Ivan E de Araujo, PhD
- PROFESSOR | Neuroscience
Research Topics:Aerodigestive Tract, Allergy, Electrophysiology, Gastroenterology, Mathematical and Computational Biology, Motor Control, Motor Neuron, Neuromodulation, Neurophysiology, Parkinson's Disease, Vocal Tract
Majored in Philosophy at the University of Brasilia, followed by postgraduate work in Artificial Intelligence at the University of Edinburgh. Obtained his Doctorate (DPhil) in Medical Physiology and Imaging at the University of Oxford, under the supervision of Edmund T. Rolls. Performed postdoctoral work in Neurobiology at Duke University Medical Center, where he recorded in awake animals the activity of networks of neurons linked to the digestive tract. From 2007 through 2018, he directed his Neurobiology of Feeding Laboratory at Pierce Labs (Yale University), previous to joining Mount Sinai in August 2018. After describing the taste-independent calorie sensing phenomenon, his main interests revolve around the question of how the body communicates with the central nervous system, and in establishing interfaces for brain stimulation therapies triggered by peripehral signals.
Multi-Disciplinary Training AreasArtificial Intelligence and Emerging Technologies in Medicine [AIET], Neuroscience [NEU]
BA, University of Brasilia
MA, University of Brasilia
MSc, University of Edinburgh
DPhil, University of Oxford
The Young Investigator in Gustation of 2008
Our lab focuses on understanding how the brain senses and controls the body that is attached to it. We specifically aim at anatomically and physiologically describing the neural networks that link the brain to craniofacial and abdominal organs. My laboratory employs a range of techniques suitable to study the interaction between the central and peripheral nervous systems. Those include special surgical approaches, cell-specific neuroanatomical tracing, pathway-defined optogenetics, and in vivo electrophysiological recordings from nerves, muscles, and neurons.
Closed-Loop Systems for Motor Control
We are also developing closed-loop algorithms and interfaces to control peripheral musculatures, with emphasis on networks controlling the craniofacial system. We are researching the deterioration of these systems in Parkinson's disease and ways to ameliorate symptoms via stimulation techniques.
Han W, Tellez LA, Perkins MH, Perez IO, Qu T, Ferreira J, Ferreira TL, Quinn D, Liu ZW, Gao XB, Kaelberer MM, Bohórquez DV, Shammah-Lagnado SJ, de Lartigue G, de Araujo IE. A Neural Circuit for Gut-Induced Reward. Cell 2018 10; 175(3).
Han W, Tellez LA, Rangel MJ, Motta SC, Zhang X, Perez IO, Canteras NS, Shammah-Lagnado SJ, van den Pol AN, de Araujo IE. Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala. Cell 2017 Jan; 168(1-2).
Han W, Tellez LA, Niu J, Medina S, Ferreira TL, Zhang X, Su J, Tong J, Schwartz GJ, van den Pol A, de Araujo IE. Striatal Dopamine Links Gastrointestinal Rerouting to Altered Sweet Appetite. Cell metabolism 2016 Jan; 23(1).
Tellez LA, Han W, Zhang X, Ferreira TL, Perez IO, Shammah-Lagnado SJ, van den Pol AN, de Araujo IE. Separate circuitries encode the hedonic and nutritional values of sugar. Nature neuroscience 2016 Mar; 19(3).