George W Huntley, PhD
- PROFESSOR | Neuroscience
Research Topics:Anatomy, Autism, Axon Guidance, Brain, Cell Adhesion, Cerebral Cortex, Developmental Neurobiology, Electrophysiology, Extracellular Matrix, Memory, Neurophysiology, Neuroscience, Neurotransmitters, Regeneration, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience
- Synaptic plasticity and remodeling in health and disease
- Development of cortical connectivity
- Synaptic cell adhesion molecules
Dr. Huntley's laboratory uses multidisciplinary approaches to investigate mechanisms through which strength and organization of synaptic connection are modified during development and throughout adulthood by experience or by genetic mutations that lead to autism or Parkinson's disease.
Multi-Disciplinary Training AreaNeuroscience [NEU]
PhD, University of California
Specific Clinical/Research Interests: Development and Plasticity of Synaptic Circuit Structure and Function
* Mouse models of autism and Parkinson's disease
* Synaptic plasticity
* Development of cortical connectivity
* Synaptic cell adhesion molecules
Dr. Huntley's laboratory uses multidisciplinary approaches to investigate mechanisms through which strength and organization of synaptic connection are modified during development or adulthood by experience or by genetic mutations that lead to autism or Parkinson's disease.
Synapse structure and function is continuously modified during development and throughout life by experience, such as learning new skills or forming new memories. Such synaptic plasticity is thus critical for normal brain function. Synapse development and plasticity can also become derailed by genetic mutations that lead to autism or other neurological or psychiatric diseases, including familial forms of Parkinson's disease. Dr. Huntley's research uses principally mouse models to focuse on mechanisms of synaptic plasticity through which synaptic structure and function are modified by experience or genetic mutation.
Research projects include:
1) the role of synaptic adhesion proteins in synapse and circuit development and plasticity;
2) molecules and mechanisms regulating corticostriatal circuit development and plasticity in autism and Parkinson's disease models.
Visit Dr. George Huntley's Laboratory of Synaptic Circuit Development and Plasticity for more information.
Matikainen-Ankney BA, Kezunovic N, Menard C, Flanigan ME, Zhong Y, Russo SJ, Benson DL, Huntley GW. Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood. The Journal of Neuroscience 2018 Nov; 38(45).
Matikainen-Ankney BA, Kezunovic N, Mesias RE, Tian Y, Williams FM, Huntley GW, Benson DL. Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation. The Journal of Neuroscience 2016 07; 36(27).
Friedman L, Benson D, Huntley GW. Cadherin-based trans-synaptic networks in establishing and modifying neural connectivity. Current Topics Dev Biol 2015; 112: 415-465.
Friedman LG, Riemslagh FW, Sullivan JM, Mesias R, Williams FM, Huntley GW, Benson DL. Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits. The Journal of Comparative Neurology 2015 Jan; 523(1).
Nikitczuk JS, Patil SB, Matikainen-Ankney BA, Scarpa J, Shapiro ML, Benson DL, Huntley GW. N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo. Hippocampus 2014; 24: 943-962.
Bozdagi O, Wang X, Nikitczuk JS, Anderson TR, Bloss EG, Radice GL, Zhou Q, Benson DL, Huntley GW. Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. Journal of Neuroscience 2010; 39: 9984-9989.
Huntley GW, Elste AM, Patil SB, Bozdagi O, Benson DL, Steward O. Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo. Hippocampus 2012 Jan; 22(1).
Aujla PK, Huntley GW. Early postnatal expression and localization of matrix metalloproteinases-2 and -9 during establishment of rat hippocampal synaptic circuitry. Journal of Comparative Neurology 2014; 522: 1249-1263.
Bozdagi O, Nagy V, Kwei KT, Huntley GW. In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity. Journal of Neurophysiology 2007; 98: 334-344.
Wang XB, Bozdagi O, Nikitczuk JS, Zhai ZW, Zhou Q, Huntley GW. Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately. Proc Natl Acad Sci USA 2008; 105: 19519-19524.
Kichula EA, Huntley GW. Developmental and comparative aspects of posterior medial thalamocortical innervation of barrel cortex in mice and rats. Journal of Comparative Neurology 2007; 509: 239-258.