Beatriz G Pogo, MD
img_Beatriz G Pogo
PROFESSOR EMERITUS | Medicine, Hematology and Medical Oncology
The main research of this laboratory concerns molecular mechanisms of viral pathogenesis.
Fifteen percent of human cancers are associated with or caused by viruses. We are investigating if a virus similar to the mouse mammary tumor virus (MMTV) is involved in human breast cancer pathogenesis. We have found viral sequences similar to MMTV in 38% of the human breast cancers tested. They were expressed as RNA and proteins. A complete proviral structure has been detected with the characteristics of a replicative competent virus.

Recently, we isolated and characterized a beta retrovirus from primary cultures of human breast cancer cells. The retrovirus is able to infect epithelial and lymphocytic human cells. Its potential for malignant transformation is being investigated. Epidemiological studies on breast cancer and retroviral incidence are also carried out by analyzing samples from different geographical locations. The transcriptional profile of breast cancer cells carrying the virus was also investigated. Together, these studies will help to determine if a retrovirus is involved in human breast cancer pathogenesis.

DMSc, Buenos Aires University School of Medicine

MD, Buenos Aires University School of Medicine

Rockefeller University

Sloan Kettering Institute Cancer Center

1997

Member

National Academy of Medicine, Argentina

1989

Fellow

New York Academy of Sciences

1988

Member

Sigma Xi, The Scientific Research Society

1984

Outstanding Women in Science Award

AWIS Metropolitan N.Y.

1964

Damon Runyon Fund Fellowship

Rockefeller University

1959

Research Career Award

National Research Council of Argentina

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Dr. Pogo has not yet completed reporting of Industry relationships.

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