Eric A Sobie, PhD
- SENIOR ASSOCIATE DEAN FOR PROGRAMMATIC DEVELOPMENT
- PROFESSOR | Pharmacological Sciences
Research Topics:Biophysics, Cardiovascular, Computational Biology, Electrophysiology, Mathematical Modeling of Biomedical Systems, Membrane Proteins/Channels, Signal Transduction
Multi-Disciplinary Training AreaPharmacology and Therapeutics Discovery [PTD]
BSE, Duke University
PhD, The Johns Hopkins University School of Medicine
Postdoctoral Fellowship, University of Maryland
Dr. Harold and Golden Lamport Research Award
Specific Research Interest:
Mechanisms underlying cardiac dysfunction and arrhythmias using physiological experiments coupled with mathematical modeling
Postdoctoral Fellows: Young-Seon Lee, Eva Polakova
Graduate and Medical Students: John Jones Molina, Megan Cummins, Ryan Devenyi, Pavan Dalal
Undergraduates and Visitors: Kathleen McGovern, Alessandro Giovannini, Allie Lopatkin
Research Personnel: Frank Fabris
The Sobie Laboratory combines mathematical modeling with state-of-the-art experimental techniques in order to improve our quantitative understanding of cardiac physiology. We generate predictions using mathematical models, then test these predictions experimentally by measuring calcium and transmembrane voltage in heart cells. This provides novel insight into the initiation of arrhythmias and dysfunction that occurs in disease states such as heart failure. Specific research projects are described in more detail at our lab website.
Keywords: Biophysics, Calcium, Computer Simulation, Electrophysiology, Heart, Mathematical and Computational Biology, Systems Biology
Current Research Studies:
2010-2013: Novel computational approaches for understanding drug-induced arrhythmia. American Heart Association 10GRNT4170020. The goal of this project is to use new computational methods to understand sources of inter-patient variability in arrhythmias caused by pharmacological agents.
2005-2014: Sarcoplasmic reticulum calcium leak and calcium instability in cardiac myocytes; National Institutes of Health R01 HL 076230; The goal of this project is to investigate, through experiments and simulation, sources of unstable, potentially arrhythmogenic calcium release in cardiac myocytes.
2007-2012: Systems Biology Center in New York. National Institutes of Health P50 GM071558-01; Dr. Sobie leads one of the projects in this multi-investigator grant. We are developing methods for explicit multi-scale simulations of heart function.
Sarkar AX, Christini DJ, Sobie EA. Exploiting mathematical models to illuminate electrophysiological variability between individuals. J Physiol 2012;.
Liu OZ, Lederer WJ, Sobie EA. Does the Goldilocks Principle apply to calcium release restitution in heart cells?. J Mol Cell Cardiol 2012; 52: 3-6.
Sobie EA, Lederer WJ. Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles. J Mol Cell Cardiol 2012; 52.
Bao L, Kefaloyianni E, Lader J, Hong M, Morley G, Fishman GI, Sobie EA, Coetzee WA. Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system. Circulation. Arrhythmia and Electrophysiology 2011; 4.
Williams GS, Chikando AC, Tuan HT, Sobie EA, Lederer WJ, Jafri MS. Dynamics of calcium sparks and calcium leak in the heart. Biophys J 2011; 101.
Sarkar AX, Sobie EA. Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm 2011 Nov; 8(11).
Ramay HR, Liu OZ, Sobie EA. Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity. Cardiovasc Res 2011; 91.
Sobie EA, Lee YS, Jenkins SL, Iyengar R. Systems biology--biomedical modeling. Science Signaling 2011; 4.
Lee YS, Dun W, Boyden PA, Sobie EA. Complex and rate-dependent beat-to-beat variations in Ca²⁺ transients of canine Purkinje cells. J Mol Cell Cardiol 2011; 50.
Chung CY, Bien H, Sobie EA, Dasari V, McKinnon D, Rosati B, Entcheva E. Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization. FASEB Journal 2011; 25.
Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. J Mol Cell Cardiol 2011; 51.
MacQuaide N, Ramay HR, Sobie EA, Smith GL. Differential sensitivity of Ca²⁺ wave and Ca²⁺ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. J Physiol 2010; 588.