Guo-Cheng Yuan, PhD
- PROFESSOR | Genetics and Genomic Sciences
Research Topics:
Bioinformatics, Brain, Cancer, Chromatin, Computational Biology, Epigenomics, Gene Regulation, Genomics, Immunology, Systems BiologyDr. Guo-Cheng Yuan is a Professor of Computational Biology at Icahn School of Medicine at Mount Sinai. He is also a faculty member of the Icahn Genomics Institute. Prior to his current appointment, he was an Associate Professor at Dana-Farber Cancer Institute/Harvard Medical School and a Principal Faculty member at Harvard Stem Cell Institute. He obtained B.S and M.A degrees in Mathematics from Peking University, and a PhD degree in Mathematics from University of Maryland, followed by postdoctoral training at Brown University. Dr. Yuan transitioned into a computational biologist by taking up a postdoctoral fellow position at Harvard University before joining Dana-Farber as a faculty member. Dr. Yuan’s group has developed a number of computational methods for analyzing and interpreting large-scale biological data. Notable examples include methods for epigenomics (Haystack, diHMM, CUT&RUNTools), for single-cell analysis (SCUBA, GiniClust, Giotto), and for genome-editing (CRISPResso). For over a decade, Dr. Yuan’s group has collaborated with basic scientists and cancer biologists to elucidate the gene regulatory mechanisms in development and diseases.
Multi-Disciplinary Training Areas
Artificial Intelligence and Emerging Technologies in Medicine [AIET], Genetics and Genomic Sciences [GGS]Education
PhD, University of Maryland
Postdoc, Harvard University
Single-Cell Analysis
We develop computational methods to analyze and integrate single-cell multi-omic data with the aim to systematically characterize the landscape of cellular states and investigate the underlying regulatory mechanisms.
Epigenetic regulation
We develop computational methods to analyze various genome-wide assays to characterize the structural organization and regulatory role of chromatin in development and diseases.
Spatial Transcriptomics
We develop computational methods to comprehensively analyze spatial data and user-friendly, generally applicable software packages and apply these tools to dissect tissue structure and investigate the role of environment in mediating cellular activities.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Yuan did not report having any of the following types of financial relationships with industry during 2021 and/or 2022: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.