Guo-Cheng Yuan

Guo-Cheng Yuan, PhD

  • PROFESSOR | Genetics and Genomic Sciences

Research Topics:

Bioinformatics, Brain, Cancer, Chromatin, Computational Biology, Epigenomics, Gene Regulation, Genomics, Immunology, Systems Biology

Dr. Guo-Cheng Yuan is a Professor of Computational Biology at Icahn School of Medicine at Mount Sinai. He is also a faculty member of the Icahn Genomics Institute. Prior to his current appointment, he was an Associate Professor at Dana-Farber Cancer Institute/Harvard Medical School and a Principal Faculty member at Harvard Stem Cell Institute. He obtained B.S and M.A degrees in Mathematics from Peking University, and a PhD degree in Mathematics from University of Maryland, followed by postdoctoral training at Brown University. Dr. Yuan transitioned into a computational biologist by taking up a postdoctoral fellow position at Harvard University before joining Dana-Farber as a faculty member. Dr. Yuan’s group has developed a number of computational methods for analyzing and interpreting large-scale biological data. Notable examples include methods for epigenomics (Haystack, diHMM, CUT&RUNTools), for single-cell analysis (SCUBA, GiniClust, Giotto), and for genome-editing (CRISPResso).  For over a decade, Dr. Yuan’s group has collaborated with basic scientists and cancer biologists to elucidate the gene regulatory mechanisms in development and diseases.

Multi-Disciplinary Training Areas

Artificial Intelligence and Emerging Technologies in Medicine [AIET], Genetics and Genomic Sciences [GGS]


PhD, University of Maryland

Postdoc, Harvard University