Hideki Ueno

Hideki Ueno, MD, PhD

  • PROFESSOR | Microbiology

Research Topics:

Autoimmunity, B Cells, Cellular Differentiation, Cellular Immunity, Cytokines, Dendritic Cells, Immunology, Infectious Disease, Inflammation, Influenza Virus, Lymphocytes, Molecular Biology, Neuroscience, T Cells

Hideki Ueno, M.D, Ph.D. is a Professor at Global Health and Emerging Pathogens Institute and Department of Microbiology. Dr. Ueno’s laboratory studies the molecular and cellular mechanisms controlling the adaptive immune system in humans. The major research topic in the past decade has been the biology of T follicular helper (TFH) cells, a CD4+ T cell subset fundamental for the generation of antibody responses. His laboratory has identified functionally distinct subsets within blood circulating TFH cells in humans, and demonstrated that alterations in the composition of the subsets are associated with human autoimmune diseases. This seminal work has been cited more than 500 times. This work has led to their identification of a unique TFH subset in charge of antibody responses following seasonal influenza vaccination. Dr. Ueno’s laboratory also identified multiple key factors and pathways promoting the differentiation of human TFH cells. Many of these factors are dominant or unique to the human system, highlighting the important differences between humans and animal models in antibody responses. His laboratory currently works on the analysis of the adaptive immune system in autoimmune diseases, neuroinflammatory diseases, and post-vaccinations, in addition to the basic science of human TFH cells.

 

Multi-Disciplinary Training Areas

Immunology [IMM], Microbiology [MIC]

Education

MD, Kyoto University

PhD, Graduate School of Medicine, Kyoto University

Post-doctoral fellow, Baylor Institute for Immunology Research