Elena Ezhkova, PhD
- ASSOCIATE PROFESSOR | Cell, Developmental & Regenerative Biology
Research Topics:Cancer, Cellular Differentiation, Developmental Biology, Epigenetics, Epithelial Cells, Stem Cells
For more information, please visit our website:
Multi-Disciplinary Training AreasCancer Biology [CAB], Development, Regeneration, and Stem Cells [DRS]
PhD, Cold Spring Harbor Laboratory
Postdoc, Rockefeller University
The Dr. Harold and Golden Lamport Research Award
Ellison Foundation New Scholar in Aging
Basil O’Connor Starter Award / March of Dimes
NIH K99/R00 Pathway to Independence Award (NIAMS)
New York Stem Cell Foundation Postdoctoral Fellow
Life Sciences Research Foundation Postdoctoral Fellow
Postdoc: Carolina Perdigoto (EMBO Postdoc Fellow), Julian Valdes (Pew Latin American Postdoc Fellow), Idan Cohen
PhD Student: Katherine Dauber (SDBBD T32 training grant), Carmit Bar (Merksammer Scholar)
PostDoc positions are available!
Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nature communications 2018 Jun; 9(1).
Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E. PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification. Cell stem cell 2018 May; 22(5).
Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E. Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS genetics 2016 Jul; 12(7).
Dauber KL, Perdigoto CN, Valdes VJ, Santoriello FJ, Cohen I, Ezhkova E. Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development. The Journal of investigative dermatology 2016 Aug; 136(8).
Wurm S, Zhang J, Guinea-Viniegra J, García F, Muñoz J, Bakiri L, Ezhkova E, Wagner EF. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes & development 2015 Jan; 29(2).
Perdigoto CN, Bardot ES, Valdes VJ, Santoriello FJ, Ezhkova E. Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network. Development 2014 Dec; 141(24).
Bardot ES, Valdes VJ, Zhang J, Perdigoto CN, Nicolis S, Hearn SA, Silva JM, Ezhkova E. Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells. The EMBO journal 2013 Jul; 32(14).
Perdigoto CN, Bardot ES, Ezhkova E. SWItching on epidermal cell fate. Cell stem cell 2013 Feb; 12(2).
Zhang J, Bardot E, Ezhkova E. Epigenetic regulation of skin: focus on the Polycomb complex. Cellular and molecular life sciences : CMLS 2012 Jul; 69(13).
Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes & development 2011 Mar; 25(5).
Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell 2009 Jun; 137(6).
Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 2009 Mar; 136(6).
Lee D, Ezhkova E, Li B, Pattenden SG, Tansey WP, Workman JL. The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators. Cell 2005 Nov; 123(3).
Ezhkova E, Tansey WP. Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. Molecular cell 2004 Feb; 13(3).