Jerry Chipuk, PhD
- ASSOCIATE PROFESSOR | Oncological Sciences
- ASSOCIATE PROFESSOR | Dermatology
Research Topics:Anti-Tumor Therapy, Apoptosis/Cell Death, Cancer, Cell Biology, Cell Transformation, Drug Resistance, Imaging, Lipid Signaling, Membrane Proteins/Channels, Membranes, Mitochondria, Molecular Biology, Oncogenes, Protein Kinases, Signal Transduction, Tumor Suppressor Genes, Tumorigenesis
Jerry Edward Chipuk, PhD, is Associate Professor of Oncological Sciences and Dermatology, Associate Director of Basic Science Shared Resources at The Tisch Cancer Institute, and Director for Cell Biology in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. He joined Mount Sinai in 2010, following post-doctoral fellowships at St. Jude Children’s Research Hospital in Memphis and La Jolla Institute for Allergy and Immunology in San Diego.
Dr. Chipuk studies fundamental mitochondrial biology within the perspective of human disease etiology and treatment. His laboratory has developed multiple model systems, collaborations, and experimental tools to investigate the intersections between mitochondria, cell biology, and disease.
As Associate Director of Basic Science Shared Resources, Dr. Chipuk supports Mouse Genetics and Gene Targeting, Flow Cytometry, Microscopy, and Human Immune Monitoring Center resources within the cancer community, and he develops new core resources for The Tisch Cancer Institute. Dr. Chipuk is a member of both The Tisch Cancer Institute and the Diabetes, Obesity, & Metabolism Institute.
Dr. Chipuk is an associate editor for numerous journals focused on molecular and cellular biology. He also serves on the Board of Directors of the International Cell Death Society and is a Senior Affiliate with bioR𝛘iv, a preprint server for biology operated by the Cold Spring Harbor Laboratory.
Multi-Disciplinary Training AreasCancer Biology [CAB], Genetics and Data Science [GDS]
BS, Baldwin-Wallace College
PhD, Case Western Reserve University
Postdoctoral Training, La Jolla Institute for Allergy and Immunology
Postdoctoral Training, St. Jude Children’s Research Hospital
Career Development Award
Research Scholar Grant
Dr. Harold and Golden Lamport Research Award
Basil O'Connor Phase-In Award
Young Scientist Cancer Research Fund
Basil O'Connor Award
Ruth Kirschstein NRSA
Our current research interests are divided into three areas, but adopt a unified theme to decipher the interplay between mitochondria and cell death signaling:
I. What are the biochemical, physiological, and structural consequences of protein·protein interactions within the BCL-2 family?
II. How does the mitochondrial environment influence BCL-2 family function and the core cell death machinery?
III. How do oncogenic and tumor suppressor signals intersect with the mitochondrial dynamics machinery to regulate tumorigenesis and chemosensitivity?
We explore the above questions using state-of-the-art apoptosis, metabolism, and cancer biology model systems --- usually focusing on hematological malignancies and melanoma.
Visit the Chipuk Laboratory