Cameron S McAlpine, PhD
- ASSISTANT PROFESSOR | Medicine, Cardiology
- ASSISTANT PROFESSOR | Neuroscience
Research Topics:Alzheimer's Disease, Atherosclerosis, Brain, Cardiovascular, Hematopoiesis, Immunology, Inflammation, Macrophage, Sleep Medicine
Dr. McAlpine completed his PhD at McMaster University in Canada and his postdoctoral training at the Massachusetts General Hospital and Harvard Medical School. Dr. McAlpine joined the Mount Sinai faculty in 2021 as an Assistant Professor. Dr. McAlpine's research focuses on immune networks and inflammation in sleep, cardiovascular disease, and Alzheimer's disease. Using multidiciplinary approaches he interogates the biological underpinnings linking sleep and the immune system to chronic disease.
The McAlpine lab website can be found here: https://labs.icahn.mssm.edu/mcalpinelab/
Multi-Disciplinary Training AreaNeuroscience [NEU]
BSc, Acadia University
PhD, McMaster University
Postdoctoral Fellowship, Massachusetts General Hospital and Harvard Medical School
CIHR Postdoctoral Award
Banting Postdoctoral Award
K99/R00 NHLBI Pathway to Independence Award
Research in the McAlpine lab
The McAlpine lab investigates immune networks in sleep, cardiovascular disease, and Alzheimer's disease. Please visit the McAlpine lab website: https://labs.icahn.mssm.edu/mcalpinelab/
Project 1. Sleep’s influence on cardiovascular disease
Sleep is critical to health, and we should be asleep for a third of our life. Despite its importance more than a third of adults do not get sufficient sleep. We study how sleep protects against cardiovascular disease and vascular inflammation. We have shown that sleep fragmentation activates hematopoiesis in the bone marrow leading to an oversupply of circulating immune cells which aggravates atherosclerosis (Nature, 2019). We identified a neuro-immune axis linking the brain’s hypothalamus to the control of immune growth factors in the bone marrow. We have also shown that sleep mediates the heterogeneity of hematopoietic stem cells and the emergence of clonal hematopoiesis (Cell, 2021). Moving forward, we are exploring the many complex pathways and systems that link sleep to immune cell biology and cardiovascular health.
Project 2. The role of immune growth factors and sleep in Alzheimer’s disease
The immune system plays an important role in the pathophysiology of Alzheimer’s disease. We pursue research exploring glia cell communication and the role of growth factors in mediating the biology of astrocytes and microglia during Alzheimer’s disease. Secondly, we are interested in the influence of sleep on Alzheimer’s pathology. Sufficient sleep protects against vascular inflammation, therefore does sleep link neurovascular dysfunction to Alzheimer’s disease?