James M Gallo, PharmD, PhD
- ADJUNCT PROFESSOR | Pharmacological Sciences
I'm a pharmacokineticist focused on the experimental therapeutics of anticancer drugs. In particular we use systems-based pharmacokinetic [PK] and pharmacodynamic [PD] – systems pharmacology - approaches to advance drug development and improve drug therapy of brain tumors. We hope to identify new chemotherapeutic strategies and enhance the translational foundation of preclinical to clinical research.
Gallo Laboratory website
Multi-Disciplinary Training AreaPharmacology and Therapeutics Discovery [PTD]
BS, Massachusetts College of Pharmacy
PharmD, University of Florida
PhD, University of Arizona
Systems Pharmacology of Brain Tumors
Our lab is focused on pharmacokinetic [PK]- and pharmacodynamic [PD]-directed brain tumor chemotherapy. We have incorporated systems-based methods with PK/PD methods to derive cell-type specific PK/PD and enhanced PD models that link PK and PD information at the cell and molecular scale. Ongoing projects concern anticancer drug discovery and development, oncometabolites, epigenetic modulators and tumor heterogeneity. The projects utilize a diverse array of methods that allow us to build mechanistic PK/PD models of anticancer drugs that they are scalable from preclinical models to patients. The ultimate objective of our work is to discover new targets and drugs and means to optimize multi-drug chemotherapeutic regimens.
For more information, please visit the Gallo laboratory website.