Jerry Chipuk, PhD
- PROFESSOR | Oncological Sciences
- PROFESSOR | Dermatology
Research Topics:Anti-Tumor Therapy, Apoptosis/Cell Death, Cancer, Cell Biology, Cell Transformation, Drug Resistance, Imaging, Lipid Signaling, Membrane Proteins/Channels, Membranes, Mitochondria, Molecular Biology, Oncogenes, Protein Kinases, Signal Transduction, Tumor Suppressor Genes, Tumorigenesis
Jerry Edward Chipuk, PhD, is Professor of Oncological Sciences and Dermatology, Associate Director of Basic Science Shared Resources at The Tisch Cancer Institute, and Director for Cell Biology in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. He joined Mount Sinai in 2010, following post-doctoral fellowships at St. Jude Children’s Research Hospital in Memphis and La Jolla Institute for Allergy and Immunology in San Diego.
Dr. Chipuk studies fundamental mitochondrial biology within the perspective of human disease etiology and treatment. His laboratory has developed multiple model systems, collaborations, and experimental tools to investigate the intersections between mitochondria, cell biology, and disease.
As Associate Director of Basic Science Shared Resources, Dr. Chipuk supports Mouse Genetics and Gene Targeting, Flow Cytometry, Microscopy, and Human Immune Monitoring Center resources within the cancer community, and he develops new core resources for The Tisch Cancer Institute. Dr. Chipuk is a member of both The Tisch Cancer Institute and the Diabetes, Obesity, & Metabolism Institute.
Dr. Chipuk is an associate editor for numerous journals focused on molecular and cellular biology. He also serves on the Board of Directors of the International Cell Death Society and is a Senior Affiliate with bioR𝛘iv, a preprint server for biology operated by the Cold Spring Harbor Laboratory.
Multi-Disciplinary Training AreaCancer Biology [CAB]
BS, Baldwin-Wallace College
PhD, Case Western Reserve University
Postdoctoral Training, La Jolla Institute for Allergy and Immunology
Postdoctoral Training, St. Jude Children’s Research Hospital
Career Development Award
Research Scholar Grant
Dr. Harold and Golden Lamport Research Award
Basil O'Connor Phase-In Award
Young Scientist Cancer Research Fund
Basil O'Connor Award
Ruth Kirschstein NRSA
Our current research interests are divided into three areas, but adopt a unified theme to decipher the interplay between mitochondria and cell death signaling:
I. What are the biochemical, physiological, and structural consequences of protein·protein interactions within the BCL-2 family?
II. How does the mitochondrial environment influence BCL-2 family function and the core cell death machinery?
III. How do oncogenic and tumor suppressor signals intersect with the mitochondrial dynamics machinery to regulate tumorigenesis and chemosensitivity?
We explore the above questions using state-of-the-art apoptosis, metabolism, and cancer biology model systems --- usually focusing on hematological malignancies and melanoma.
Visit the Chipuk Laboratory
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Chipuk did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.