Chris Gennings, PhD
- RESEARCH PROFESSOR | Environmental Medicine & Public Health
- RESEARCH PROFESSOR | Population Health Science and Policy
Dr. Chris Gennings is Director of the Division of Biostatistics and Research Professor in the Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai and holds a secondary appointment as Research Professor in the Department of Population Health Science and Policy. Prior to joining Mount Sinai in 2014, Dr. Gennings held positions at the Virginia Commonwealth University, including as Professor in the Department of Biostatistics and Director for the Research Incubator for the Center for Clinical and Translational Research.
An expert in mixtures statistics, Dr. Gennings has been actively engaged in the field for more than 30 years. Her research interests have focused on design and analysis methodologies for studies of chemical mixtures. This has included methods for both toxicology and epidemiology/clinical studies. Recent work includes development of a body burden index with empirically derived weights linked to health outcomes; development of a holistic measure of wellness using biomarkers of effect; development of a nutrition index; development of weighted quantile sum (WQS) regression – a method that is robust to confounding concerns based on complex correlations among exposure to environmental mixtures; and the development of tests for sufficient similarity, a novel approach that complements current cumulative risk assessment methods and does not require the default assumption of additivity.
At Mount Sinai, Dr. Gennings serves as Deputy Director of the Children’s Health Exposure Analysis Resource (CHEAR) Data Center and as its Director for the Statistical Services and Methods Development Resource, which provides multi-disciplinary expertise in statistics, epidemiology, and bioinformatics for collaboration within the broader children's environmental health research community. Dr. Gennings is also Deputy Director and Director of the Pilot Project Resource of the Mount Sinai Transdisciplinary Center on Early Environmental Exposures, where researchers are studying the health impacts of chemical, genetic, nutritional, and social exposures and the interactions among them.
Dr. Gennings currently serves as Vice-President Elect of the Society of Toxicology’s Mixtures Specialty Session and as a Member of the EPA Board of Scientific Counselors’ Chemical Safety for Sustainability Subcommittee.
BA, University of Richmond
PhD, Virginia Commonwealth University
Kita DH, Meyer KB, Venturelli AC, Adams R, Machado DL, Morais RN, Swan SH, Gennings C, Martino-Andrade AJ. Manipulation of pre and postnatal androgen environments and anogenital distance in rats. Toxicology 2016 Sep;.
Johnstone AF, Strickland JD, Crofton KM, Gennings C, Shafer TJ. Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays. Neurotoxicology 2016 May;.
Christodoulou G, Gennings C, Hupf J, Factor-Litvak P, Murphy J, Goetz RR, Mitsumoto H. Telephone based cognitive-behavioral screening for frontotemporal changes in patients with amyotrophic lateral sclerosis (ALS). Amyotrophic lateral sclerosis & frontotemporal degeneration 2016 Apr;.
Schreier HM, Bosquet Enlow M, Ritz T, Coull BA, Gennings C, Wright RO, Wright RJ. Lifetime Exposure to Traumatic and Other Stressful Life Events and Hair Cortisol in a Multi-Racial/Ethnic Sample of Pregnant Women. Stress (Amsterdam, Netherlands) 2015 Nov;.
Cowell WJ, Bellinger DC, Coull BA, Gennings C, Wright RO, Wright RJ. Associations between Prenatal Exposure to Black Carbon and Memory Domains in Urban Children: Modification by Sex and Prenatal Stress. PloS one 2015 Nov; 10(11).
Brunst KJ, Kannan S, Ni YM, Gennings C, Ganguri HB, Wright RJ. Validation of a Food Frequency Questionnaire for Estimating Micronutrient Intakes in an Urban US Sample of Multi-Ethnic Pregnant Women. Maternal and child health journal 2015 Oct;.
Horton MK, Blount BC, Valentin-Blasini L, Wapner R, Whyatt R, Gennings C, Factor-Litvak P. CO-occurring exposure to perchlorate, nitrate and thiocyanate alters thyroid function in healthy pregnant women. Environmental research 2015 Sep; 143(Pt A).
Bello GA, Dumancas GG, Gennings C. Development and Validation of a Clinical Risk-Assessment Tool Predictive of All-Cause Mortality. Bioinformatics and biology insights 2015 Sep; 9(Suppl 3).
Lioy PJ, Hauser R, Gennings C, Koch HM, Mirkes PE, Schwetz BA, Kortenkamp A. Assessment of phthalates/phthalate alternatives in children's toys and childcare articles: Review of the report including conclusions and recommendation of the Chronic Hazard Advisory Panel of the Consumer Product Safety Commission. Journal of exposure science & environmental epidemiology 2015 Jul-Aug; 25(4).
Schreier HM, Enlow MB, Ritz T, Gennings C, Wright RJ. Childhood abuse is associated with increased hair cortisol levels among urban pregnant women. Journal of epidemiology and community health 2015 Jul;.
Mitsumoto H, Nagy PL, Gennings C, Murphy J, Andrews H, Goetz R, Floeter MK, Hupf J, Singleton J, Barohn RJ, Nations S, Shoesmith C, Kasarskis E, Factor-Litvak P. Phenotypic and molecular analyses of primary lateral sclerosis. Neurology. Genetics 2015 Jun; 1(1).
Czarnota J, Gennings C, Wheeler DC. Assessment of weighted quantile sum regression for modeling chemical mixtures and cancer risk. Cancer informatics 2015 May; 14(Suppl 2): 159-71.
Lioy PJ, Hauser R, Gennings C, Koch HM, Mirkes PE, Schwetz BA, Kortenkamp A. Assessment of phthalates/phthalate alternatives in children's toys and childcare articles: Review of the report including conclusions and recommendation of the Chronic Hazard Advisory Panel of the Consumer Product Safety Commission. Journal of exposure science & environmental epidemiology 2015 May;.
Czarnota J, Wheeler DC, Gennings C. Evaluating geographically weighted regression models for environmental chemical risk analysis. Cancer informatics 2015 May; 14(Suppl 2): 117-27.
Grant LP, Gennings C, Wheeler DC. Selecting spatial scale of covariates in regression models of environmental exposures. Cancer informatics 2015 April; 14(Suppl 2): 81-96.
Lioy PJ, Gennings C, Hauser R, Koch HM, Kortenkamp A. Changing trends in phthalate exposures. Environmental health perspectives 2014 Oct; 122(10).
Sanders AP, Gennings C, Svensson K, Motta V, Mercado-Garcia A, Solano M, Baccarelli AA, Teelez-Rojo MM, Wright RO, Burns HH. Bacterial and Cytokine Mixtures Predict the Length of Gestation and Are Associated With miRNA Expression in the Cervix . Epigenomics 2016 Dec; 9(1): 33-45.
Taylor KW, Joubert BR, Braun JM, Dilworth C, Gennings C, Hauser R, Heindel JJ, Rider CV, Webster TF, Carlin DJ. Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop. Environmental Health Persepectives 2016 Dec; 124(12): 227-229.
Cowell WJ, Bellinger DC, Coull BA, Gennings C, Wright RO, Wright RJ. Associations between Prenatal Exposure to Black Carbon and Memory Domains in Urban Children: Modification by Sex and Prenatal Stress. PLoS One 2015 Nov; 10(11).
Horton MK, Blount BC, Valentin-Blasini L, Wapner R, Whyatt R, Gennings C, Factor-Litvak P. CO-occurring exposure to perchlorate, nitrate and thiocyanate alters thyroid function in healthy pregnant women. Environ. Res. 2015 Nov; 143(ptA): 1-9.
Czarnota J, Gennings C, Colt JS, De Roos AJ, Cerhan JR, Severson RK, Hartge P, Ward MH, Wheeler DC. Analysis of Environmental Chemical Mixtures and Non-Hodgkin Lymphoma Risk in the NCI-SEER NHL Study.. Environmental Health Perspectives 2015 Oct; 123(10): 965-970.
Carrico C, Gennings C, Wheeler DC, Factor-Litvak P. Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting. Journal of Agricultural, Biological, and Environmental Statistics 2015 Mar; 20(1): 100-120.
Gennings C, Carrico C, Factor-Litvak P, Krigbaum N, Cirillo PM, Cohn BA. A cohort study evaluation of maternal PCB exposure related to time to pregnancy in daughters. Environmental Health 2013 Aug; 12(1): 66.
Marshall S, Gennings C, Teuschler LK, Stork LG, Tornero-Velez R, Crofton KM, Rice GE. An empirical approach to sufficient similarity: combining exposure data and mixtures toxicology data. Risk Analysis 2013 Sep; 33(9).
Tate AR, Gennings C, Hoffman RA, Strittmatter AP, Retchin SM. Effects of bone-conducted music on swimming performance. J Strength Cond Res 2012 Apr; 26(4): 982-988.
Gennings C, Ellis R, Ritter JK. Linking empirical estimates of body burden of environmental chemicals and wellness using NHANES data. Environ Int 2012 Feb; 39(1): 56-65.
Yeatts SD, Gennings C, Crofton KM. Optimal design for the precise estimation of an interaction threshold: the impact of exposure to a mixture of 18 polyhalogenated aromatic hydrocarbons. Risk Analysis 2012 Oct; 32(10): 1784-1797.
Gennings C. Statistical Methods in Risk Assessment of Chemical Mixtures. Principles and Practice of Mixtures Toxicology 2012 Dec;: 99 - 124.
Parker SM, Gennings C. Penalized locally optimal experimental designs for nonlinear models. Journal of Agricultural, Biological, and Environmental Statistics 2008 Sep; 13: 334.
Gennings C, Carter WH Jr, Carchman RA, DeVito MJ, Simmons JE, Crofton KM. The impact of exposure to a mixture of eighteen polyhalogenated aromatic hydrocarbons on thyroid function: Estimation of an interaction threshold. Journal of Agricultural, Biological, and Environmental Statistics 2007 Mar; 12(1): 96-111.
Gennings C, Carter WH Jr, Carchman RA, Teuschler LK, Simmons JE, Carney EW. A unifying concept for assessing toxicological interactions: changes in slope. Toxicol Sci 2005 Dec; 88(2): 287-297.
Hamm AK, Carter WH Jr, Gennings C. Analysis of an interaction threshold in a mixture of drugs and/or chemicals. Stat Med 2005 Aug; 24(16): 2493-2507.
Gennings C, Carter WH Jr, Carney EW, Charles GD, Gollapudi BB, Carchman RA. A novel flexible approach for evaluating fixed ratio mixtures of full and partial agonists. Toxicol Sci 2004 Jul; 80(1): 134-150.
Meadows-Shropshire SL, Gennings C, Carter WH Jr, Simmons JE. Analysis of mixtures of drugs/chemicals along a fixed-ratio ray without single-chemical data to support an additivity model. Journal of Agricultural, Biological, and Environmental Statistics 2004 Dec; 9(4): 500-514.
Casey M, Gennings C, Carter WH Jr, Moser VC, Simmons JE. Detecting interaction(s) and assessing the impact of component subsets in a chemical mixture using fixed-ratio mixture ray designs. Journal of Agricultural, Biological, and Environmental Statistics 2004 Sep; 9: 339.
Shih M, Gennings C, Chinchilli VM, Carter WH Jr. Titrating and evaluating multi-drug regimens within subjects.. Statistics in Medicine 2003 Jul; 22(14): 2257-2279.