Helen S Mayberg - Neurology | Mount Sinai

Biography

Specialties

Neurology, Psychiatry, Neurosurgery

Research Topics

Depression, Imaging, Neurology, Neuromodulation, Neuroscience, Psychiatry

Multi-Disciplinary Training Area

Artificial Intelligence and Emerging Technologies in Medicine [AIET], Neuroscience [NEU]

Research

Deep Brain Stimulation

Pioneering research which has been heralded as one of the first hypothesis-driven treatment strategies for a major mental illness.

Clinical Trial:
Electrophysiological Biomarkers to Optimize Deep Brain Stimulation for Depression

The Icahn School of Medicine at Mount Sinai is running a single-center experimental trial of deep brain stimulation (DBS) to the subcallosal cingulate region (Area 25) for treatment resistant depression (TRD). The goal of this study is to refine and optimize this treatment approach using a newly available neuromodulation system (the Medtronic Summit RC+S) that allows brain activity during ongoing therapeutic DBS to be recorded from the brain in real-time. This study will further define brain readouts that track depression recovery, providing novel strategies to monitor and guide treatment and device programming decisions in patients receiving DBS for TRD.

Participating Mount Sinai Programs:

To enroll in the study contact Emma Meyer at 212-241-6539 or dac@mssm.edu.
For more information visit Mount Sinai Clinical Trials.

GRANTS

UH3NS103550
Electrophysiological biomarkers to Optimize DBS for Depression
Using a newly available bi-directional neuromodulation system that allows live streaming of oscillatory activity at the site of stimulation,
this study will define novel control strategies to guide programming for DBS delivery.

Hope for Depression Research Foundation
Multimodal Assessment of Deep Brain Stimulation Effects in Treatment Resistant Depression Phase IV
Continued studies of psychophysiological changes during acute and chronic DBS.

NSF 1822606/1822553
CRCNS Collaborative Research: Modeling and Manipulating Dynamic Network Activity in the Brain
This study using Connectome-based Dynamic Network Modeling (CDNM) to examine how interactions between brain macroscale structure and the dynamics of local neural populations leads to the emergence of complex functional networks and the rich repertoire of brain states. The developed CDNMs will be evaluated on abnormal connectomes obtained from patients MDD and subsequently tested in patients undergoing DBS treatment.
Shella Keilholz (PI, Emory)

Education

MD, University of Southern California

Internship, Internal Medicine, LAC-USC Medical Center

Residency, Neurology, Columbia University Neurological Surgery

Certifications

American Board of Psychiatry and Neurology

Honors & Awards

2020

3nd Annual Frances and Kenneth Eisenberg Research Prize, University of Michigan

University of Michigan

2019

39th TS Srinivasan Endowment Orator, Chennai, India

2018

Johns Hopkins University Society of Scholars, elected

Johns Hopkins University

2018

Steven E. Hyman Award for Distinguished Service to the Field of Neuroethics, International Neuroethics Society

International Neuroethics Society

2017

American Academy of Arts and Sciences, elected member

American Academy of Arts and Sciences

2016

V. Sagar Sethi Mental Health Research Award

Psychiatric Foundation of North Carolina

2016

National Academy of Inventors, elected member

National Academy of Inventors

2015

Distinguished Service Award, American Psychiatric Association

American Psychiatric Association

2015

Robert Wartenberg Award and Lecturer, American Academy of Neurology

American Academy of Neurology

2015

Paul MacLean Award, American Psychosomatic Society

American Psychosomatic Society

2014

Cura Personalis Award, Georgetown University Medical Center

Georgetown University Medical Center

2014

Gold Medal Award, Society of Biological Psychiatry

Society of Biological Psychiatry

2014

American Association for the Advancement of Science, AAAS, elected fellow

American Association for the Advancement of Science, AAAS

2013

Joan and Stanford Alexander Annual Award in Psychiatry, Houston, Texas

2013

25th Annual Pasarow Foundation Award, Neuropsychiatry

Pasarow Foundation

2010

Senior Award for Translational Neuroscience, Roche-Nature Medicine

Roche-Nature Medicine

2009

The Raymond Adams Lecturer & Award, American Neurological Association

American Neurological Association, Baltimore

2009

Frontiers in Clinical Neuroscience, Speaker and Award, American Academy of Neurology

Academy of Neurology

2009

Dorothy C. Fuqua Chair of Psychiatric Neuroimaging and Therapeutics, Emory University

Emory University

2008

National Academy of Medicine, elected member

Institute of Medicine

2008

Centenary Lecturer, University of Toronto

University of Toronto, Dept of Psychiatry

2007

Falcone Prize in Mood Disorders Research, NARSAD

NARSAD

2003

Arnold Pfeffer Prize, Society of Neuropsychoanalysis

Society of Neuropsychoanalysis

2003

American College of Neuropsychopharmacology, Elected Member

American College of Neuropsychopharmacology

2002

Distinguished Investigator Award, NARSAD

NARSAD

2000

American Neurological Association, Elected Member

American Neurological Association

1999

Litchfield Lecturer, Oxford College UK

Oxford College, England

1999

Sandra Rotman Chair in Neuropsychiatry, University of Toronto

University of Toronto

1996

Gerald Klerman Memorial Award runner-up, NARSAD

NARSAD

Publications

335

Publications

Selected Publications

Cortical signatures of sleep are altered following effective deep brain stimulation for depression. Joram J. van Rheede, Sankaraleengam Alagapan, Timothy J. Denison, Patricio Riva-Posse, Christopher J. Rozell, Helen S. Mayberg, Allison C. Waters, Andrew Sharott. Translational Psychiatry

The utility of measuring daily hassles and uplifts in understanding outcomes to treatments for major depressive disorder. Benjamin W. Furman, W. Edward Craighead, Helen S. Mayberg, Tanja Mletzko, Charles B. Nemeroff, Boadie W. Dunlop. Psychiatry Research

Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation. Andreas Seas, M. Sohail Noor, Ki Sueng Choi, Ashan Veerakumar, Mosadoluwa Obatusin, Jacob Dahill-Fuchel, Vineet Tiruvadi, Elisa Xu, Patricio Riva-Posse, Christopher J. Rozell, Helen S. Mayberg, Cameron C. McIntyre, Allison C. Waters, Bryan Howell. Proceedings of the National Academy of Sciences of the United States of America

View All Publications

Video

FBI Cyber Series - Implications for Next Generation Strategies to Optimize Therapeutic DBS

Examining depression through the lens of the brain | Dr. Helen Mayberg | TEDxEmory

NeuroTechX Webinar#9: New treatments for Depression. Presented by Dr. Helen Mayberg

Office Locations

Mount Sinai West Floor 10 Room 10G-47

1000 10th Ave

New York, NY 10019

212-523-8276

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Mayberg during 2023 and/or 2024. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

Abbott Laboratories
Cogwear
Blackrock Neuro
Nextsense

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Mayberg during 2023 and/or 2024. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

Abbott Laboratories
Cogwear
Blackrock Neuro
Nextsense

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.