Eric A Sobie, PhD
- PROFESSOR | Pharmacological Sciences
Research Topics:Biophysics, Cardiovascular, Computational Biology, Electrophysiology, Mathematical Modeling of Biomedical Systems, Membrane Proteins/Channels, Signal Transduction
The Sobie Laboratory
Multi-Disciplinary Training AreasCancer Biology [CAB], Pharmacology and Therapeutics Discovery [PTD]
BSE, Duke University
PhD, The Johns Hopkins University School of Medicine
Postdoctoral Fellowship, University of Maryland
Dr. Harold and Golden Lamport Research Award
Specific Research Interest:
Mechanisms underlying cardiac dysfunction and arrhythmias using physiological experiments coupled with mathematical modeling
Postdoctoral Fellows: Young-Seon Lee, Eva Polakova
Graduate and Medical Students: John Jones Molina, Megan Cummins, Ryan Devenyi, Pavan Dalal
Undergraduates and Visitors: Kathleen McGovern, Alessandro Giovannini, Allie Lopatkin
Research Personnel: Frank Fabris
The Sobie Laboratory combines mathematical modeling with state-of-the-art experimental techniques in order to improve our quantitative understanding of cardiac physiology. We generate predictions using mathematical models, then test these predictions experimentally by measuring calcium and transmembrane voltage in heart cells. This provides novel insight into the initiation of arrhythmias and dysfunction that occurs in disease states such as heart failure. Specific research projects are described in more detail at our lab website.
Keywords: Biophysics, Calcium, Computer Simulation, Electrophysiology, Heart, Mathematical and Computational Biology, Systems Biology
Current Research Studies:
2010-2013: Novel computational approaches for understanding drug-induced arrhythmia. American Heart Association 10GRNT4170020. The goal of this project is to use new computational methods to understand sources of inter-patient variability in arrhythmias caused by pharmacological agents.
2005-2014: Sarcoplasmic reticulum calcium leak and calcium instability in cardiac myocytes; National Institutes of Health R01 HL 076230; The goal of this project is to investigate, through experiments and simulation, sources of unstable, potentially arrhythmogenic calcium release in cardiac myocytes.
2007-2012: Systems Biology Center in New York. National Institutes of Health P50 GM071558-01; Dr. Sobie leads one of the projects in this multi-investigator grant. We are developing methods for explicit multi-scale simulations of heart function.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Sobie during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Other Activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership.
- Invivo Sciences
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.