Ernesto Guccione, PhD
- SENIOR FACULTY | Oncological Sciences
- SENIOR FACULTY | Pharmacological Sciences
Research Topics:Cancer, Developmental Biology, Epigenetics, Post-Transcriptional Processing
During my PhD at the International Center for Genetic Engineering Biotechnology (ICGEB) I have studied the oncogenic functions of HPV E6/E7 viral proteins and the relevance of splicing in regulating E6 functions.
During my postdoctoral work at the European Institute of Oncology I studied the role of chromatin in defining c-MYC target site recognition. I have also identified PRMT6, a member of the Protein Arginine MethylTransferase (PRMT) family, as an important enzyme regulating transcriptional repression.
I am currently an Associate Professor in the department of Oncological Sciences at Icahn School of Medicine at Mount Sinai and a Snr.PI and Coordinator of the Program in Epigenetics and Diseases at IMCB in Singapore.
MS, University of Bologna
PhD, International School for Advanced Studies (SISSA)/International Center for Genetic Engineering Biotechnology (ICGEB)
Post Doc, European Institute of Oncology
Post-Transcriptional Processing, Epigenetics, Developmental Biology, Cancer
The Guccione lab has a long-standing interest in understanding basic mechanisms of transcriptional and post-transcriptional regulation in order to identify therapeutic opportunities in oncology. Currently, we are interested in the function in development and disease of Protein MethylTrasnferases (PMTs) and in modulation of Alternative Splicing using Antisense Oligonucleotide (AON)-based approaches. We use biochemistry, mouse models and next generation sequencing techniques to understand the molecular mechanisms of action of candidate PMTs or specific isoforms. The range of techniques and approaches used in the lab has allowed us to characterize the mechanism of action of specific PMTs (e.g. PRMT5 and PRMT6) or oncogenic isoforms (e.g. MDM4l/s), which are now of great interest for their clinical applications.