, Serfaty L. Magnetic Resonance Imaging/Elastography Is Superior to Transient Elastography for Detection of Liver Fibrosis and Fat in Nonalcoholic Fatty Liver Disease. Gastroenterology 2016 Mar; 150(3).
Dyvorne HA, Jajamovich GH, Bane O, Fiel MI, Chou H, Schiano TD, Dieterich D, Babb JS, Friedman SL, Taouli B. Prospective comparison of magnetic resonance imaging to transient elastography and serum markers for liver fibrosis detection. Liver international : official journal of the International Association for the Study of the Liver 2016 May; 36(5).
Jajamovich GH, Huang W, Besa C, Li X, Afzal A, Dyvorne HA, Taouli B. DCE-MRI of hepatocellular carcinoma: perfusion quantification with Tofts model versus shutter-speed model--initial experience. Magma (New York, N.Y.) 2016 Feb; 29(1).
Yasar TK, Wagner M, Bane O, Besa C, Babb JS, Kannengiesser S, Fung M, Ehman RL, Taouli B. Interplatform reproducibility of liver and spleen stiffness measured with MR elastography. Journal of magnetic resonance imaging : JMRI 2016 May; 43(5).
Bane O, Besa C, Wagner M, Oesingmann N, Zhu H, Fiel MI, Taouli B. Feasibility and reproducibility of BOLD and TOLD measurements in the liver with oxygen and carbogen gas challenge in healthy volunteers and patients with hepatocellular carcinoma. Journal of magnetic resonance imaging : JMRI 2016 Apr; 43(4).
Cui Y, Dyvorne H, Besa C, Cooper N, Taouli B. IVIM Diffusion-weighted Imaging of the Liver at 3.0T: Comparison with 1.5T. European journal of radiology open; 2.
Soyer P, Taouli B, Guiu B, Koh DM, Luciani A, Manfredi R, Vilgrain V, Hoeffel C, Kanematsu M, Vicaut E. Response. Radiology 2015 Jun; 275(3).
Besa C, Bane O, Jajamovich G, Marchione J, Taouli B. 3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function. Magnetic resonance imaging 2015 Nov; 33(9).
Rosenkrantz AB, Padhani AR, Chenevert TL, Koh DM, De Keyzer F, Taouli B, Le Bihan D. Body diffusion kurtosis imaging: Basic principles, applications, and considerations for clinical practice. Journal of magnetic resonance imaging : JMRI 2015 Nov; 42(5).
Mani V, Alie N, Ramachandran S, Robson PM, Besa C, Piazza G, Mercuri M, Grosso M, Taouli B, Goldhaber SZ, Fayad ZA. A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis. Journal of visualized experiments : JoVE 2015 Jun;(100).
Satkunasingham J, Besa C, Bane O, Shah A, de Oliveira A, Gilson WD, Kannengiesser S, Taouli B. Liver fat quantification: Comparison of dual-echo and triple-echo chemical shift MRI to MR spectroscopy. European journal of radiology 2015 Aug; 84(8).
Malyarenko DI, Newitt D, J Wilmes L, Tudorica A, Helmer KG, Arlinghaus LR, Jacobs MA, Jajamovich G, Taouli B, Yankeelov TE, Huang W, Chenevert TL. Demonstration of nonlinearity bias in the measurement of the apparent diffusion coefficient in multicenter trials. Magnetic resonance in medicine 2016 Mar; 75(3).
Besa C, Kakite S, Cooper N, Facciuto M, Taouli B. Comparison of gadoxetic acid and gadopentetate dimeglumine-enhanced MRI for HCC detection: prospective crossover study at 3 T. Acta radiologica open 2015 Feb; 4(2).