Emily Bernstein, PhD
- PROFESSOR | Oncological Sciences
- PROFESSOR | Dermatology
Research Topics:Cancer, Chromatin, Epigenetics, Gene Regulation, Molecular Biology, Stem Cells
Emily Bernstein, PhD, Professor of Oncological Sciences and Dermatology, is Co-leader of the Cancer Mechanisms Research Program at The Tisch Cancer Institute. As such, Dr. Bernstein facilitates basic research on genetic, epigenetic, biochemical, and developmental pathways that drive cancer initiation and progression, and fosters intra- and inter-program collaborations that accelerate the development of novel, targeted therapies for cancer.
Dr. Bernstein studies epigenetic regulation of gene expression in cancer and development, with the long-term goal of understanding the chromatin changes that take place at the molecular level during the transformation process of normal cells to cancer cells. Her team studies melanoma, breast cancer, and neuroblastoma.
Dr. Bernstein regularly teaches courses on cancer biology and serves on numerous PhD thesis committees at the Icahn School of Medicine at Mount Sinai. She is permanent member of the Cancer Genetics Study Section of the NIH Center for Scientific Review and serves as a reviewer for additional grant foundations.
Multi-Disciplinary Training AreasCancer Biology [CAB], Development, Regeneration, and Stem Cells [DRS]
PhD, SUNY Stony Brook/Cold Spring Harbor Laboratory
The Rockefeller University
Melanoma Research Alliance Established Investigator Award
Pershing Square Sohn Prize for Young Investigators in Cancer Research
Irma T. Hirschl Charitable Trust Research Award
Young Cancer Scientist Research Award
Innovative Research Grant Finalist
Tisch Cancer Institute Developmental Fund Award
New Scholar Award
Research Scholar Award
National Science Foundation Postdoctoral Fellowship
The Dr. Harold and Golden Lamport Research Award
Summary of Current Research
Our focus is on epigenetic regulation of gene expression in multiple biological pathways including cancer (melanoma, breast cancer, neuroblastoma), cellular senescence and stem cell biology. We have a strong research focus on histone variants and their dedicated chaperones, chromatin remodelers, and histone modifying enzymes, which are all frequently altered in cancer.
Chromatin is the complex of DNA and its intimately associated proteins - with histones constituting the major component. This template is an attractive candidate for shaping the features of a cell's epigenetic landscape. Disruption of a cell's epigenetic balance can perturb chromatin structure and gene regulation, contributing to disease states. There is a growing interest both in academia and industry to target the machinery that regulate chromatin dynamics, and this burgeoning field is of great interest to our laboratory.
Our laboratory collaborates with numerous investigators at ISMMS and other institutes to translate our basic mechanistic findings towards pre-clinical or clinical trials. We work closely with medicinal chemists, immunologists, and external partners towards this goal.