Constantinos G Hadjipanayis, MD, PhD
- SITE CHAIR, DEPARTMENT OF NEUROSURGERY, MOUNT SINAI BETH ISRAEL
- PROFESSOR | Neurosurgery
- PROFESSOR | Oncological Sciences
Research Topics:Brain, Brain Imaging, Cancer, Nanotechnology
A renowned surgical neuro-oncologist, Constantinos (Costas) G. Hadjipanayis is a Professor and Site Chair of the Department of Neurosurgery at Mount Sinai Downtown Union Square in New York City, New York. He is also Director of Neurosurgical Oncology for the Mount Sinai Health System and Director of the Brain Tumor Nanotechnology Laboratory in the Tisch Cancer Institute.
Both as a neurosurgeon and an NIH-funded scientist, Dr. Hadjipanayis is recognized as a neuro-oncology pioneer for driving advancements in the therapy and surgical management of brain tumors. He is also an internationally recognized expert in minimally invasive, neuro-endoscopic procedures to treat disorders in the brain.
Dr. Hadjipanayis’ interests include surgery and experimental therapeutics for malignant brain tumors, neuro-endoscopy for pituitary tumors and especially colloid cysts, for which his published experience is one of the largest reported. Additionally, he performs microsurgery and radiosurgery for tumors of the skull base and spinal cord.
In addition to his clinical interests, Dr. Hadjipanayis leads multiple cooperative group- and industry-sponsored clinical trials for patients with malignant brain tumors. He was the first in North America to perform approved fluorescence-guided surgery for malignant gliomas with the use of an orphan drug known as Gliolan that can light up tumors in the operating room. He is the lead principal investigator and an IND holder for Gliolan in the USA. He has studied novel targeted therapies for malignant brain tumors such as cancer stem cells delivered by convection-enhanced delivery. He completed a unique animal trial of brain tumors using a magnetic nanoparticle therapeutic agent developed in his laboratory that can target brain tumor cells and can also be seen by MRI.
Dr. Hadjipanayis received his medical degree from Jefferson Medical College in Philadelphia. He completed his internship and residency in neurosurgery at the University of Pittsburgh School of Medicine while simultaneously obtaining his PhD in the Department of Molecular Genetics and Biochemistry. He pursued further advanced training in awake craniotomy techniques and intraoperative cortical/subcortical mapping at the University of California San Francisco (UCSF).
Prior to joining Mount Sinai, Dr. Hadjipanayis was an Associate professor in the Department of Neurosurgery at Emory University School of Medicine, Chief of Neurosurgery at Emory University Hospital Midtown, and Director of the Winship Brain Tumor Center of Emory. He was also the President of the Georgia Neurosurgical Society and the Southeastern Brain Tumor Foundation.
Dr. Hadjipanayis is a member of the American Association of Cancer Research (AACR), American Association of Neurological Surgeons (AANS), Congress of Neurological Surgeons (CNS), AANS/CNS Section on Tumor, and the Society of Neuro-Oncology. He previously served as the President of the non-profit Southeastern Brain Tumor Foundation (SBTF) and the Georgia Neurosurgical Society (GNS).
Dr. Hadjipanayis has been designated a Georgia Cancer Coalition Distinguished Scholar. He has received multiple awards including the American Brain Tumor Association (ABTA) Young Investigator Award, American Academy of Neurological Surgery Award, Atlanta Business Chronicle Health Care Hero Award, Brain Tumor Biotech Young Innovator Award, Southeastern Brain Tumor Foundation Philip Jory Award, and a Robbins Scholar Award from the Winship Cancer Institute of Emory University. He was also the Professor M. Natarajan Memorial Orator at the Madurai Neurosurgical Academy in Chennai, India.
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- Acoustic Neuroma
- Acoustic Neuroma Removal
- Arnold-Chiari Syndrome
- Brain Metastasis
- Brain Tumor And Brain Cancer
- Brain Tumor And Brain Cancer-Adult
- Brain Tumors
- Brain, Spine Tumors
- Cavernous Malformations
- Cerebrospinal Fluid Leak
- Chiari Malformation
- Cushing's Syndrome
- Epidermal Cyst
- Glioblastoma Multiforme
- Hemifacial Spasm
- Intracerebral Hemorrhage (ICH)
- Pituitary Adenoma
- Pituitary Diseases
- Primary Central Nervous System Lymphoma
- Skull Base Tumor/Cancer
- Spinal Cord Tumors
- Spinal Stenosis
- Stereotactic Radiosurgery
- Subdural Hematoma
- Trigeminal Neuralgia
MD, Jefferson Medical College
Internship, General Surgery, University of Pittsburgh Medical Center
Residency, Neurosurgery, University of Pittsburgh Medical Center
Top Doctors - New York Metro Area
Health Care Hero Award Winner
Inaugural Brain Tumor Biotech Young Innovator Award
Emory Clinic Leadership Development
American Brain Tumor Association Young Investigator Award
Translational Research Award
Robbins Scholar Award
Robert Ginsberg Surgical Oncology Award
Philip Jory Award
Annual Academy of Neurological Surgery Award
Georgia Cancer Coalition Distinguished Cancer Clinician and Scientist
Basic Research Fellowship Award
Mentored Clinical Scientist Development Award (K08)
Inaugural Stuart Rowe Society Lectureship Award
Ruth L. Kirschstein National Research Service Award (NRSA) - National Institutes of Health (NIH)
Resident of the Year - Neurological Surgery
Alpha Omega Alpha
Benjamin and Mary Siddons Measey Award
Hobart Amory Hare Medical Student Honor Society
APC National Pathology Honor Society Award
Bernard B. Rotko Scholarship
Nicholas T. Padis Award
First Place Award Recipient - Research Day
Medical Student Scholarship
Golden Key National Honor Society
Phi Beta Kappa
Cordova JS, Gurbani SS, Holder CA, Olson JJ, Schreibmann E, Shi R, Guo Y, Shu HG, Shim H, Hadjipanayis CG. Semi-Automated Volumetric and Morphological Assessment of Glioblastoma Resection with Fluorescence-Guided Surgery. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2015 Oct;.
Kaluzova M, Bouras A, Machaidze R, Hadjipanayis CG. Targeted therapy of glioblastoma stem-like cells and tumor non-stem cells using cetuximab-conjugated iron-oxide nanoparticles. Oncotarget 2015 Apr; 6(11).
Mahmoudi K, Ezrin A, Hadjipanayis C. Small extracellular vesicles as tumor biomarkers for glioblastoma. Molecular aspects of medicine 2015 Nov; 45.
Vigneswaran K, Neill S, Hadjipanayis CG. Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification. Annals of translational medicine 2015 May; 3(7).
Bouras A, Kaluzova M, Hadjipanayis CG. Radiosensitivity enhancement of radioresistant glioblastoma by epidermal growth factor receptor antibody-conjugated iron-oxide nanoparticles. Journal of neuro-oncology 2015 Aug; 124(1).
Hadjipanayis CG, Widhalm G, Stummer W. What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?. Neurosurgery 2015 Nov; 77(5).
Mahmoudi K, Hadjipanayis CG. The application of magnetic nanoparticles for the treatment of brain tumors. Frontiers in chemistry 2014; 2.
Turan N, Halani SH, Baum GR, Neill SG, Hadjipanayis CG. Adult Intramedullary Teratoma of the Spinal Cord: A Case Report and Review of Literature. World neurosurgery 2015 Nov;.