Hugh A Sampson, MD
- PROFESSOR | Pediatrics, Allergy and Immunology
Specialties:Pediatrics, Pediatric Allergy and Immunology
Research Topics:Allergy, B Cells, Immunological Tolerance, T Cells
Dr. Hugh Sampson is the Kurt Hirschhorn Professor of Pediatrics at the Icahn School of Medicine at Mount Sinai and Director Emeritus of the Jaffe Food Allergy Institute. Dr. Sampson's research interests have focused on food allergic disorders, and now include work on the pathogenesis of food-induced anaphylaxis, characterization of allergenic food proteins and their processing by the immune system, genetics of food allergy, development of novel diagnostic tests, and mechanisms of immunotherapeutic strategies for treating food allergies including basic studies and clinical trials in oral, sublingual and epicutaneous immunotherapy and the potential use of biologics, such as anti-IgE and anti-cytokine monoclonal antibodies. His research is funded by a number of grants from the National Institutes of Health, including the recently funded Exposure to Vaginal Microbiome in C-section Infants at High-risk for Allergies – A Pilot Study. Dr. Sampson supervises one clinic/week in pediatric allergy and is involved in teaching fellows and residents. He is an Associate Editor of Pediatric Allergy & Immunology, past-president of the American Academy of Allergy, Asthma & Immunology, and a member of the National Academy of Medicine.
In the News
Dr. Sampson talks about food allergies in The Daily News featureThe Daily Check Up.
Dr. Sampson discusses childhood food allergies in The Daily News feature The Daily Check Up.
American Board of Allergy & Immunology
American Board of Pediatrics
Multi-Disciplinary Training AreaImmunology [IMM]
MD, S.U.N.Y., Buffalo
Residency, Pediatrics, Children's Memorial Hospital
Fellowship, Allergy & Immunology, Duke University Hospital
Brett Ratner Award
Outstanding Research in Food Hypersensitivity Disorders
International Award in Nutrition
New York Top Doctors
Allergic Disease Academic Award
Specific Clinical/Research Interest: Immunopathogenic mechanisms of food allergic disorders and asthma; immunomodulatory therapies
Postdoctoral Fellows: Jacob Kattan, MD
Research Personnel: Alexander Grishin, PhD; Madhan Masilamani, PhD, Jing S Lin, PhD, Luda Bardina, MS; Galina Grishin, MS; Gustavo Gimenez, BS, Mohanapriya Kamalakannan, BS
Summary of Research Studies:
Our laboratory is evaluating immunopathologic mechanisms of food allergic disorders. Specifically we are identifying allergenic proteins at a molecular and structural level, and investigating the interaction between IgE antibodies and allergenic proteins and the immune response at a cellular and molecular level. Studies utilize patient specimens and murine models in an attempt to elucidate underlying mechanisms. Allergenic proteins in egg, milk, peanut, several tree nuts, shrimp and some fish have been fully characterized and full-length cDNAs isolated and cloned. A number of therapeutic strategies are under investigation utilizing murine models of anaphylaxis and asthma including the use of recombinant proteins, DNA vaccines, and CpG-conjugated proteins. Several early stage, human clincial trials are in progress to treat food allergic disorders including oral and sublingual immunotherapy, herbal therapies, and engineered recombinant protein vaccines.
In addition, our laboratory is serving as the mechanistic center for the NIAID Inner City Asthma Consortium and the Consortiium for Food Allergy Research. The asthma consortium is investigating the role of allergic sensitization in inner city children and its potential role in the increased morbidity and mortality found in this population. The overall goal is to determine whether the nature and quantity of environmental allergens within the inner city, especially cockroach, are unique in their ability to determine and drive the intensity of allergic inflammation in sensitized children residing in the inner city and thus the severity of their asthma.
The food allergy consortium is investigating the immunologic mechanisms associated with the devleopment of peanut allergy and the development of tolerance ["outgrowing"] to egg and milk allergy, the immunologic consequences of oral immunotherapy for egg allergy, and the immunologic consequences of sublingual immunotherapy for peanut allergy. The lab employs a variety of techniques to identify and purify proteins including SDS-PAGE, immunoblotting and HPLC. Recombinant proteins are generated from cDNA isolated from appropriate cDNA libraries. A variety of techniques are utilized to study both humoral and cellular responses of patient groups and controls. Characterization of cellular responses includes intracytoplasmic staining, mRNAgeneration, and characterization of cytokines secreted into cell supernatants. Similar studies are conducted in the murine models.
Jaffe Food Allergy Institute