Eric J Nestler, MD, PhD
- DEAN FOR ACADEMIC AND SCIENTIFIC AFFAIRS
- DIRECTOR FRIEDMAN BRAIN INSTITUTE
- PROFESSOR | Neuroscience
- PROFESSOR | Pharmacological Sciences
- PROFESSOR | Psychiatry
Research Topics:Addiction, Behavioral Health, Depression, Epigenetics, Molecular Biology, Neuroscience, Stress, Synapses, Synaptic Plasticity, Synaptogenesis
Dr. Nestler is the Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs at the Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models.
Visit Eric Nestler's Laboratory of Molecular Psychiatry, Conte Center on Depression and NIDA Program Project Grant for more information.
Multi-Disciplinary Training AreasDisease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
MD, Yale University School of Medicine
PhD, Yale University
Internship, Psychiatry, McLean Hospital
Residency, Psychiatry, Yale University School of Medicine
Fellowship, Clinical Pharmacology, Yale University School of Medicine
Fellowship, Psychiatry, Yale University School of Medicine
Redelsheimer Distinguished Research Award, Society of Biological Psychiatry
Wilbur Cross Distinguished Alumnus Medal, Yale University
Paul Hoch Distinguished Service Award
Sarnat Prize, Institute of Medicine
American Academy of Arts and Science
Institute of Medicine (National Academy of Medicine)
Nestler Lab, Laboratory of Molecular Psychiatry
Specific Clinical/Research Interest: Molecular neurobiology of drug addiction and depression; transcriptional and epigenetic regulation in the brain.
Our research focuses on identifying the neurobiological basis of drug addiction and depression in rodent models. We study the molecular and cellular changes that occur in regions of the brain important for reward and motivation in response to chronic administration of a drug of abuse or chronic exposure to stress. We are particularly interested in long-lasting changes that are mediated via alterations in gene expression and chromatin remodeling. The result of the research will guide future efforts toward the development of more effective treatments for addiction and depression.
For a complete list of publications, please visit Selected Publications.
For more, please visit the Nestler Lab.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Nestler during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
- PsychoGenics, Inc.
- Biohaven Pharmaceuticals; PSYLO; PsychoGenics, Inc.; Society of Biological Psychiatry
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Berg Pharma (Berg Biosystems); PsychoGenics, Inc.
Scientific Advisory Board:
- Berg Pharma (Berg Biosystems)
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