Elvin Wagenblast, PhD
- ASSISTANT PROFESSOR | Oncological Sciences
- ASSISTANT PROFESSOR | Pediatrics, Hematology/Oncology
Research Topics:Blood, Cancer Genetics, Leukemia, Stem Cells
Elvin Wagenblast is an Assistant Professor at the Department of Oncological Sciences and the Department of Pediatrics, Division of Pediatric Hematology-Oncology. He is a member of the Black Family Stem Cell Institute, the Tisch Cancer Institute and the Mindich Child Health & Development Institute. Elvin Wagenblast obtained his PhD at Cold Spring Harbor Laboratory in New York with Dr. Greg Hannon. He subsequently completed his postdoctoral studies at Princess Margaret Cancer Center in Toronto with Dr. John Dick. He studies childhood leukemia using CRISPR-based genome editing approaches.
Lab Website: Wagenblast Lab
Multi-Disciplinary Training AreasCancer Biology [CAB], Development Regeneration and Stem Cells [DRS], Neuroscience [NEU]
BSc, Heidelberg University, Germany
PhD, Cold Spring Harbor Laboratory, NY
Postdoctoral, Princess Margaret Cancer Center, Canada
American Society of Hematology Scholar Award
Leukemia and Lymphoma Society Special Fellow
Alex’s Lemonade Stand Foundation Young Investigator
Human Frontier Science Program Fellowship
Boehringer Ingelheim Fonds Fellowship
Leveraging Genome Editing to Study Childhood Leukemia
The central question of his lab is to understand how a normal blood stem cell can become cancerous. In leukemia, the initiating genetic mutations occur as early as during fetal development. His team applies cutting-edge CRISPR/Cas9 genome editing approaches in human primary blood stem cells to model the pre-leukemic and leukemic phases of acute myeloid and acute lymphoblastic leukemia in vivo. The goal is to uncover insights into the genetic, cellular and developmental mechanisms of leukemia, with a particular focus on childhood leukemia, and identify therapeutic vulnerabilities of the disease.
Wagenblast E, Araújo J, Gan OI, Cutting SK, Murison A, Krivdova G, Azkanaz M, McLeod JL, Smith SA, Gratton BA, Marhon SA, Gabra M, Medeiros JJ, Manteghi S, Chen J, Chan-Seng-Yue M, Garcia-Prat L, Salmena L, De Carvalho DD, Abelson S, Abdelhaleem M, Chong K, Roifman M, Shannon P, Wang JC, Hitzler JK, Chitayat D, Dick JE, Lechman ER. Mapping the cellular origin and early evolution of leukemia in Down syndrome. Science (New York, N.Y.) 2021 07; 373(6551).
Wagenblast E, Azkanaz M, Smith SA, Shakib L, McLeod JL, Krivdova G, Araújo J, Shultz LD, Gan OI, Dick JE, Lechman ER. Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells. Nature communications 2019 10; 10(1).
Knott SR, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, Turgeon MO, Fish L, Erard N, Gable AL, Maceli AR, Dickopf S, Papachristou EK, D'Santos CS, Carey LA, Wilkinson JE, Harrell JC, Perou CM, Goodarzi H, Poulogiannis G, Hannon GJ. Asparagine bioavailability governs metastasis in a model of breast cancer. Nature 2018 02; 554(7692).
Wagenblast E, Soto M, Gutiérrez-Ángel S, Hartl CA, Gable AL, Maceli AR, Erard N, Williams AM, Kim SY, Dickopf S, Harrell JC, Smith AD, Perou CM, Wilkinson JE, Hannon GJ, Knott SR. A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis. Nature 2015 Apr; 520(7547).