Eric J Nestler, MD, PhD
- DEAN FOR ACADEMIC AND SCIENTIFIC AFFAIRS
- DIRECTOR FRIEDMAN BRAIN INSTITUTE
- PROFESSOR | Neuroscience
- PROFESSOR | Pharmacological Sciences
- PROFESSOR | Psychiatry
Research Topics:Addiction, Behavioral Health, Depression, Epigenetics, Molecular Biology, Neuroscience, Stress, Synapses, Synaptic Plasticity, Synaptogenesis
Dr. Nestler is the Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs at the Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models.
Visit Eric Nestler's Laboratory of Molecular Psychiatry, Conte Center on Depression and NIDA Program Project Grant for more information.
Psychiatry, American Board of Psychiatry and Neurology
Multi-Disciplinary Training AreasDevelopment Regeneration and Stem Cells [DRS], Neuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]
MD, Yale University School of Medicine
PhD, Yale University
Internship, Medicine/Psychiatry, Mclean Hospital
Residency, Clinical Psychiatry, Yale University School of Medicine
Fellowship, Pharmacology, Yale University School of Medicine
Fellowship, Clinical Psychiatry, Yale University School of Medicine
Redelsheimer Distinguished Research Award, Society of Biological Psychiatry
Wilbur Cross Distinguished Alumnus Medal, Yale University
Paul Hoch Distinguished Service Award
Sarnat Prize, Institute of Medicine
American Academy of Arts and Science
Institute of Medicine (National Academy of Medicine)
Nestler Lab, Laboratory of Molecular Psychiatry
Specific Clinical/Research Interest: Molecular neurobiology of drug addiction and depression; transcriptional and epigenetic regulation in the brain.
Our research focuses on identifying the neurobiological basis of drug addiction and depression in rodent models. We study the molecular and cellular changes that occur in regions of the brain important for reward and motivation in response to chronic administration of a drug of abuse or chronic exposure to stress. We are particularly interested in long-lasting changes that are mediated via alterations in gene expression and chromatin remodeling. The result of the research will guide future efforts toward the development of more effective treatments for addiction and depression.
For a complete list of publications, please visit Selected Publications.
For more, please visit the Nestler Lab.