Basil G Hanss, PhD
- ASSOCIATE DEAN FOR GRADUATE SCHOOL WELL-BEING AND RESILIENCE | Graduate School of Biomedical Sciences
- ASSOCIATE PROFESSOR | Medicine, Nephrology
- ASSOCIATE PROFESSOR | Medical Education
- ASSOCIATE PROFESSOR | Pharmacological Sciences
Research Topics:Bioinformatics, Biophysics, Cell Biology, Epithelial Cells, Gene Therapy, Intracellular Transport, Kidney, Membrane Proteins/Channels, Membranes, Molecular Biology, Nanotechnology, Protein Complexes, Protein Structure/Function, Proteomics, Structural Biology, Transporters
Dr. Hanss is an Associate Professor at Mt. Sinai School of Medicine with appointments in the Departments of Medicine, Structural and Chemical Biology, and Medical Education. He is also Associate Dean in the Graduate School of Biomedical Sciences. Most recently, Dr. Hanss was appointed as Director of Educational Programs for the Mount Sinai Institute of Technology. He received a Bachelor’s Degree from Lewis and Clark College where he studied Biology, and a Ph.D. in Physiology from Tulane University. He spent a year at the National Institutes of Health as a Postdoctoral Fellow before joining the faculty at Mt. Sinai as a Research Assistant Professor in 1996.
Dr. Hanss’s research focuses on discovering the mechanisms by which nucleic acids cross cell membranes. This poorly understood mechanism is important in nucleic acid signaling systems and in the successful deployment of naked DNA or RNA therapeutic technology. In addition, Dr. Hanss's lab focuses on development of technologies derived from his basic science research. Dr. Hanss is involved in classroom teaching and educational administration as well. He has taught medical and graduate students for more than 25 years at several institutions including Tulane University, the MIT/Harvard M.D./Ph.D. training program, and Mt. Sinai School of Medicine.
Multi-Disciplinary Training AreasBiophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
BS, Lewis and Clark College
PhD, Tulane University
Characterization of a nucleic acid transporter
The precise molecular mechanism(s) responsible for nucleic acid transport across the plasma membrane are being defined. This research has led to the identification and partial characterization of a plasma membrane protein complex that functions as a highly selective nucleic acid-conducting channel. To date the substrate specificity of the channel has been defined and several channel blockers identified. In addition, three putative channel complex proteins have been cloned. Having now obtained definitive evidence for the role of one of these proteins in channel function future projects focus on definition of the role of the other two proteins. Strategies are being applied to develop a molecular model of nucleic acid transport
Hanss BG, Lewy JE, Vari RC. Alterations in glomerular dynamics in congenital, unilateral hydronephrosis. Kidney Int 1994 Jul; 46(1): 48-57.
Rappaport J, Hanss B, Kopp JB, Copeland TD, Bruggeman LA, Coffman TM, Klotman PE. Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy. Kidney Int 1995 May; 47(5): 1462-9.
Leal-Pinto E, Hanss B, Klotman PE. Calcium regulation of a cell surface nucleic acid channel. Kidney Int Suppl 1996 Dec; 57: S4-10.
Lipkowitz MS, Klotman ME, Bruggeman LA, Nicklin P, Hanss B, Rappaport J, Klotman PE. Molecular therapy for renal diseases. Am J Kidney Dis 1996 Oct; 28(4): 475-92.
Hanss B, Stein CA, Klotman PE. Cellular Uptake and Biodistribution of Oligodeoxynucleotides. In: Stein CA, Krieg AM, editors. Applied antisense oligonucleotide technology. New York, Wiley-Liss, Inc.; 1998. pp111-127.
Langer JC, Klotman ME, Hanss B, Tulchin N, Bruggeman LA, Klotman PE, Lipkowitz MS. Adeno-associated virus gene transfer into renal cells: potential for in vivo gene delivery. Exp Nephrol 1998 May-Jun; 6(3): 189-94.
Hanss B, Leal-Pinto E, Bruggeman LA, Copeland TD, Klotman PE. Identification and characterization of a cell membrane nucleic acid channel. Proc Natl Acad Sci USA 1998 Feb 17; 95(4): 1921-6.
Lipkowitz M S, Hanss BG, Tulchin N, Wilson PD, Langer JC, Ross MD, Kurtzman GJ, Klotman PE, Klotman ME. Transduction of renal cells in vitro and in vivo by adeno-associated virus gene therapy vectors. J Am Soc Nephrol 1999 Sep; 10(9): 1908-15.